Full-text resources of PSJD and other databases are now available in the new Library of Science.
Visit https://bibliotekanauki.pl


Preferences help
enabled [disable] Abstract
Number of results
2011 | 3 | 30-34

Article title

Associations between circulating adiponectin and selected plasma biochemical variables in physically active young men and women


Title variants

Languages of publication



Study aim: To evaluate the relationships between circulating adiponectin and FFA, and other biochemical variables (glycerol, glucose and insulin) in young, healthy non-obese men and women.Material and methods: A group of 53 male and 54 female students participated in the study. The following compounds were determined in plasma: free fatty acids (FFA), glucose and glycerol (colorimetrically), and insulin and adiponectin (by immunoassay). Insulin resistance index (HOMA-IR) was calculated from fasting insulin and glucose concentrations.Results: Mean plasma glucose was slightly lower (p<0.01), and plasma insulin and HOMA-IR markedly higher (p<0.01 - 0.001) in female than in male subjects. Percent body fat was positively correlated with plasma FFA in both groups (p<0.01), but with plasma glycerol (p<0.001) in female students only. Plasma adiponectin was negatively correlated with percent body fat (p<0.02), plasma glycerol (p<0.001) and FFA (p<0.05) in female subjects only.Conclusions: Gender-related differences in body fat may affect the relationship between adiponectin and indices of lipid metabolism.







Physical description


1 - 1 - 2011
17 - 3 - 2011


  • Department of Biochemistry, University of Physical Education, Warsaw, Poland
  • Department of Biochemistry, University of Physical Education, Warsaw, Poland


