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2012 | 84 | 4 | 202-207

Article title

Serum Cystatin C in Relation to Fat Mass Loss After Bariatric Surgery"

Content

Title variants

Languages of publication

EN

Abstracts

EN
Serum cystatin C concentration, generally accepted as renal function marker, is associated with cardiovascular risk and metabolic syndrome. Recent studies indicate that cystatin C increases in human obesity and that adipose tissue contributes to enhanced serum cystatin C concentration in obese subjects.The aim of the study was to assess whether a reduction in body and fat mass after bariatric surgery has any impact on serum cystatin C concentrations.Material and methods. Serum from 27 obese patients were tested before and 6 months after bariatric surgery. Twenty healthy subjects with normal body weight served as controls. Serum cystatin C concentrations were assayed by ELISA.Results. Serum cystatin C concentrations were significantly higher in obese patients compared with non-obese subjects. Decrease of body and fat mass after bariatric surgery resulted in improvement of several parameters associated with cardiovascular risk and metabolic syndrome, like serum lipids, blood pressure and insulin sensitivity. Surprisingly the mean postoperative serum cystatin C concentration was not significantly different from that before surgery. Serum creatinine and GFR also remained unchanged.Conclusion. The results presented here suggest that serum cystatin C concentration is not tightly associated with body and fat mass loss in obese patients after bariatric surgery.

Publisher

Year

Volume

84

Issue

4

Pages

202-207

Physical description

Dates

published
1 - 4 - 2012
online
14 - 6 - 2012

Contributors

  • Department of Pharmaceutical Biochemistry, Medical University in Gdańsk
  • Department of General, Endocrine and Transplant Surgery, Medical University in Gdańsk
author
  • Department of General, Endocrine and Transplant Surgery, Medical University in Gdańsk
  • Department of General, Endocrine and Transplant Surgery, Medical University in Gdańsk
  • Department of Biochemistry, Medical University in Gdańsk

References

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  • Stevens LA, Coresh J, Schmid CH et al.: Estimating GFR using serum cystatin C alone and in combination with serum creatinine: a pooled analysis of 3,418 individuals with CKD. Am J Kidney Dis 2008; 51: 395-406.[WoS]
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Document Type

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.-psjd-doi-10_2478_v10035-012-0033-0
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