Blood-Brain Barrier and Exercise – a Short Review
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Blood-brain barier (BBB) segregates central nervous system (CNS) from the circulating blood. BBB is formed by the brain capillary endothelial cells with complex tight junctions between them as well as by astrocytes and pericytes. BBB is responsible for transport of selected chemicals into and out of the CNS as well as for its protection from fluctuations in plasma composition following meals, during exercise and from circulating agents such as neurotransmitters, xenobiotics and other potentially harmful substances capable to disturb neural function. BBB may be compromised during CNS injury, infection, fever and in some nerodegenerative diseases. The increase of BBB permeability was observed also during exercise as documented by changes of plasma S-100 protein levels, used as a peripheral marker of BBB integrity. Marked change in BBB integrity during exercise may disturb normal brain function and contribute to the development of central fatigue. Moreover, serum S-100β may indicate level of injury in individuals suffering brain injuries during sports. There are also data suggesting that acute effect of physical exercise on serum S100β levels may not be related with CNS injury. Further studies to establish whether training and which type of it may modulate BBB permeability are needed.
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24 - 10 - 2008
- Department of Physiology, Academy of Physical Education, Katowice, Poland
- Medical Rehabilitation Ward, St. Barbara Voivodship Hospital No 5, Sosnowiec, Poland
- Department of Cellular Signaling, Medical Research Center, Polish Academy of Sciences, Warsaw, Poland
- Department of Physiology, Academy of Physical Education, Katowice, Poland
- Abbot N. J. (2002) Astrocyte-endothelial interactions and blood-brain barrier permeability. J Anat. 200, 629-638.
- Abbott N. J. (2005) Dynamics of the CNS barriers: evolution, differentiation, and modulation. Cell. Mol. Neurobiol. 25, 5-23.[PubMed][Crossref]
- Abbott N. J. (1998) In: Introduction to the Blood-Brain Barrier: Methodology and Biology. Ed. Pardridge W. M., Cambridge Univ. Press, Cambridge, 345-353.
- Ballabh P., Braun A., Nedergaard M. (2004) The blood-brain barrier: an overview. Structure, regulation, and clinical implications. Neurobiol. Dis. 16, 1-13.[Crossref][PubMed]
- Brancaccio P., Maffulli N., Limongelli F. M. (2007) Creatine kinase monitoring in sport medicine. Br. Med. Bull. 82, 209-230.[WoS]
- Broadwell R. D., Charlton H. M., Ebert P., Hickey W. F., Villegas J. C., Wolf A. L. (1990) Angiogenesis and the blood-brain barrier in solid and dissociated cell grafts within the CNS. Prog. Brain Res. 82, 95-101.
- Brown R. C., Mark K. S., Egleton R. D. Davis T. P. (2003) Protection against hypoxia-induced increase in blood-brain barrier permeability: role of tight junction proteins and NFκB. J. Cell. Sci. 116, 693-700.
- Chalimoniuk M., Wroński Z., Gilewski K., Stolecka A., Langfort J. (2005) Does exercise training affect NO/GC/cGMP patway In the brain? J. Hum. Kinetics 13, 27-40.
- Chaudhuri J. D. (2000) Blood-brain barrier and infection. Med. Sci. Monit. 6, 1213-1222.[PubMed]
- Dalsgaard M. K., Quistroeff B., Danielsen E. R., Semler C., Vogelsang T., Secher N. H. (2004) Areduced cerebral metabolic ratio in exercise reflects metabolism and not accumulation of lactate within the brain. J. Physiol. 554, 571-578.
- Davis J. M., Bailey S. P. (1997) Possible mechanisms of central nervous fatigue during exercise. Med. Sci. Sports Exerc. 29, 45-47.
- Dietrich M. O., Tort A. B., Schaf D. V., Farina M., Gonclaves C. A., Souza D. O., Portela L. V. (2003) Increase in serum S100β protein level after a swimming race. Can. J. Appl. Physiol. 28, 710-716.
- Gloor S. M., Wachtel M., Bolliger M. F., Ishihara H., Landmann R., Frei K. (2001) Molecular and cellular permeability control at the brai-blood barrier. Brai Res Brain Res Rev, 36, 258-264.
- Griffin W. S., Stamley L. C., Ling C., White L., Macleod V., Perrot L. J., White J. C., Araoz C. (1989) Brain interleukin 1 and S-100 immunoreactivity are elevated in down syndrome and Alzheimer disease. Proc Natl., Acad. Sci. USA 86, 7611-7615.[Crossref]
- Himeda T., Watanabe Y., Tounai H., Hayakawa N., Kato H., Araki T. (2006) Time dependent alterations of co-localisation of S100β and GFAP in the MPTP-treted mice. J. Neural Transm. 113, 1887-1894.
