Protection of cattle against bovine leukemia virus (BLV) infection could be attained by DNA vaccination

• Authors: Anna Brillowska , Sławomir Dąbrowski , Jan Rułka , Piotr Kubiś , Ewa Buzała , Józef Kur
• Languages of publication: EN

Abstracts

EN

The bovine leukemia virus (BLV) envelope gene encoding extracellular glycoprotein gp51 and transmembrane glycoprotein gp30 was cloned into a vehicle expression vector under the human cytomegalovirus (CMV) intermediate early promoter. The intramuscular injection of this plasmid vector generated a cellular immune response. Seven out of ten cows vaccinated with the DNA construct resisted a drastic challenge (500 BLV-infected lymphocytes as an infectious dose).

Keywords

EN

DNA vaccine; env gene; expression plasmid; immunization

• Journal: Acta Biochimica Polonica
• Year: 1999
• Volume: 46
• Issue: 4
• Pages: 971-976

Dates

published

1999

received

1999-01-12

revised

1999-07-26

accepted

1999-10-20

Contributors

author

Anna Brillowska

• Technical University of Gdańsk, Department of Microbiology, ul. G. Narutowicza 11/12, 80-952 Gdańsk, Poland

author

Sławomir Dąbrowski

• Technical University of Gdańsk, Department of Microbiology, ul. G. Narutowicza 11/12, 80-952 Gdańsk, Poland

author

Jan Rułka

• National Veterinary Research Institute, Laboratory of Cell Pathology, 24-100 Puławy, Poland

author

Piotr Kubiś

• National Veterinary Research Institute, Laboratory of Cell Pathology, 24-100 Puławy, Poland

author

Ewa Buzała

• National Veterinary Research Institute, Laboratory of Cell Pathology, 24-100 Puławy, Poland

author

Józef Kur

• Technical University of Gdańsk, Department of Microbiology, ul. G. Narutowicza 11/12, 80-952 Gdańsk, Poland