Preferences help
enabled [disable] Abstract
Number of results
2010 | 82 | 4 | 212-218
Article title

Clinical Experience in Surgical Treatment of Gastrointestinal Neuroendocrine Tumors

Title variants
Languages of publication
Gastroenteropancreatic neuroendocrine tumors (GEP NET) represent heterogenous group of very rare neoplasms. Nevertheless, these tumors have been increasingly diagnosed recently. Authors present own experience with surgical treatment of gastrointestinal neuroendocrine tumors.The aim of the study was to analyse retrospectively own material of patients with gastrointestinal neuroendocrine tumors treated surgically in the Department of General and Transplant Surgery of Medical University in Łódź.Material and methods. The analysis included all patients with neuroendocrine tumors surgically treated from January 2007 to June 2009 in the Department of General and Transplant Surgery of Medical University in Łódź. The clinical patients data were obtained from medical histories, operative protocols and outcomes of final histopathological examinations. Analyzed data were as follows: age, gender, type and localization of tumor, clinical signs, results of preoperative tests and type of surgical procedure.Results. Analysis revealed that 17 patients were operated on for gastrointestinal neuroendocrine tumors between years 2007-2009 in the Department of General and Transplant Surgery. Foregut tumors (5 gastric neuroendocrine tumors and 4 pancreatic insulinomas), midgut tumors (1 neuroendocrine cancer of ascending colon, 3 hepatic neuroendocrine cancers metastases, 2 primary hepatic neuroendocrine cancers, 1 gall bladder neuroendocrine cancer) and hindgut tumors (neuroendocrine cancer of rectum) were diagnosed in nine cases (53%), in seven cases (41%) and in one case (5%), respectively. Wide range of surgeries were performed in the Department, as follows: in 2 cases right hemihepatectomy, in 3 cases extended right hemihepatectomy, in 1 case left hemihepatectomy, in 4 cases pancreatic tumor enucleation, in 2 cases gastric resection, in 3 cases gastrectomy, in 1 case right hemicolectomy and in 1 case anterior resection of the rectum. The vast majority (11/17 patients; 64%) of tumors were poorly-differentiated neuroencorine carcinomas with high grade of histological malignancy. In one case coincidence of insulinoma and nesidioblastosis was confirmed. One patient suffered from signs of neuroglycopenia with loss of consciousness and convulsion preoperatively, incorrectly diagnosed as epilepsy.Conclusions. Treatment of patients with gastrointestinal tumors is complex process and most commonly require close cooperation of various proffesional clinicians. Since asymptomatic course of disease and late stage of tumor advancement at diagnosis, technically difficult operations are often essential. Thus, surgeon who perform operations of patients with neuroendocrine tumors should be well experienced in carring out extensive surgical procedures.
Physical description
1 - 4 - 2010
15 - 9 - 2010
  • Ramage JK, Davies AHG, Ardill J et al.: Guidelines for the management of gastroanteropancreatic neuroendocrine (including carcinoid) tumours. Gut 2005, 54: 1-16.[WoS]
  • Kos-Kudła B, Bolanowski M, Handkiewicz-Junak D et al.: Zalecenia diagnostyczno-lecznicze w guzach neuroendokrynnych układu pokarmowego (rekomendowane przez Polską Sieć Guzów Neuroendokrynnych). Endokrynol Pol 2008; 1 (59): 41-56.
  • Cichocki A Chirurgiczne leczenie guzów neuroendokrynnych przewodu pokarmowego. Onkologia po dyplomie (wydanie specjalne) 2005; 42-46.
  • Rydzewska G, Cichocki A, Ćwikła J i wsp.: Guzy endokrynne żołądka i dwunastnicy z uwzględnieniem gastrinoma (zasady postępowania rekomendowane przez Polską Sieć guzów Neuroendokrynnych). Endokrynol Pol 2008; 1 (59): 57-67.
  • Kos-Kudła B, Bolanowski M, Hubalewska-Dydejczyk A i wsp.: Guzy endokrynne trzustki (zasady postępowania rekomendowane przez Polską Sieć guzów Neuroendokrynnych). Endokrynol Pol 2008; 1 (59): 68-86.
  • Bolanowski M, Jarząb B, Handkiewicz-Junak D i wsp.: Guzy neuroendokrynne jelita cienkiego i wyrostka robaczkowego (zasady postępowania rekomendowane przez Polską Sieć guzów Neuroendokrynnych). Endokrynol Pol 2008; 1 (59): 87-96.
  • Starzyńska T, Szawłowski A, Kos-Kudła B Guzy neuroendokrynne jelita grubego (zasady postępowania rekomendowane przez Polską Sieć Guzów Neuroendokrynnych). Endokrynol Pol 2008; 1 (59): 97-104.
  • Bright E, Garcea G, Ong SL et al.: An unusual case of concurrent insulinoma and nesidioblastosis. JOP 2008; 9(5):649-53.
  • O'Sullivan SS, Redmond J Response: Insulinoma presenting as refractory late-onset epilepsy. Epilepsia 2005, 46, 1690-91.
  • Graves TD, Gandhi S, Smith SJ et al.: Misdiagnosis of seizures, insulinoma presenting as adultonset seizure disorder. J Neurol Neurosurg Psych 2004; 75: 1091-92.
  • Yannakou N, Rizos S, Parissi-Mathiou P et al.: Mixed (composite) glandular-endocrine cell carcinoma of the gall-bladder. HPB 2001; 3 (1): 7-9.[Crossref]
  • Kula Z, Weishof A, Świątczak C Guzy neuroendokrynne żołądka - analiza 3 przypadków. Współczesna Onkologia 2006; 10 (2): 68-71.
  • Sutcliffe R, Maguire D, Ramage J et al.: Management of neuroendocrine liver metastases. Am J Surg 2004; 187: 39-46.
  • Carty SE, Jensen RT, Norton JA Prospective study of aggressive resection of metastatic pancreatic endocrine tumors. Surgery 1992; 112: 1024-31.[PubMed]
  • Knigge U, Hansen CP, Stadil F Interventional treatment of neuroendocrine liver metastases. Surgeon 2008; 6(4): 232-39.[Crossref][PubMed]
  • Que FG, Sarmiento JM, Nagorney DM Hepatic surgery for metastatic gastrointestinal neuroendocrine tumors. Cancer Control 2002; 9: 67-79.[PubMed]
  • Sarmiento JM et al.: Surgical treatment of neuroendocrine metastases to the liver: a plea for resection to increase survival. J Am Coll Surg 2003; 197: 29-37.
  • Olausson M et al.: Orthotopic liver or multivisceral transplantation as treatment of metastatic neuro-endocrine tumors. Liver Transpl 2007; 13: 327-33.[Crossref]
  • RehmanA, M. Pirzada T, Manzar S Neuroendocrine tumour of liver: a case reprot. Pakistan J Surg 2008; 24 (1): 71-73.
  • Donadon M, Torzilli G, Ealmisano A et al.: Liver resection for primary hepatic neuroendocrine tumours: Report of three cases and review of literature. Eur J Surg Oncol 2006; 32: 325-28.[Crossref]
  • Dala R, Shoosmith J, Lilenbaum R et al.: Primary hepatic neuroendocrine carcinoma: An underdiagnosed entity. Ann Diagn Pathol 2006; 10: 28-31.[Crossref]
Document Type
Publication order reference
YADDA identifier
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.