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2009 | 81 | 12 | 628-634
Article title

Occurrence of New Adenomas in Patients After Performed Radical Endoscopic Polypectomy

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EN
Abstracts
EN
The aim of the study was to analyze recurence of large intestine adenomas after polypectomy and its co-incidence with DNA microsatellite instability (MSI).Material and methods. Among 2880 patients who underwent polypectomy during colonoscopy in our department from June 2004 to February 2007 we revealed adenomas in 259 cases (8.99%). Then we chose 97 patients who agreed to participate in further study. Mean age of the group was 65.1 yrs. In these patiens we removed 207 adenomas of the large intestine. Within 90-360 days all of the patients underwent control colonoscopy in our department. All removed lesions were verified histologically and genetically to determine presence of microsatellite instability.Results. In 15 (17.4%) patients we revealed recurence of adenomas. Microsatellite instability was detected in 16 (18.6%) patients. The recurence of polyps was more frequent in patients with MSI (4 cases - 25%) than in patients without MSI (11 cases - 15.7%).Conclusions. In our opinion further study may help to determine the group of patients with faster adenoma recurence. In those cases more frequent colonoscopy may be justified.
Keywords
Publisher

Year
Volume
81
Issue
12
Pages
628-634
Physical description
Dates
published
1 - 12 - 2009
online
25 - 1 - 2010
Contributors
  • 2 Department of General Surgery, Collegium Medicum Jagiellonian University, Cracow
  • 2 Department of General Surgery, Collegium Medicum Jagiellonian University, Cracow
  • 2 Department of General Surgery, Collegium Medicum Jagiellonian University, Cracow
author
  • Department of Chemotherapy, University Hospital, Cracow
author
  • 2 Department of General Surgery, Collegium Medicum Jagiellonian University, Cracow
author
  • Department of Pathomorfology, Collegium Medicum Jagiellonian University, Cracow
author
  • 2 Department of General Surgery, Students' Society of Science
References
  • Lieberman DA, De Garmo PL, Fleischer DE, et al.: Patterns of endoscopy use in the United States. Gastroenterology 2000; 118(3): 619-24.
  • Rex DK: Postpolypectomy and post-cancer resection surveillance. Rev Gastroenterol Disord 2003; 3(4): 202-09.
  • Bonithon-Kopp C, Piard F, Fenger C, et al.: Colorectal adenoma characteristics as predictors of recurrence. Dis Colon Rectum 2004; 47(3): 323-33.
  • Martinez ME, Sampliner R, Marshall JR, et al.: Adenoma characteristics as risk factors for recurrence of advanced adenomas. Gastroenterology 2001; 120(5): 1077-83.
  • Noshirwani KC, van Stolk RU, Rybicki LA, et al.: Adenoma size and number are predictive of adenoma recurrence: implications for surveillance colonoscopy. Gastrointest Endosc 2000; 51(4 Pt 1): 433-37.
  • van Stolk RU, Beck GJ, Baron JA, et al.: Adenoma characteristics at first colonoscopy as predictors of adenoma recurrence and characteristics at follow-up. The Polyp Prevention Study Group. Gastroenterology 1998; 115(1): 13-18.
  • Winawer SJ, Zauber AG, O'Brien MJ, et al.: Randomized comparison of surveillance intervals after colonoscopic removal of newly diagnosed adenomatous polyps. The National Polyp Study Workgroup. N Engl J Med 1993; 328(13): 901-06.
  • Fossi S, Bazzoli F, Ricciardiello L, et al.: Incidence and recurrence rates of colorectal adenomas in first-degree asymptomatic relatives of patients with colon cancer. Am J Gastroenterol 2001; 96(5): 1601-04.
  • Winawer SJ, Zauber AG, Fletcher RH, et al.: Guidelines for Colonoscopy Surveillance After Polipectomy: A Consensus Update by the US Multi-Society Task Force on Colorectal Cancer and the American Cancer Society. Gastroenterology 2006; 130: 1872-85.
  • Atkin WS, Morson BC, Cuzick J: Long-term risk of colorectal cancer after excision of rectosigmoid adenomas. N Engl J Med 1992; 326: 658-62.
  • Umar A, Boland CR, Terdiman JP, et al.: Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability. J Natl Cancer Inst 2004; 96: 261-68.
  • Śmigiel R, Stembalska A, Stal A, et al.: The Microsatellite Instability in Patients witch Colon Cancer Treated in Lower Silesia. Adv Clin Exp Med 2006; 15: 29-36.
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.-psjd-doi-10_2478_v10035-009-0100-3
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