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2012 | 84 | 5 | 262-266

Article title

Hereditary Mixed Polyposis Syndrome - Own Experience


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Hereditary mixed polyposis syndrome (HMPS) is a rare condition of unknown genetic origin. The paper presents 25-year clinical follow up in a female patient with multiple gastrointestinal tract polyps of varied histology. They most likely served as sites of multiple colorectal cancers development. The clinical course is interesting in terms of diagnostics and therapy. The patient required extended genetic testing, intensive conservative treatment and numerous surgical procedures. This is the first case of HMPS presented in Polish publications.









Physical description


1 - 5 - 2012
4 - 7 - 2012


  • 2 Department of General and Gastroenterological Surgery, Medical University in Białystok
  • Laboratory of Medical Pathology, Medical University in Białystok
  • 2 Department of General and Gastroenterological Surgery, Medical University in Białystok


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  • Thomas HJ, Whitelaw SC, Cottrell SE et al.: Genetic Mapping of the Hereditary Mixed Polyposis Syndrome to Chromosome 6q. Am J Hum Genet 1996; 58: 770-76.
  • Cheah PY, Wong YH, Chau YP et al.: Germline Bone Morphogenesis Protein Receptor 1A Mutation Causes Colorectal Tumorigenesis In Hereditary Mixed Polposis Syndrome. Am J Gastroenterol 2009; 104: 3027-33.[Crossref]
  • Rozen P, Samuel Z, Brazowski E: A Prospective Study of the Clinical, Genetic, Screening, and Pathologic Features of a Family With Hereditary Mixed Polyposis Syndrome. Am J Gastroenterol 2003; 98: 2317-20.[Crossref][PubMed]
  • Cao X, Eu KW, Kumarasinghe MP et al.: Mapping of hereditary mixed polyposis syndrome (HMPS) to chromosome 10q23 by genomewide high-density single nucleotide polymorphism (SNP) scan and identification of BMPR1A loss of function. J Med Genet 2006; 43: e13.
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  • Brazowski E, Misonzhnick-Bedny F, Rozen P: Cyclooxygenase-2 Expression In the Hereditary Mixed Polyposis Syndrome. Did Dis Sci 2004; 49(11-12): 1906-11.[Crossref]
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