Synchronous occurrence of multiple focal nodular hyperplasia and huge hepatic Perivascular epithelioid cells tumor (PEComa) in young woman after oral contraceptive use – is there a common pathogenesis?

• Authors: Adam Durczyński , Piotr Hogendorf , Dariusz Szymański , Stanisław Sporny , Janusz Strzelczyk
• Languages of publication: EN

Abstracts

EN

The association of focal nodular hyperplasia (FNH) and various neoplasms was described, but coincidence of multiple FNH and hepatic perivascular epithelioid cells tumor (PEComa) has not been reported. The clinical debate of oral contraceptive (OC) influence on FNH growth is ongoing, but no evidence exists about association of hepatic PEComa with OC use.Herein, we report a case of two FNH lesions and huge (150x100x80 mm) left hepatic lobe PEComa that occurred simultaneously in 18-year-old female with previous two year history of OC use, who underwent left hemihepatectomy and right hepatic FNH enucleation. Up to date, the patient has been followed-up for 65 months and remained disease-free.FNH and PEComa have a common vascular cytogenetic denominator. Our case raising a question of a causal relationship of FNH and PEComa with OC use that might be attributed to vascular changes. Future researches of larger sample sizes should further address this issue.

Keywords

EN

liver; perivascular epithelioid cells tumor; focal nodular hyperplasia; oral contraceptive

• Publisher: De Gruyter Open
• Journal: Polish Journal of Surgery
• Year: 2012
• Volume: 84
• Issue: 9
• Pages: 457-460

Dates

published

1 - 10 - 2012

online

23 - 10 - 2012

Contributors

author

Adam Durczyński

• Department of General and Transplant Surgery, Barlicki University Hospital in Łódź

author

Piotr Hogendorf

• Department of General and Transplant Surgery, Barlicki University Hospital in Łódź

author

Dariusz Szymański

• Department of General and Transplant Surgery, Barlicki University Hospital in Łódź

author

Stanisław Sporny

• Department of Dental Pathology, The Clinical-Didactic Centre in Łódź

author

Janusz Strzelczyk

• Department of General and Transplant Surgery, Barlicki University Hospital in Łódź

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Identifiers

DOI

10.2478/v10035-012-0078-0