Melanoma of Unknown Primary as a Cause of Intestinal Obstruction - a Case Description
Languages of publication
Melanoma of unknown primary applies to 1-8% of all diagnosed melanomas, whereas primary melanoma of the small intestine is a extremely rare case. One of the melanoma characteristics is its capability of forming metastases in the small intestine which very often are diagnosed during autopsy.We present a case report of diagnosed melanoma of unknown primary, whose first symptom was intestinal obstruction. Before admission to the hospital cause of intestinal obstruction, the patient didn't present any signs and symptoms. All typical localizations of primary melanoma were excluded during diagnostic procedure. Palliative right hemicolectomy and segmental small intestine resection were performed. There were no complications in the postoperative course. On the ninth day the patient was discharged from hospital.Quick identification and radical resection of melanoma metastases in the alimentary tract may improve the survival rate in this group of patients. Resection, even if it is palliative by assumption, is not only the best method of elimination of persistent symptoms but it also gives hope for longer survival.
1 - 8 - 2012
17 - 9 - 2012
- Cormier JN, Xing Y, Feng L et al.: Metastatic melanoma to lymph nodes in patients with unknown primary sites. Cancer 2006; 106(9): 2012-20.
- Giuliano AE, Moseley HS, Morton DL: Clinical aspects of unknown primary melanoma. Ann Surg 1980; 191: 98-104.
- Anbari KK, Schuchter LM, Bucky LP et al.: Melanoma of unknown primary site: presentation, treatment, and prognosis a single institution study. Cancer 1997; 79: 1816-21.
- Mishima Y: Melanocytic and nevocytic malignant melanomas. Cellular and subcellular differentiation. Cancer 1967; 20: 632-49.
- Amar A, Jougon J, Edouard A et al.: Primary malignant melanoma of the small intestine. Gastroenterol Clin Biol 1992; 16: 365-67.
- Elsayed AM, Albahra M, Nzeako UC et al.: Malignant melanomas in the small intestine: a study of 103 patients. Am J Gastroeneterol 1996; 91: 1001-06.
- Sachs DL, Lowe L, Chang AE et al.: Do primary small intestinal melanomas exist? Report of a case. J Am Acad Dermatol 1999; 41: 1042-44.
- Blecker D, Abraham S, Furth E at al.: Melanoma in the gastrointestinal tract. Am J Gastroenterol 1999; 94: 3427-33.
- Patel JK, Didolkar MS, Pickren JW et al.: Metastatic patter of malignant melanoma: a study of 216 autopsy cases. Am J Surg 1978; 135: 807-10.
- DasGupta TK, Brasdield RD: Metastatic melanoma of gastrointestinal tract. Arch Surg 1964; 88: 969-73.
- Savoia P, Fava P, Osella-Abate S et al.: Melanoma of unknown primary site: a 33-year experience of the Turin Melanoma Centre. Melanoma Res 2010; 20(3): 227-32.[WoS]
- Rinne D, Baum RP, Hor G et al.: Primary staging and follow-up of high risk melanoma patients with whole-body 18F-fluorodeoxyglucose positron emission tomography: results of a retrospective study of 100 patients. Cancer 1998; 82(9): 1664-71.[Crossref]
- Bastiaannet E, Oyen WJG, Meijer S et al.: Impact of 18F. fluorodeoxyglucose positron emission tomography on surgical management of melanoma patients. Br J Surg 2006; 93(2): 243-49.[Crossref]
- Letsch A, Keilholz U, Schadendorf D et al.: Functional CCR9 expression in associated with small intestine metastases. J Invest Dermatol 2004; 122: 685-90.
- Albert JG, Gimm O, Stock K et al.: Small bowel endoscopy is crucial for diagnosis of melanoma metastases to the small bowel: a case of metachronous small bowel metastases and review of the literature. Melanoma Res 2007; 17: 335-38.[WoS]
- Agrawal S, Yao TJ, Coit DG: Surgery for melanoma metastatic to the gastrointestinal tract. Ann Surg Oncol 1999; 6: 336-44.[PubMed]
- Ollila DW, Essner R, Wanek LA et al.: Surgical resection for melanoma metastatic to the gastrointestinal tract. Arch Surg 1996; 131: 975-80.
- Wornom IL, Smith JW, Soong SJ et al.: Surgery as palliative treatment for distant metastases of melanoma Ann Surg 1986; 204: 181-85.
Publication order reference