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2012 | 84 | 5 | 238-241
Article title

The -2518 A/G MCP-1 Polymorphism as a Risk Factor of Inflammatory Bowel Disease

Content
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Languages of publication
EN
Abstracts
EN
Inflammatory bowel diseases (IBD) are disorders originated from immune disturbances.The aim of the study was to evaluate the association between the -2518 A/G MCP-1 polymorphism and the risk of IBD development.Material and methods. Genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Study group consisted of 197 subjects with IBD (120 with ulcerative colitis and 77 with Crohn's disease) as well as 210 healthy controls.Results. The presence of the -2518 G/G MCP-1 genotype in the investigated groups seems to be connected with higher risk of inflammatory bowel disease as well as Crohn's disease only (OR 2.26; 95% CI 1.44-3.54 and OR 2.08; 95% CI 1.21-3.46, respectively).Conclusions. Our data showed that the -2518 A/G MCP-1 polymorphism might be associated with the IBD occurrence and might be used as predictive factor of these diseases in a Polish population.
Publisher

Year
Volume
84
Issue
5
Pages
238-241
Physical description
Dates
published
1 - 5 - 2012
online
4 - 7 - 2012
Contributors
author
  • Department of Clinical Chemistry and Biochemistry, Medical University in Łódź
  • Department of Clinical Chemistry and Biochemistry, Medical University in Łódź
author
  • Department of General and Colorectal Surgery, Medical University in Łódź
author
  • Department of General and Colorectal Surgery, Medical University in Łódź
  • Department of Gastroenterology and Internal Diseases, Medical University in Łódź
author
  • Department of Gastroenterology and Internal Diseases, Medical University in Łódź
author
  • Department of General and Colorectal Surgery, Medical University in Łódź
  • Department of Clinical Chemistry and Biochemistry, Medical University in Łódź
References
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.-psjd-doi-10_2478_v10035-012-0039-7
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