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2012 | 84 | 6 | 313-316
Article title

Renal Carcinoma Metachronous Metastases to the Gall-Bladder and Pancreas - Case Report

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Renal carcinoma metastases to the gastrointestinal tract are seldom reported in medical literature. The study presented a case of a 76-year old female patient who underwent nephrectomy, due to T2N0M0 clear cell renal carcinoma and was additionally diagnosed with two metachronous metastases to the gall-bladder and pancreas. Abdominal ultrasound performed 32 months after nephrectomy demonstrated the presence of cholelithiasis and gall-bladder polyp. Laparoscopic cholecystectomy was performed. Clear cell renal carcinoma metastasis restricted to the gall-bladder mucosa was diagnosed on the basis of the histopathological examination. After surgery the patient remained under follow-up. In December, 2009 (47 months after nephrectomy) abdominal computer tomography (CT) revealed the presence of a tumor located in the tail of the pancreas. Distal pancreatic resection and splenectomy was performed. The histopathological examination confirmed the presence of clear cell renal carcinoma metastasis. The patient is in good general condition, under follow-up at the Oncological Outpatient Clinic.
Physical description
1 - 6 - 2012
28 - 7 - 2012
  • Department of Oncology, University Hospital in Cracow
  • Department of Surgery, Municipal Specialistic Hospital in Cracow
  • Department of Surgery, Municipal Specialistic Hospital in Cracow
  • Department of Surgery, Municipal Specialistic Hospital in Cracow
  • Rouviere O, Bouvier R, Negrier S et al.: Nonmetastatic renal cell carcinoma : is it really possible to define rational guidelines for post treatment follow up. Nat Clin Pract Oncol 2006; 3: 200-13.
  • Motzer RJ, Bander NH, Nanus DM: Renal -cell carcinoma. N Eng J Med 1996; 335: 865-75.[Crossref]
  • Sparwasser C, Krupienski M, Radomsky J et al.: Gall-bladder metastasis of renal cell carcinoma. A case report and review of the literature. Urol Int 1997; 4: 257-58.
  • Fullarton GM, Burgoyne M: Gall-bladder and pancreatic metastases from bilateral renal carcinoma presenting with hematobilia and anemia. Urology 1991; 2: 184-86.
  • Ricci V, Carbone SF, Testi W et al.: Single gall-bladder and multiple pancreatic metastases from renal cell carcinoma sixteen years after nephrectomy. Chir Ital 2008; 2: 311-314.
  • Cecka F, Jon B, Hatlova J et al.: Renal cell carcinoma metastatic to the pancreas: a single center experience. Hepatogastroenterology 2009; 56: 1529-32.
  • Chung PH, Srinivasan R, Linehan WM et al.: Renal cell carcinoma with metastases to the gall-bladder: Four cases from the National Cancer Institute (NCI) and review of the literature. Urol Oncol 2011; (w druku).[WoS]
  • Szabo KG, Szentkereszty Z, Toth LA et al.: Distal pancreas resection for metastasis of clear cell renal cancer. Magy Seb 2010; 63: 161-63.
  • Kitasato A, Tajima Y, Kuroki T et al.: Limited pancreatectomy for metastatic pancreatic tumors from renal cell carcinoma. Hepatogastroenterology 2010; 57: 354-57.[PubMed]
  • Pagano S, Ruggeri P, Franzoso F et al.: Unusual renal cell carcinoma metastasis to the gall-bladder. Urology 1995; 5: 867-69.[PubMed]
  • Limani K, Matos C, Hut F et al.: Metastatic carcinoma of the gall-bladder after a renal cell carcinoma. Acta Chir Belg 2003; 2: 233-34.[PubMed]
  • Ishizawa T, Okuda J, Kawanishi T et al.: Metastatic renal cell carcinoma of the gall-bladder. Asian J Surg 2006; 3: 145-48.[PubMed]
  • King DH, Centeno AS, Saldivar VA et al.: Renal cell carcinoma metastatic to the gall-bladder or prostate: two case reports. Urology 1995; 5: 722-25.[Crossref]
  • Pandey D, Kane SV, Shukia PJ et al.: Isolated gall-bladder metastasis from renal cell carcinoma. Indian J Gastroenterol 2006; 3: 161-62.
  • Park JS, Chae YS, Hong SJ et al.: Metastatic renal cell carcinoma of the gall-bladder. Yonsei Med J 2003; 2: 355-58.
  • Kucukakin B, Olsen CH, Gogenur I. Renal cell carcinoma with metachronous metastases to the gall-bladder after two years. Ugeskr Laeger 2009; 3: 2486-87.[PubMed]
  • Sellner F, Tykalsky N, De Santis M et al.: Solitary and multiple isolated metastases of clear cell renal carcinoma to the pancreas: an indication for pancreatic surgery. Ann Surg Oncol 2006; 1: 75-85.
  • Machada NO, Chopra P. Pancreatic metastasis from renal carcinoma managed by Whiplle resection. A case report and literature review of metastatic pattern surgical management and outcomes. JOP 2009; 4: 413-18.
  • Akatsu T, Shimazu M, Aiura K et al.: Clinicopathological features and surgical outcome of isolated metastasis of renal cell carcinoma. Hepatogastroenterology 2007; 78: 1836-40.
  • Wang J, Talmon GA, Feloney M et al.: Twelve-year survival after multiple recurrences and repeated metastasectomies for renal cell carcinoma. World J Surg Oncol 2011; 1: 155.
  • Masetti M, Zanini N, Martuzzi F et al.: Analysis of prognostic factors in metastatic tumors of the pancreas: a single-center experience and review of the literature. Pancreas 2010; 39: 135-43.[Crossref][WoS][PubMed]
  • Hijioka S, Hifumi M, Mekky MA et al.: Total pancreatectomy for metastatic renal cell carcinoma with marked extension into the main pancreatic duct. Inter Med 2010; 6: 557-62.[Crossref]
  • Barbaros U, Sumer A, Demirel T et al.: Single incison laparoscopic pancreas resection for pancreatic metastasis of renal cell carcinoma. JSLS 2010; 14: 566-70.[WoS][Crossref]
  • Gardini A, Morgagni P, Milandri C et al.: Pancreatic resection for metastases from renal cancer: long term outcome after surgery and immunotherapy approach - single center experience. Hepatogastroenterology 2012; 59: 687-90.[PubMed]
  • Ballarin R, Spaggiari M, Cautero N et al.: Pancreatic metastases from renal cell carcinoma: The state of the art. World J Gastroenterol 2011; 17: 4747-56.[Crossref]
  • Zerbi A, Ortolano E, Balzano G et al.: Pancreatic metastasis from renal cell carcinoma: which patients benefit from surgical resection? Ann Surg Oncol 2008; 4: 1161-68.
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