Prevalence and Progression of Acute Pancreatitis in the Świętokrzyskie Voivodeship Population

• Authors: Stanisław Głuszek , Dorota Kozieł
• Languages of publication: EN

Abstracts

EN

Acute pancreatitis (AP) is a significant clinical problem. There have been no prospective epidemiological data on AP in Poland. The aim of this study is to estimate prevalence, etiology and severity of acute pancreatitis in the Świętokrzyskie Voivodeship population, involving risk factors of this disease.Material and methods. In 2011 prospective observation was conducted in all departments of surgery of the Świętokrzyskie Voivodeship. The inclusion criterion of the study, a definite diagnosis of AP, was met in 1044 hospitalized patients. According to our assumption that repeated hospitalization is considered as a new case if occurred more than 60 days after the previous one, 1004 patients were included in the further analysis.Results. The incidence rate was 99.96/100,000. Incidence rate among woman was 72/100,000 and incidence among men was 130.24/100,000 (p < 0.05). Median age of AP patients was 53 years. Median age among woman (65 years) was significantly (p < 0.005) higher than among man (47 years). Incidence rate for the first episode was 79.7/100,000 citizens. Main causes of AP included cholelithiasis (30.1%), alcohol (24.1%), coexisting cholelithiasis and alcohol abuse (2.9%), pancreatic cancer (1%), AP after ERCP (0.7%). Basing on modified Atlanta criteria, severe AP was diagnosed in 7%, moderate in 12.3%, and mild in 80.7% of patients. Mean duration of hospitalization of patients with severe AP was 14.8, moderate - 16,7, mild - 7.1 days. Mortality rate for AP was 3.9%. Mean age of deceased women was 74 years and was significantly higher than in the group of men (61 years). Mortality rate in severe AP was 52.9% and was significantly (p < 0.05) higher than mortality in moderate (no deaths) or mild AP (0.2%).Conclusions. Incidence rate of AP in the Świętokrzyskie Voivodeship population is among the highest in Poland. Our study indicates that new Atlanta classification, that differentiates between moderate and severe AP, needs to be implemented to the clinical practice, since the latter carries high mortality in severe cases.

• Publisher: De Gruyter Open
• Journal: Polish Journal of Surgery
• Year: 2012
• Volume: 84
• Issue: 12
• Pages: 618-625

