PL EN


Preferences help
enabled [disable] Abstract
Number of results
2008 | 19 | 121-130
Article title

Serum Osteocalcin Concentration in Treadmill-Trained Adult Male Wistar Rats

Content
Title variants
Languages of publication
EN
Abstracts
EN
Mechanical stress is considered to be essential for the regulation of bone mass. The purpose of this study was to determine whether treadmill exercise at moderate intensity induces alterations in blood osteocalcin concentration in rats. Male Wistar rats, aged 5 months, were divided randomly into two groups: trained animals (n = 6) and controls (n = 7). Trained rats were exercised 5 days/week for 4 weeks on a motor-driven treadmill. Each exercise session lasted 60 minutes and the average locomotion speed was 16.2 m/min. After completion of the training period, a blood sample was taken for osteocalcin measurement and the hindlimbs medial gastrocnemius muscles were excised and weighed. Comparative analysis showed significantly lower circulating osteocalcin levels in the exercised rats in comparison to control animals. It is possible that the observed decreased blood osteocalcin concentration is transient in nature. Factors including stress may also influenced the results.Serum osteocalcin concentration in treadmill-trained rats
Keywords
Publisher

Year
Volume
19
Pages
121-130
Physical description
Dates
published
1 - 1 - 2008
online
24 - 10 - 2008
Contributors
author
  • Department of Hygiene, University School of Physical Education, Poznań
  • Department of Neurobiology, University School of Physical Education, Poznań
  • Department of Neurobiology, University School of Physical Education, Poznań
  • Department of Hygiene, University School of Physical Education, Poznań
References
  • Bourrin S., Genty C., Palle S., Gharib C., Alexandre C. (1994) Adverse effects of strenuous exercise: a densitometric and histomorphometric study in the rat. J. Appl.Physiol. 76: 1999-2005.
  • Brahm H., Ström H., Piehl-Aulin K., Mallmin H., Ljunghall S. (1997) Bone metabolism in endurance trained athletes: a comparison to population-based controls based on DXA, SXA, quantitative ultrasound, and biochemical markers. Calcif.Tissue Int. 61: 448-454.[PubMed][Crossref]
  • Carstanjen B., Amory H., Sulon J., Hars O., Remy B., Langlois P., Lepage O. M. (2005) Serum osteocalcin and CTX-MMP concentration in young exercising Thoroughbred racehorses. J. Vet.Med.A A52: 114-120.
  • Cohen A. H., Gans C. (1975) Muscle activity in rat locomotion: movement analysis and electromyography of the flexors and extensors of the elbow. J. Morph. 146: 177-196.[Crossref]
  • Eriksen E. F., Brixen K., Charles P. (1995) New markers of bone metabolism: clinical use in metabolic bone disease. Eur.J. Endocrinol. 132: 251-263.[PubMed][Crossref]
  • Ferretti J. L., Cointry G. R., Capozza R. F., Capiglioni R., Chiappe M. A. (2001) Analysis of biomechanical effects on bone and on the muscle-bone interactions in small animal models. J. Musculoskel.Neuron.Interact. 1: 263-274.
  • Fries J. F. (1996) Prevention of osteoporotic fractures: possibilities, the role of exercise, and limitations. Scand.J. Rheumatol. 25 (Suppl. 103): 6-10.
  • Frost H. M. (1992) Perspectives: bone's mechanical usage windows. Bone Mineral. 19: 257-271.[Crossref]
  • Frost H. M. (1997) Why do marathon runners have less bone than weight lifters? A vital biomechanical view and explanation. Bone 20: 183-189.[Crossref][PubMed]
  • Frost H. M., Jee W. S. S. (1992) On the rat model of human osteopenias and osteoporoses. Bone Miner. 18: 227-236.[Crossref][PubMed]
  • Frost H. M., Schönau E. (2000) The "muscle-bone unit" in children and adolescents: a 2000 overview. J. Ped.Endocrinol.Metab. 13: 571-590.
  • Fujie H., Miyagaki J., Terrier A., Rakotomanana L., Leyvraz P. F., Hayashi K. (2004) Detraining effects on the mechanical properties and morphology of rat tibiae. Biomed.Mater.Eng. 14: 219-233.[PubMed]
  • Goseki M., Omi N., Oida S., Ezawa I., Sasaki S. (1995) Voluntary exercise increases osteogenetic activity in rat bones. Bull. Tokyo Med.Dent.Univ. 42: 1-8.[PubMed]
  • Holy X., Zérath E. (2000) Bone mass increase in less than 4 wk of voluntary exercising in growing rats. Med.Sci.Sports Exerc. 32: 1562-1569.
  • Iwamoto J., Shimamura C., Takeda T., Abe H., Ichimura S., Sato Y., Toyama Y. (2004) Effects of treadmill exercise on bone mass, bone metabolism, and calciotropic hormones in young growing rats. J. Bone Miner.Metab. 22: 26-31.[Crossref]