  • Basu R., Ch.D. Man, M. Campioni, A. Basu, G. Klee, G. Toffolo, C. Cobelli, R. A. Rozza (2006) Effect of age and sex on postprandial glucose metabolism. Differences in glucose turnover, insulin secretion, insulin action, and hepatic insulin extraction. Diabetes 55:2001-2014.[Crossref]
  • Bernstein E. L., P. Koutkia, K. Ljungquist, J. Breu, B. Canavan, S. Greenspoon (2004) Acute regulation of adiponectin by free fatty acids. Metabolism 53:790-793.[PubMed][Crossref]
  • Boschmann M., M. Rosenbaum, R. L. Leibel, K. R. Segal (2002) Metabolic and hemodynamic responses to exercise in subcutaneous adipose tissue and skeletal muscle. Int.J. Sports Med. 23:537-543.[PubMed][Crossref]
  • Bortz W. M., P. Paul, A. C. Haff, W. LHolmes (1972) Glycerol turnover and oxidation in man. J. Clin. Invest. 51:1537-1546.[Crossref]
  • Bouchard C., J-P. Desprès, P. Mauriège (2005) Genetic and nongenetic determinants of regional fat distribution. Endocr. Rev. 14:72-93.
  • Böttner A., J. Kratzsch, G. Müller, T. M. Kapellen, S. Blüher, E. Keller, S. Blüher, E. Keller, M. Blüher, W. Kiess (2004) Gender differences of adiponectin levels develop during the progression of puberty and are related to serum androgen levels. J. Clin. Endocrinol. Metab. 89:4053-4061.[Crossref]
  • Bruun J. M., A. S. Lihn, C. Verdich, S. B. Pedersen, S. Tourbo, A. Astrup, B. Richelsen (2003) Regulation of adiponectin by adipose tissue-derived cytokines: in vivo and in vitro investigations in humans. Am. J. Physiol. Endocrinol. Metab. 285:E527-E533.
  • Ceddia R. B., R. Somwar, A. Maida, X. Fang, G. Bikopoulos, G. Sweeney (2005) Globular adiponectin increases GLUT4 translocation and glucose uptake but reduces glycogen synthesis in rat skeletal muscle cells. Diabetologia 48:132-139.
  • Cong L., K. Chen, J. Li, P. Gao, Q. Li. S. Mi, X. Wu, A. Z. Zhao (2007) Regulation of adiponectin and leptin secretion and expression by insulin through a PI3K-PDE3B dependent mechanism in rat primary adipocytes. Biochem. J. 403:519-525.
  • Côté M., P. Mauriège, J. Bergeron, N. Almèras, A. Tremblay, I. Lemieux, J-P. Desprès (2005) Adiponectinemia in visceral obesity: impact on glucose tolerance and plasma lipoprotein and lipid levels in men. J. Clin. Endocrinol. Metab. 90:1434-1439.[Crossref]
  • Davis S. N., P. Galassetti, D. H. Wasserman, D. Tate (2000) Effects of gender on neuroendocrine and metabolic responses to exercise in normal men. J. Clin. Endocrinol. Metab. 85: 224-230.
  • Delporte M-L., T. Funahashi, M. Takahashi, Y. Matsuzawa, S. M. Brichard (2002) Pre-and post-translational negative effect of β-adrenoceptor agonist on adiponectin secretion: in vitro and in vivo studies. Biochem. J. 367:677-685.
  • Delporte M-L., S. A. El Mkadem, M. Quisquater, S. M. Brichard (2004) Leptin treatment increased plasma adiponectin but barely decreased plasma resisitin of ob/ob mice. Am. J. Physiol. Endocrinol. Metab. 287:E446-E453.
  • Diamond M. P., T. Jones, S. Caprio, L. Hallarman, M. C. Diamond, M. Addabbo, W. V. Tamborlane, R. S. Sherwin (1993) Gender influences counterregulatory hormone responses to hypoglycaemia. Metabolism 42:1568-1572.[PubMed][Crossref]
  • Dullaart R. P. F., S. C. Riemens, J. R. Meinardi, B. H. R. Wolffenbuttel, W. J. Sluiter (2005) Plasma adiponectin is modestly decreased during 24-hour insulin infusion but not after inhibition of lipolysis by Acipimox. Scand. J. Clin. Lab.Invest. 65:523-532.
  • Esbjörnsson-Lijedahl M., C. J. Sundberg, B. Norman, E. Jansson (1999) Metabolic response in type I and type II muscle fibers during a 30-s cycle sprint in men and women. J. Appl. Physiol. 87:1326-1332.
  • Esbjörnsson-Lijedahl M, K. Bodin, E. Jansson (2002) Smaller muscle ATP reduction in women than in men by repeated bouts of sprint exercise. J. Appl. Physiol. 93:1075-1083.
  • Hallikainen M., M. Kolehmainen, U. Schwab, D. E. Laaksonen, L. Niskanen, R. Rauramaa, J. Pihlajamäki, M. Uusitupa, T. A. Miettinen, H. Gylling (2007) Serum adipokines are associated with cholesterol metabolism in the metabolic syndrome. Clin. Chim. A. 383:126-132.[WoS]
  • Gustavsson C., K. Yassin, E. Wahlström, L. Cheung, J. Lindberg, K. Brismar, C-G.Őstenson, G. Norstedt, P. Tollet-Egnell (2010) Sex-different hepatoglycogen content and glucose output in rats. BMC Biochemistry 11:38. (http://www.biochemistrycentralcom/[Crossref][WoS]
  • Hauner H. (2005) Secretory factors for human adipose tissue and their functional role. Proc. Nutr. Soc. 64:163-169.[PubMed][Crossref]
  • Kazumi T., A. Kawaguchi, T. Hirano, G. Yoshino (2004) Serum adiponectin is associated with high-density lipoprotein cholesterol, triglycerides, and low-density lipoprotein particle size in young healthy men. Metabolism 53: 589-593.[PubMed][Crossref]
