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1999 | 46 | 4 | 961-966
Article title

Inhibitory effect of resveratrol on free radical generation in blood platelets

Content
Title variants
Languages of publication
EN
Abstracts
EN
Resveratrol (3,4',5-trihydroxystilbene), a compound found in many plants, has been shown to prevent coronary heart diseases and to exert a variety of antiinflammatory and anticancerogenic effects. It is effective in lowering the level of serum lipids and in inhibiting platelet aggregation. We evaluated the effect of trans-resveratrol on the production of free radicals in pig blood platelets and showed that resveratrol inhibited the production of different reactive oxygen species (O^·_2H^2O^2, singlet oxygen and organic radicals) measured by the luminol-dependent chemiluminescence in resting platelets (P < 0.05). Resveratrol inhibited also the generation of radicals in platelets activated by thrombin (P < 0.05). Treatment of platelets with resveratrol at concentrations of 6.25 and 12.5 μg/ml caused a statistically insignificant increase in the production of O^·-_2 in these cells, as measured by reduction of cytochrome c; however, at higher doses (25, 50 and 100 μg/ml) resveratrol distinctly reduced the generation of O^·-_2 in platelets (P < 0.05). We suggest that free radicals play an important role in the reduced reactivity of blood platelets induced by resveratrol.
Year
Volume
46
Issue
4
Pages
961-966
Physical description
Dates
published
1999
received
1999-05-26
revised
1999-07-13
accepted
1999-11-23
Contributors
author
  • Department of General Biochemistry, Institute of Biochemistry, University of Łódź, St. Banacha 12/16, 90-237 Łódź, Poland
  • Department of General Biochemistry, Institute of Biochemistry, University of Łódź, St. Banacha 12/16, 90-237 Łódź, Poland
  • Department of General Biochemistry, Institute of Biochemistry, University of Łódź, St. Banacha 12/16, 90-237 Łódź, Poland
  • Department of General Biochemistry, Institute of Biochemistry, University of Łódź, St. Banacha 12/16, 90-237 Łódź, Poland
  • Department of Preventive Medicine, Military School of Medicine, Łódź, Poland
  • Department of General Biochemistry, Institute of Biochemistry, University of Łódź, St. Banacha 12/16, 90-237 Łódź, Poland
References
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv46i4p961kz
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