The present study aims at assessing the relationship between airway resistance indexes (FEV1, FVC and FEV1/FVC) and maximal oxygen uptake (Vo2max) in young adults. Subjects of the study included 50 healthy males (age, 22.1 ± 2.47 years; FEV1, 3.41 ± .66 liter; FVC, 3.96 ± .56 liter; VO2max, 38.83 ± 9.83 ml.kg-1.min-1) studying at Shahid Chamran University of Ahvaz. After determining subjects' volumes of FEV1, FVC and FEV1/FVC by digital spirometer, maximal oxygen uptake was measured. The study protocol measured VO2max levels using the sub-maximal Astrand-Ryming test on the ergometer cycle. The data were analyzed through descriptive and inferential statistics. Results revealed a significant correlation among the three independent variables of FEV1, FVC, FEV1/FVC and projected VO2max values. Based on the results, it can be concluded that these parameters have a close interaction with higher VO2max levels, and therefore, having a lower airway resistance seems beneficial.