Accumulation of collagen in ovarian benign tumours

• Authors: Małgorzata Wolańska , Krzysztof Sobolewski , Edward Bańkowski , Marek Drożdżewicz
• Languages of publication: EN

Abstracts

EN

Extracellular matrix components of benign ovarian tumours (cystadenoma, adenofibroma, cystadenofibroma) were analysed. The investigated tumours contained twice as much collagen than control ovarian tissues. Significant alterations in mutual quantitative relationships between collagens of various types were observed. The proportion of type I collagen decreased and that of type III collagen increased. The accumulation of collagen was accompanied by a reduction in sulphated glycosaminoglycan content whereas the amount of hyaluronic acid was not changed. Dermatan sulphate was the most abundant glycosaminoglycan component. It is suggested that the accumulation of collagen (natural barrier to the migration of tumour cells) and underexpression of glycosaminoglycans/proteoglycans (binding some growth factors and interleukins) may exert an inhibitory effect on tumour growth.

Keywords

EN

ovarian tumours; collagen; glycosaminoglycan; elastin

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 1999
• Volume: 46
• Issue: 4
• Pages: 941-947

Dates

published

1999

received

1999-09-09

Contributors

author

Małgorzata Wolańska

• Department of Biochemistry, Medical Academy of Białystok, A. Mickiewicza 2, 15-230 Białystok 8, Poland

author

Krzysztof Sobolewski

• Department of Biochemistry, Medical Academy of Białystok, A. Mickiewicza 2, 15-230 Białystok 8, Poland

author

Edward Bańkowski

author

Marek Drożdżewicz

• Department of Gynaecology, Medical Academy of Białystok, A. Mickiewicza 2, 15-230 Białystok 8, Poland