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Journal

2011 | 12 | 1 | 95-99

Article title

Complement Proteins (C1est, C4, C6), Circulating Immune Complexes and the Repeated Bout Effect

Content

Title variants

Languages of publication

EN

Abstracts

EN
Purpose. To determine if the complement system is activated following strenuous eccentrically-biased exercise. Secondly, to determine if complement activation is attenuated (repeated bout effect) following a second bout of the same exercise. Basic procedures. Healthy, active but untrained males performed 2 × 60 min bouts of downhill running, 14 days apart. Samples were taken pre, immediately post (IP), then every hour for twelve hours, and at 24, 48, 72, 96, 120 and 144 h post exercise. Concentrations of C1est, C4, and circulating immune complexes (CIC's) were determined using standardised nephelometery. C6 was determined using radial immunodifusion. The variables were analysed using a repeated measures ANOVA, with significance set at p < 0.05. Main findings. A significant (p < 0.01) run effect was observed for C1est, C4, C6 and CIC's with the concentrations elevated after run 2 compared with run 1. C1est and C4 exhibited significant time effects (p < 0.001). Conclusions. The complement system is activated following a strenuous bout of downhill running. Complement proteins and circulating immune complexes do not exhibit the same traditional ‘repeated bout effect’ as many other common markers of muscle damage/inflammation. The increase in complement proteins following the second bout may indicate enhanced innate immune function and/or an amplification of the immune response to tissue damage through interaction with the adaptive immune system.

Publisher

Journal

Year

Volume

12

Issue

1

Pages

95-99

Physical description

Dates

published
1 - 3 - 2011
online
14 - 3 - 2011

Contributors

author
author
author
  • Department of Sport, Rehabilitation and Dental Sciences, Tshwane University of Technology, Pretoria, South Africa
  • Department of Immunology, School of Pathology, NHLS, University of Witwatersrand, Johannesburg, South Africa
author
  • Department of Immunology, School of Pathology, NHLS, University of Witwatersrand, Johannesburg, South Africa

References

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Document Type

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.-psjd-doi-10_2478_v10038-010-0026-y
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