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2009 | 81 | 10 | 486-490

Article title

The Trefoil Peptide Family: Small But Versatile - From Anti-Apoptosis to Neoplasia in the Digestive Tract


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1 - 10 - 2009
25 - 11 - 2009


  • Division of Molecular Genetics, Institute of Human Genetics, University of Tübingen, Niemcy
  • Division of Molecular Genetics, Institute of Human Genetics, University of Tübingen, Niemcy
  • Division of Molecular Genetics, Institute of Human Genetics, University of Tübingen, Niemcy


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  • Westley B, Griffin S, May F: Interaction between TFF1, a gastric tumor suppressor trefoil protein, and TFIZ1, a brichos domain-containing protein with homology to SP-C. Biochemistry 2005; 44: 7967-75.[Crossref]
  • Clyne M, Dillon P, Daly S et al.: Helicobacter pylori interacts with the human single-domain trefoil protein TFF1. PNAS 101: 7409-14.
  • Lubka M, Shah AA, Blin N et al.: Intestinal trefoil factor (Tff3), also expressed in the inner ear, interacts with peptides contributing to apoptosis. J Appl Genet 2009; in press.[WoS]
  • Mahmood A, Melley L, Fitzgerald AJ et al.: Trial of trefoil factor 3 enemas, in combination with oral 5-aminosalicylic acid, for the treatment of mild-to-moderate left-sided ulcerative colitis. Aliment Pharmacol Ther 2005; 21: 1357-64.[Crossref][PubMed]
  • Poulsen S, Thulesen J, Christensen L et al.: Metabolism of oral trefoil factor 2 (TFF2) and the effect of oral and parenteral TFF2 on gastric and duodenal ulcer healing in the rat. Gut 1999; 45: 516-22.[Crossref]
  • Vandenbroucke K, Hans W, Van Huysse J et al.: Active delivery of trefoil factors by genetically modified Lactococcus lactis prevents and heals acute colitis in mice. Gastroenterology 2004; 127: 502-13.
  • Scholven J, Taras D, Sharbati S et al.: Intestinal expression of trefoil factors and related genes during postnatal development in a piglet probiotic trial. Cell Biochem Physiol 2009; 23: 143-56.[Crossref][WoS]

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