Dates

published

1 - 12 - 2012

online

09 - 02 - 2013

References

• 1. Appelros S, Borgström A: Incidence, aetiology and mortality rate of acute pancreatitis over 10 years in a defined urban population in Sweden. BrJ Surg 1999; 86: 465-70.[Crossref]
• 2. Jaakkola M, Nordback I: Pancreatitis in Finland between 1970 and 1989. Gut 1993; 34: 1255-60.
• 3. Eland IA, Sturkenboom MJ, Wilson JH et al.: Incidence and mortality of acute pancreatitis between 1985 and 1995. Scand J Gastroenterol 2000; 35:1110-16.
• 4. Irving HM, Samokhvalov AV, Rehm J: Alcohol as a Risk Factor for Pancreatitis. A Systematic Review and Meta-Analysis. JOP. J Pancreas 2009; 10: 387-92.
• 5. O’Farrell A, Allwright S, Toomey D et al.: Hospital admission for acute pancreatitis in the Irish population, 1997-2004: could the increase be due to an increase in alcohol-related pancreatitis? JPublic Health 2007; 29: 398-404.
• 6. Birgisson H, Möller PH, Birgisson S et al.: Acute pancreatitis: a prospective study of its incidence, aetiology, severity, and mortality in Iceland. EurJ Surg 2002; 168: 278-82.[Crossref]
• 7. Yadav D, Lowenfels AB: Trends in the epidemiology of the first attack of acute pancreatitis: a systematic review. Pancreas 2006; 33: 323-30.[Crossref]
• 8. Spanier BW, Dijkgraaf MG, Bruno MJ: Epidemiology, aetiology and outcome of acute and chronic pancreatitis: An update. Best Pract Res Clin Gastroenterol 2008; 22: 45-63.[WoS][Crossref]
• 9. Tonsi AF, Bacchion M, Crippa S, Malleo G et al.: Acute pancreatitis at the beginning of the 21st century: The state of the art. World J Gastroenterol 2009; 28; 15: 2945-59.[Crossref][WoS]
• 10. Guo-Jun Wang GJ, Chun-Fang Gao, Dong Wei et al.: Acute pancreatitis: Etiology and common pathogenesis. World J Gastroenterol 2009 28; 15: 1427-30.[WoS]
• 11. Sosnowski Z, Głuszek S: Ocena następstw zmian w postępowaniu rozpoznawczo-leczniczym u chorych na ostre zapalenie trzustki w latach 1995-2005. Przegl Gastroenterol 2009; 4: 308-15.
• 12. Panek J: Hipertriglicerydemia i ostre zapalenie trzustki. Chirurgia Polska 2001; 3(2): 97-104.
• 13. Yadav D, Pitchumoni C S: Issues in hyperlipidemic pancreatitis. J Clinic Gastroenterol 2003; 36: 54-62.
• 14. Lloret LC, Pelletier AL, Czernichow S et al.: Acute pancreatitis in a cohort of 129 patients referred for severe hypertriglyceridemia. Pancreas 2008; 37: 13-22.
• 15. Lankish PG, Dröge M, Gottesleben F: Drug induced acute pancreatitis: incidence and severity. Gut 1995;37: 565-7.[Crossref]
• 16. Spanier B M, Tuynman H, Hulst R, et al: Acute pancreatitis and concomitant use of pancreatitisassociated drugs. Am J Gastroenterol 2011; 106: 2183-88.[WoS][Crossref]
• 17. Somasekar K, Foulkes R, Morris-Stiff G et al.: Acute pancreatitis in the elderly- Can we perform better?. The Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland 2010; 9: 305-08.[WoS]
• 18. Lowenfeld A, Maisonneuve P, Sullivan T: The changing character of acute pancreatitis: epidemiology, etiology, and prognosis. Curr GastroenterolRep 2009; 11: 97-103.[Crossref]
• 19. Lund H, Tønnesen H, Tønnesen MH, Olsen O: Long-term recurrence and death rates after acute pancreatitis Scandinavian. J Gastroenterol 2006; 41: 234-38.
• 20. http://www.stat.gov.pl/cps/rde/xbcr/gus/PUBL_rs_rocznik_demograficzny_2011.pdf
• 21. https://prog.nfz.gov.pl/APP-JGP/Start.aspx
• 22. http://www.statystyka.medstat.waw.pl/wyniki/TabelaEurostat2010szac.htm
• 23. Report from European Pancreatic Club 41st Meeting Szeged AND (Hungary) AND, July 1-3,2009, Part II de-Madaria E, Soler-Sala G, Lopez- Font I, Zapater P, Martínez J, Gómez-Escolar L, Sánchez-Fortún C, Sempere L, Pérez-López J, Lluís F, Pérez-Mateo M. Update of the Atlanta Classification of severity of acute pancreatitis: should a moderate category be included? Pancreatolog 2010; 10: 613-9.
• 24. R oberts S E, Williams J G, Meddings D et al.: Incidence and case fatality for acute pancreatitis in England: geographical variation, social deprivation, alcohol consumption and aetiology - a record linkage study. Aliment Pharmacol Ther 2008; 931-94.[WoS]
• 25. Bogdan J, Elsaftawy A, Kaczmarzyk J, JabłeckiJ: Charakterystyka epidemiologiczna ostrego zapalenia trzustki w powiecie trzebnickim. PolPrzegl Chir 2012; 84: 120-30.
• 26. Huang KH, Lin P, Nie SL et al.: The epidemiological and clinical characteristics of 1316 cases of acute pancreatitis in Guangdong region. ZhonghuaNei Ke Za Zhi (Chinese Journal of Internal Medicine) 2007; 46: 831- 34.
• 27. Gislason H, Horn A, Hoem D et al.: Acute pancreatitis in Bergen, Norway. A study on incidence, etiology and severity. Scand J Surg 2004; 93: 29-33.
• 28. T akeyama Y: Long-Term Prognosis of Acute Pancreatitis in Japan. Clin Gastroenterol Hepatol 2009; 7: S15-S17.[WoS]
• 29. Jasień Z, Durlik M: Współczesne postępowanie chirurgiczne w ostrym zapaleniu trzustki. PrzeglGastroenterol 2006; 1: 146-50.
• 30. Sieklucki J, Krześniak N: Postępowanie w ostrym zapaleniu trzustki - doświadczenia Kliniki Chirurgii. Postępy Nauk Medycznych 2009; 3: 180-184.
• 31. Tinto A, Lloyd DA, Kang J-Y et al.: Acute and chronic pancreatitis - diseases on the rise: a study of hospital admissions in England 1989⁄90-1999⁄2000. Aliment Pharmacol Ther 2002; 16: 2097-05.
• 32. Pérez-Mateo M. How We Predict the Etiology of Acute Pancreatitis. JOP. J Pancreas 2006; 7: 257-61.
• 33. Andriulli A, Loperfido S, Napolitano G et al.: Incidence Rates of Post-ERCP Complications: A Systematic Survey of Prospective Studies American Journal of Gastroenterology 2007; 102: 1781-88.[Crossref]
• 34. Kostrzewska M, Baniukiewicz A, Wroblewski E, et al.: Complications of endoscopic retrograde cholangiopancreatography (ERCP) and their risk factors. Advances In Medical Sciences 2011; 56: 6-12.[PubMed][WoS]
• 35. Hammel P, Soufir N, Levy P et al.: Detection of CDKN2A, CDK and BRCA2 genes in patients with familial pancreatic cancer. Pancreatology 2009; 9: 463.
• 36. Talukdar R, Vege SS, Chari S et al.: Moderately severe acute pancreatitis: a prospective validation study of this new subgroup of acute pancreatitis. Pancreatology 2009; 9: 434.

Identifiers

DOI

10.2478/v10035-012-0102-4