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2012 | 33 | 4 | 529-538
Article title

Encapsulation of Chondrocytes in Hydrogel Systems Effect of Chitosan Viscosity and Microcapsule Shape

Content
Title variants
Languages of publication
EN
Abstracts
EN
Alginate - chitosan - alginate multilayer hydrogel encapsulation systems were investigated for encapsulation of chondrocytes. Hydrogel is crosslinked due to ionic interaction between cationic chitosan and anionic alginate, and additionally by calcium ions. Two types of chitosan with molecular weight were investigated. Cells were encapsulated in two shape microcapsules, microbeads with diameter size 300 - 400 and 500 - 600 μm and fibres with diameter 500 - 600 μm. The work provides a detailed examination of the impact of the microencapsulation process on the growth of cells. The viability of chondrocytes can be influenced by the size of produced microcapsules, while the shape of microcapsules has no important significance on cell viability. The applied encapsulation methods do not contain harmful stages and create conducive conditions for cell growth. A possible application area of the developed system is dressing and regeneration of damaged joint cartilage.
Publisher

Year
Volume
33
Issue
4
Pages
529-538
Physical description
Dates
published
1 - 12 - 2012
online
28 - 12 - 2012
Contributors
author
  • Warsaw University of Technology, Faculty of Chemical and Process Engineering, Waryńskiego 1, 00-645 Warszawa, Poland, i.wasiak@ichip.pw.edu.pl
author
  • Warsaw University of Technology, Faculty of Chemical and Process Engineering, Waryńskiego 1, 00-645 Warszawa, Poland
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.-psjd-doi-10_2478_v10176-012-0043-9
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