Purpose. The study investigated acute cardiovascular alterations during aerobic exercise in interdialytic phase. Basic procedures. Seven hypertensive men with chronic renal disease (CRD) and seven healthy men (C) were matched according to the age (CRD: 48.5 ± 8.5; C: 45.28 ± 9.3) and body mass index (CRD: 24.2 ± 2.8 kgm-2; C: 26.7 ± 2.7 kgm-2). The exercise was executed on a cycloergometer during 6 minutes at 75% of HRmax and 3 minutes of recovery without load at 55 - 60 rpm. The patients came twice and were controlled only on an occasion at the hospital at 9.00 am. The exercise was performed before and 24 hours after haemodialysis (HD). The blood samples were drawn immediately before and 24 hours after HD for hematocrit and hemoglobin analysis. The statistical difference was verified by the ANOVA and two-tailed unpaired Student's t-test only for p < 0.05. Main findings. After HD, the systolic blood pressure (SBP) shows reduction in the first stage (~14%; p < 0.05) and in the recovery period of exercise (~18%; p < 0.05). A hypotension effect of HD was better observed in the diastolic blood pressure (DBP) from the 5th to 9th min of exercise (~20%; p < 0.05). The HD did not modify biochemical (hematocrit and hemoglobin), physiological (Rest SpO2; rest SBP; rest DBP and VO2max) and body weight parameters. Conclusions. The study showed a significant reduction in blood pressure levels during the exercise, principally in DBP 24 hours after HD, suggesting that exercise executed during this period can induce better tolerance to exercise in dialyzed patients.