Synchronous occurrence of multiple focal nodular hyperplasia and huge hepatic Perivascular epithelioid cells tumor (PEComa) in young woman after oral contraceptive use – is there a common pathogenesis?

• Authors: Adam Durczyński , Piotr Hogendorf , Dariusz Szymański , Stanisław Sporny , Janusz Strzelczyk
• Languages of publication: EN

Abstracts

EN

The association of focal nodular hyperplasia (FNH) and various neoplasms was described, but coincidence of multiple FNH and hepatic perivascular epithelioid cells tumor (PEComa) has not been reported. The clinical debate of oral contraceptive (OC) influence on FNH growth is ongoing, but no evidence exists about association of hepatic PEComa with OC use.Herein, we report a case of two FNH lesions and huge (150x100x80 mm) left hepatic lobe PEComa that occurred simultaneously in 18-year-old female with previous two year history of OC use, who underwent left hemihepatectomy and right hepatic FNH enucleation. Up to date, the patient has been followed-up for 65 months and remained disease-free.FNH and PEComa have a common vascular cytogenetic denominator. Our case raising a question of a causal relationship of FNH and PEComa with OC use that might be attributed to vascular changes. Future researches of larger sample sizes should further address this issue.

Keywords

EN

liver   perivascular epithelioid cells tumor   focal nodular hyperplasia   oral contraceptive  

• Publisher: De Gruyter Open
• Journal: Polish Journal of Surgery
• Year: 2012
• Volume: 84
• Issue: 9
• Pages: 457-460

Dates

published

1 - 10 - 2012

online

23 - 10 - 2012

References

• 1. Yoshihiko F, Osamu N, Akiko K et al.: Angioarchitecture and blood circulation in focal nodular hyperplasia of the liver. J Hepatol 1998; 29: 470-75.
• 2. Bonetti F, Pea M, Martignoni G et al.: PEC and sugar. Am J Surg Pathol 1992; 16: 307-08.[Crossref]
• 3. Strzelczyk JM, Durczynski A, Szymanski D et al.: Primary perivascular epithelioid cell tumor (PEComa) of the liver: report of a case. Surg Today 2009; 39(10): 916-21.[Crossref][PubMed]
• 4. Colle I, de Beeck BO, Hoorens A et al.: Multiple focal nodular hyperplasia. J Gastroenterol 1998; 33 (6): 904-08.[Crossref]
• 5. Paradis V, Laurent A, Flejou J-F et al.: Evidence for the polyclonal nature of focal nodular hyperplasia of the liver by the study of X-chromosome inactivation. Hepatol 1997; 26: 891-95.[Crossref]
• 6. Wanless IR, Albrecht S, Bilbao J et al.: Multiple focal nodular hyperplasia of the liver associated with vascular malformations of various organs and neoplasia of the brain. A new syndrome. Mod Pathol 1989; 2: 456-62.
• 7. Cohen C, Lawson D, DeRose PB: Sex and androgenic steroid receptor expression in hepatic adenomas. Hum Pathol 1998; 29: 1428-31.[Crossref][PubMed]
• 8. Lordan JT, Worthington TR , Quiney N et al.: Early postoperative outcomes following hepatic resection for benign liver disease in 79 consecutive patients. HPB 2009; 11(4): 321-25.[WoS][Crossref]
• 9. Mathieu D, Kobeiter H, Maison P et al.: Oral contraceptive use and focal nodular hyperplasia of the liver. Gastroenterol 2000; 118: 560-64.[Crossref]
• 10. Kapp N, Curtis KM : Hormonal contraceptive use among women with liver tumors: a systematic review. Contracept 2009; 80(4): 387-90.[Crossref]
• 11. Xiao X, Liu J, Sheng M: Synergistic effect of estrogen and VEGF on the proliferation of hemangioma vascular endothelial cells. J Pediatr Surg 2004; 39: 1107-10.[PubMed][Crossref]
• 12. Nahm CB, Ng K, Lockie P et al.: Focal nodular hyperplasia - a review of myths and truths. J Gastrointest Surg 2011; 15(12): 2275-83.[Crossref][WoS]
• 13. Fletcher CDM, Unni KK , Mertens F: Pathology and genetics of tumors of soft tissue and bone. Lyon: IARC Press, 2002; 221-22.
• 14. Hsee LC , McCall JL, Koea JB: Focal nodular hyperplasia: what are the indications for resection? HPB (Oxford) 2005; 7(4): 298-302.[PubMed]
• 15. Gutweiler JR, Yu DC, Kim HB et al.: Hepatoblastoma presenting with focal nodular hyperplasiaafter treatment of neuroblastoma. J Pediatr Surg 2008; 43: 2297-2300.[Crossref][WoS]

Identifiers

DOI

10.2478/v10035-012-0078-0