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2009 | 64 | 291-299

Article title

Comparision of methods used for estimation of lipophilicity of biologically active phenylthioamides

Authors

Content

Title variants

Languages of publication

EN

Abstracts

EN
Effectiveness of compound actions on living organisms depends on optimal lipophilicity. For studied 2,4-dihydroxyphenylthioamides of microbiocidal properties there were determined the values of lipophilicity parameters: log kw, using high performance liquid chromatography and log P - the theoretical distribution coefficient in the n-octanol/water system. The search for a theoretical method was made which could replace chromatographic methods in preliminary choice of compounds of presumably high fungicidal activity.The obtained results point to the Crippens and Ghose method and the values log P determined in this way correlate well with log kw and allow to choose a lipophilicity range in which the biological activity is the largest.

Keywords

Year

Volume

64

Pages

291-299

Physical description

Dates

published
1 - 1 - 2009
online
22 - 1 - 2010

Contributors

author
  • Departament of Chemistry, University of Nature, ul. Akademicka 15, 20-031 Lublin, Poland

References

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  • A. Niewiadomy, J. Matysiak, G. Mącik-Niewiadomy, Biul. U. Pat. P-330263, (2000).
  • A. K. Ghose, G. M. J. Crippen, Chem. Inf. Comput. Sci. 27, 21-35 (1987).
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  • A. Żabińska, J. K. Różyło, J. Matysiak, A. Niewiadomy, Journal of Planar Chromatography. 13, 420-425 (2000).
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Document Type

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.-psjd-doi-10_2478_v10063-008-0022-7
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