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2012 | 84 | 9 | 457-460

Article title

Synchronous occurrence of multiple focal nodular hyperplasia and huge hepatic Perivascular epithelioid cells tumor (PEComa) in young woman after oral contraceptive use – is there a common pathogenesis?

Content

Title variants

Languages of publication

EN

Abstracts

EN
The association of focal nodular hyperplasia (FNH) and various neoplasms was described, but coincidence of multiple FNH and hepatic perivascular epithelioid cells tumor (PEComa) has not been reported. The clinical debate of oral contraceptive (OC) influence on FNH growth is ongoing, but no evidence exists about association of hepatic PEComa with OC use.Herein, we report a case of two FNH lesions and huge (150x100x80 mm) left hepatic lobe PEComa that occurred simultaneously in 18-year-old female with previous two year history of OC use, who underwent left hemihepatectomy and right hepatic FNH enucleation. Up to date, the patient has been followed-up for 65 months and remained disease-free.FNH and PEComa have a common vascular cytogenetic denominator. Our case raising a question of a causal relationship of FNH and PEComa with OC use that might be attributed to vascular changes. Future researches of larger sample sizes should further address this issue.

Publisher

Year

Volume

84

Issue

9

Pages

457-460

Physical description

Dates

published
1 - 10 - 2012
online
23 - 10 - 2012

Contributors

  • Department of General and Transplant Surgery, Barlicki University Hospital in Łódź
  • Department of General and Transplant Surgery, Barlicki University Hospital in Łódź
  • Department of General and Transplant Surgery, Barlicki University Hospital in Łódź
  • Department of Dental Pathology, The Clinical-Didactic Centre in Łódź
  • Department of General and Transplant Surgery, Barlicki University Hospital in Łódź

References

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  • 2. Bonetti F, Pea M, Martignoni G et al.: PEC and sugar. Am J Surg Pathol 1992; 16: 307-08.[Crossref]
  • 3. Strzelczyk JM, Durczynski A, Szymanski D et al.: Primary perivascular epithelioid cell tumor (PEComa) of the liver: report of a case. Surg Today 2009; 39(10): 916-21.[Crossref][PubMed]
  • 4. Colle I, de Beeck BO, Hoorens A et al.: Multiple focal nodular hyperplasia. J Gastroenterol 1998; 33 (6): 904-08.[Crossref]
  • 5. Paradis V, Laurent A, Flejou J-F et al.: Evidence for the polyclonal nature of focal nodular hyperplasia of the liver by the study of X-chromosome inactivation. Hepatol 1997; 26: 891-95.[Crossref]
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  • 9. Mathieu D, Kobeiter H, Maison P et al.: Oral contraceptive use and focal nodular hyperplasia of the liver. Gastroenterol 2000; 118: 560-64.[Crossref]
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  • 12. Nahm CB, Ng K, Lockie P et al.: Focal nodular hyperplasia - a review of myths and truths. J Gastrointest Surg 2011; 15(12): 2275-83.[Crossref][WoS]
  • 13. Fletcher CDM, Unni KK , Mertens F: Pathology and genetics of tumors of soft tissue and bone. Lyon: IARC Press, 2002; 221-22.
  • 14. Hsee LC , McCall JL, Koea JB: Focal nodular hyperplasia: what are the indications for resection? HPB (Oxford) 2005; 7(4): 298-302.[PubMed]
  • 15. Gutweiler JR, Yu DC, Kim HB et al.: Hepatoblastoma presenting with focal nodular hyperplasiaafter treatment of neuroblastoma. J Pediatr Surg 2008; 43: 2297-2300.[Crossref][WoS]

Document Type

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.-psjd-doi-10_2478_v10035-012-0078-0
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