  • Jee W. S. S., Li X. J., Ke H. Z. (1991) The skeletal adaptation to mechanical usage in the rat. Cells Mater. 1(Suppl): 131-142.
  • Kannus P., Jozsa L., Kvist M., Jarvinen T. L., Maunu V. M., Hurme T., Jarvinen M. (1996) Expression of osteocalcin in the patella of experimentally immobilized and remobilized rats. J. Bone Miner.Res. 11: 79-87.
  • Kaspar D., Seidl W., Neidlinger-Wilke A., Ignatius A., Claes L. (2000) Dynamic cell stretching increases human osteoblast proliferation and CICP synthesis but decreases osteocalcin synthesis and alkaline phosphatase activity. J. Biomech. 33: 45-51.[Crossref]
  • Li K. C., Zernicke R. F., Barnard R. J., Li A. F.-Y. (1991) Differential response of rat limb bones to strenuous exercise. J. Appl.Physiol. 91: 554-560.
  • MacDougall J. D., Webber C. E., Martin J. S., Ormerod S., Chesley A., Younglay E. V., Gordon C. L., Blimkie C. J. (1992) Relationship among running mileage, bone density and serum testosterone in male runners. J. Appl.Physiol. 73: 1165-1170.
  • May H., Murphy S., Khaw K. T. (1994) Age-associated bone loss in men and women and its relationship to weight. Age Aging 23: 235-240.[Crossref]
  • McDonald R., Hegenauer J., Saltman P. (1986) Age-related differences in the bone mineralization pattern of rats following exercise. Gerontol. 41: 445-452.[Crossref]
  • Mosekilde L., Danielsen C. C., Sogaard C. H., Thorling E. (1994) The effect of long-term exercise on vertebral and femoral bone mass, dimensions, and strength - assessed in a rat model. Bone 15: 293-301.[Crossref]
  • Newhall K. M., Rodnick K. J., van der Meulen M. C., Carter D. R., Marcus R. (1991) Effects of voluntary exercise on bone mineral content in rats. J. Bone Miner.Res. 6: 289-296.
  • Nielsen B. D., Potter G. D., Greene L. W., Morris E. L., Murray-Gerzik M., Smith W. B., Martin M. T. (1998) Characterization of changes related to mineral balance and bone metabolism in the young racing Quarter Horse. J. Equine Vet.Sci. 18: 190-200.[Crossref]
  • Pedersen B. J., Schlemmer A., Hassager C., Christiansen C. (1995) Changes in the carboxyl-terminal propeptide of type I procollagen and other markers of bone formation upon five days of bed rest. Bone 17: 91-95.[PubMed][Crossref]
  • Pogrzebna M., Celichowski J. (2005) The influence of endurance training on contractile properties of motor units in the rat medial gastrocnemius muscle. Acta Neurobiol.Exp. 65: 332.
  • Rubin C. T., Lanyon L. E. (1987) Osteoregulatory nature of mechanical stimuli: Function as a determinant for adaptive remodeling in bone. J. Orthop.Res. 5: 300-310.[Crossref]
  • Schönau E., Werhahn E., Schiedermaier U., Mokow E., Schiessl H., Scheidhauer K., Michalk D. (1996) Influence of muscle strength on bone strength during childhood and adolescence. Horm.Res. 45(Suppl. 1): 63-66.
  • Seburn K. L., Gardiner P. (1995) Adaptations of rat lateral gastrocnemius motor units in response to voluntary running. J. Appl.Physiol. 78: 1673-1678.
  • Singh R., Umemura Y., Honda A., Nagasawa S. (2002) Maintenance of bone mass and mechanical properties after short-term cessation of high impact exercise in rats. Int.J. Sports Med. 23: 77-81.[PubMed][Crossref]
  • Sogaard C. H., Danielsen C. C., Thorling E. B., Mosekilde L. (1994) Long-term exercise of young and adult female rats: Effects on femoral neck biomechanical competence and bone structure. J. Bone Min.Res. 9: 409-416.
  • Tokuyama K., Saito M., Okuda H. (1982) Effects of wheel running on food intake and weight gain of male and female rats. Physiol.Behav. 28: 899-903.[PubMed][Crossref]
  • Verborgt O., Gibson G. J., Schaffler M. B. (2000) Loss of osteocyte integrity in association with microdamage and bone remodeling after fatigue in vivo. J. Bone Miner.Res. 15: 60-67.[Crossref]
  • Warner S. E., Shea J. E., Miller S. C., Shaw J. M. (2006) Adaptations in cortical and trabecular bone in response to mechanical loading with and without weight bearing. Calc.Tissue Int. 79: 395-403.[Crossref]
  • Wheeler D. L., Graves J. E., Miller G. J., Griend R. E. V., Wronski T. J., Powers S. K., Park H. M. (1995) Effects of running on the torsional strength, morphometry, and bone mass of the rat skeleton. Med.Sci. Sports Exerc. 27: 520-529.[PubMed]
  • Yeh J. K., Aloia J. F., Chen M. M., Tierney J. M., Sprintz S. (1993) Influence of exercise on cancellous bone of aged female rat. J. Bone Miner.Res. 8: 1117-1125.
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.-psjd-doi-10_2478_v10078-008-0009-7
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.