- Ide K., Horn A., Secher N. (1999) Cerebral metabolic response to submaximal exercise. J. Physiol 522, 159-164.
- Isobe T., Takahashi K., Okuyama T. (1984) S-100aα (alpha alpha) protein is present in neurons of the central nervous system. J Neurochem, 43, 1494-1496.
- Kapural M., Krizanac-Bengez L., Barnett G., Perl J., Masaryk T., Apollo D., Rasmussen P., Mayberg M. R., Janigro D. (2002) Serum S-100β as a possible marker of blood-brain barrier disruption. Brain Res. 940, 102-104.
- Karen S., Davis P. (2002) Cerebral microvascular changes in permability and tight junctions induced by hypoxia-reoxygenation. Am. J. Physiol. Heart Circ. Physiol. 282, 1485-1494.
- Kiełbiński M., Sołtys Z. (2008) S100 protein, astrocytes and memory. Post. Biol. Kom, 35, 3-13
- Magistretti P. J. (2006) Neuron-glia metabolic coupling and plasticity. J. Exp. Boil. 209, 2304-2311.
- Kobayashi H., Magnoni M. S., Govoni S., Izumi F., Wada A., Trabucchi M. (1985) Neuronal control of brain microvessel function. Experientia 41, 427-434.[PubMed][Crossref]
- Li J., Ding Y-H., Rafols JA., Lai Q., McAllister II JP., Ding Y. (2005) Increased astrocyte proliferation in rats after running exercise. Neurosci. Lett. 386. 160-164.
- Maramatsu Y., Kurosaki R., Kato H., Araki T. (2004) Effect of pitavastatin against expression of S1beta protein In the gerbil hippocampus after transient cerebral ischemia. Acta.Physiol. Scand. 182, 95-107.
- Maramatsu Y., Kurosaki R., Watanabe H., Michimata M., Matsubara M., Imai Y., Araki T. (2003) Expression of S100beta protein is related to neuronal damage in MPTP-treated mice. Glia 42, 307-313.[Crossref]
- Marchi N., Rasmussen P., Kapural M., Fazio V., Kight K., Mayberg M. R., Kanner A., Ayumar B., Albensi B., Cavaglia M., Jangro D. (2003) Peripheral markers of brain damage and blood-brain barrier dysfunction. Restor. Neurol. Neurosci. 21, 109-121.
- Matsui T., Mori T., Tateishi N., Kagamiishi T., Satoh S., Katube N., Morikawa E., Morimoto T., Ikuta F., Asano T. (2002) Astrocytic activation and delayed infarct expansion after permanent focal ischemia in rats: Part I: enhanced astrocytic synthesis of s-100beta in periinfarct area precedes delayed infarct expression. J. Cereb. Blood Flow Metab. 22, 711-722.[PubMed]
- Migheli A., Cordera S., Bendotti C., Atzori C., Piva R., Schiffer D. (1999) S-100beta protein is upregulated in astrocytes and motor neurons in the spinal cord of patients with amyotrophic lateral sclerosis. Neurosci. Lett. 261, 25-28.
- Mooren F. C., Lechtermann A., Fobker M., Brandt B., Sorg C., Volker K., Nacken W. (2006) The response of the novel pro-inflamatory molecules S100A8/A9 to exercise. Int. J. Sports Med. 27, 751-758.
- Otto M., Holthusen S., Bahn E., Söhnchen N., Wiltfang J., Geese R., Fischer A., Reimers C. D. (2000) Boxing and running lead to a rise in serum levels of S-100β protein. Int. J. Sports Med. 21, 551-555
- Sendrowski K., Sobaniec W., Sobaniec-Łotowska M. E., Lewczuk P. (2004) S-100 protein as marker of the blood-brain barrier disruption in children with internal hydrocephalus and epilepsy - a preliminary study. Roczniki Akademii Medycznej w Białymstoku, 49.
- Sheng J. G., Mark RE., Griffin WS. (1997) Glial-neuronal interactions in Alzheimer disease: progressive association of IL-1alpha+microglia and S100beta+astrocytes with neurofibrillary tangle stage. J. Neuropathol. Exp. Neurol. 56, 285-290.
- Watson P., Black K. E., Clark S. C., Maughan R. J. 2006. Exercise in the heat: effect of fluid ingestion on blood-brain barrier permeability. Med. Sci. Sports Exerc. 38, 2118-2124.
- Watson P., Shirreffs S., Maughan R. J. (2005) Blood-brain barrier may be threatened by exercise in a warm environment. Am. J. Physiol. Regul. Integr. Physiol. 288, 1689-1694.
- Yamamoto T., Newsholme E. A. (2000) Diminished central fatigue by inhibition of the L-system transporter for the uptake of tryptophan. Brain Res. Bull. 52, 35-38.
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