  • Kley S., M. Hoening, J. Glushka, E. S. Jin, S. C. Burges, M. Waldron, E. T. Jordan, J. H. Prestegard, D. C. Ferguson, Sh. Wu, D. E. Olson (2009) The impact of obesity, sex, and diet on hepatic glucose production in cats. Am. J. Physiol. Endocrinol. Metab. 296:R936-R943.
  • Kowalska I., M. Straczkowski, A. Nikołajuk, A. Adamska, M. Karczewska-Kupczewska, E. Odziomek, I. Kinalska, M. Górska (2008) Insulin resistance, serum adiponectin, and proinflammatory markers in young subjects with the metabolic syndrome. Metabolism 57:1539-1544.[PubMed][Crossref]
  • Krzyżanowska K., F. Mittermayer, W. Krugluger, M. Roden, G. Scherthaner, M. Woltz (2007) Adiponectin concentrations increase during acute FFA elevation in humans treated with rosiglitazone. Horm. Metab. Res. 39:769-772.[WoS][Crossref][PubMed]
  • Lavoie F., F. Frisch, P. Brassard, F. Normand-Lauzière, D. Cyr, R. Gagnon, R. Drouin, J-P. Baillargeon, A. C. Carpentier (2009) Relationship between total and high molecular weight adiponectin levels and plasma nonestrified fatty acid tolerance during enhanced intravascular triacylglycerol lipolysis in men. J. Clin. Endocrinol. Metab. 94:998-1004.[Crossref][WoS]
  • Marliss E. B., S. H. Kreisman, A. Manzon, J. B. Halter, M. Vranic, Sh. J. Nessim (2000) Gender differences in glucoregulatory responses to intense exercise. J. Appl. Physiol. 88:457-466.
  • Martin B., M. Pearson, L. Kebejian, E. Golden, A. Keselman, M. Bender, O. Carlson, J. Egan, B. Ladenheim, J-L. Cadet, K. G. Becker, W. Wood, K. Duffy P. Vinayakumar, S. Maudsley, M. P. Mattson (2007) Sex-dependent metabolic, neuroendocrine, and cognitive responses to dietary energy restriction and excess. Endocrinology 148: 4318-4333.[PubMed][WoS][Crossref]
  • Martin L. J., J. G. Woo, S. R. Daniels, E. Goodman, L. M. Dolan (2005) The relationship of adiponectin with insulin and lipids are strengthen with increasing adiposity. J. Clin. Endocrinol. Metab. 90: 4255-4259.[Crossref]
  • Matthews D. R., J. P. Hosker, A. S. Rudenski, B. A. Naylor, D. F. Treacher, R. C. Turner (1985) Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28: 412-419.[PubMed][Crossref]
  • Mittendorfer B., J. F. Horowitz, S. Klein (2002) Effect of gender on lipid kinetics during endurance exercise of moderate intensity in untrained subjects. Am. J. Physiol. Endocrinol. Metab. 283:E58-E65.
  • Nakashima Y., K. Inukai, K. Imai, Y. Ikegami, T. Awata, Sh. Katayama (2008) Involvement of low adiponectin levels in impaired glucose tolerance. Metabolism 57:1350-1354.[Crossref][PubMed]
  • Nogueira A. Ch., L. L. Souza, A. Cabanelas, K. J. Oliveira, C. Cabanelas Pazos-Moura (2007) Effect of experimental hypoand hyperthyroidism on serum adiponectin. Metabolism 56:6-11.[WoS]
  • Piechaczek H. (1975) Piechaczek H. Estimation of total body fat by the densitometric and anthropometric methods. Stud. Phys. Anthropol. 2:33-46.
  • Roepstorff C., C. H. Steffensen, M. Madsen, B. Stallknecht, I. L. Kanstrup, E. A. Richter, B. Kiens (2002) Gender differences in substrate utilization during submaximal exercise in endurance-trained subjects. Am. J. Physiol. 282: E435-E447.
  • Schneider J. G., M.von Enyatten, S. Schiekofer, P. P. Nawroth, K. A. Dugi (2005) Low plasma adiponectin levels are associated with increased hepatic lipase activity in vivo. Diabetes Care 28:2181-2186.[Crossref]
  • Shimada K., T. Miyazaki, H. Daida (2004) Adiponectin and atherosclerotic disease. Clin. Chim. A. 344:1-12.
  • Smith J., M. Al-Amri, K. Cianflone (2006) Leptin and adiponectin in relation to body fat percentage, waist to hip ratio and the apoB/apoAI ratio in Asian Indian and Caucasian men and women. BMC Nutrition and Metabolism 3:18. (http://www.nutritionandmetabolism.com/ [Crossref]
  • Vincent S., P. Berthon. H. Zouhal, E. Moussa, M. Catheline, D. Bentuè-Ferrer, A. Gratas-Delamarche (2003) Plasma glucose, insulin and catecholamine responses to a Wingate test in physically active women and men. Eur.J. Appl. Physiol. 91:15-21.
  • Vital P., E. Larietta, M. Hiriart (2006) Sexual dimorphism in insulin sensitivity and susceptibility to develop diabetes in rats. J. Endocrinol. 190:425-432.
  • Wasim H., N. M. Al-Daghrin, R. Chetty, P. G. McTernan, A. H. Barnett, S. Kumar (2006) Relationship of serum adiponectin and resistin to glucose intolerance and fat topography in south-Asians. BMC Cardiovasc. Diabetol. 5:10 (http://www.cardiab.com/
  • Więcek A, M. Adamczak, J. Chudek (2007) Adiponectin - an adipokine with unique metabolic properties. Nephrol. Dial. Transplant. 22:981-988.[Crossref][PubMed][WoS]
  • Williams Ch. (2004) Lipid metabolism in women. Proc. Nutr. Soc. 63:153-160.[PubMed][Crossref]
  • Xu A., Y. Wang, H. Keshaw, L. Yi Xu, K. S. L. Lam, G. J. S. Cooper (2003) The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver disease in mice. J. Clin. Invest. 112:91-100.[Crossref]

Document Type

Publication order reference


YADDA identifier

JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.