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Number of results
2009 | 81 | 10 | 478-485

Article title

Genetic Theory of Cancer. Short Review


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1 - 10 - 2009
25 - 11 - 2009


  • Department of Genetics, Medical University, Wrocław
  • Department of Genetics, Medical University, Wrocław


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  • Bronchud MH: Is cancer really a ‘local’ cellular clonal disease? Med Hypotheses 2002; 59(5): 560-65.[PubMed][Crossref]
  • Fabarius A, Li R, Yerganian G et al.: Specific clones of spontaneously evolving karyotypes generate individuality of cancers. Cancer Genet Cytogenet 2008; 180(2): 89-99.[WoS][Crossref][PubMed]
  • Gatenby RA, Vincent TL: An evolutionary model of carcinogenesis. Cancer Res 2003; 63(19): 6212-20.[PubMed]
  • Gil J, Stembalska A, Pesz KA et al.: Cancer stem cells: the theory and perspectives in cancer therapy. J Appl Genet 2008; 49: 193-99.[PubMed][WoS][Crossref]
  • Park M: Oncogenes in the genetic basis of human cancer, 1998, ed. Vogelstein B., Kinzler K.W., McGrew-Hill Health Professional Division.
  • Fearon EE: Tumor suppresor genes, in the genetic basis of human cancer, 1998, ed. Vogelstein B., Kinzler K.W. McGrew-Hill Health Professional Division.
  • Eshelman JR, Marcowitz SD: Microsatellite instability in inherited and sporadic neoplasms. Current Opinion in Oncol 1995; 7(1): 83-89.
  • Freisinger F, Domchek SM: Clinical implications of low-penetrance breast cancer susceptibility alleles. Curr Oncol Rep 2009; 11(1): 8-14.[PubMed][Crossref][WoS]
  • Vineis P, Manuguerra M, Kavvoura FK et al.: A field synopsis on low-penetrance variants in DNA repair genes and cancer susceptibility. J Natl Cancer Inst 2009; 101(1): 24-36.[WoS][Crossref]
  • Bignold LP: Carcinogen-induced impairment of enzymes for replicative fidelity of DNA and the initiation of tumours. Carcinogenesis 2004; 25(3): 299-307.[PubMed]
  • Shields PG, Harris CC: Cancer Risk and Low-Penetrance Susceptibility Genes in Gene-Environment interactions. J Clin Oncol 2000; 18: 2309-15.[PubMed]
  • Bignold LP: Cancer morphology, carcinogenesis and genetic instability: a background, EXS 2006; (96): 1-24.[PubMed]
  • Wogan GN, Hecht SS, Felton JS et al.: Environmental and chemical carcinogenesis. Semin Cancer Biol 2004; 14(6): 473-86.[PubMed][Crossref]
  • Grando JP, Kuasne H, Losi-Guembarovski R et al.: Association between polymorphisms in the biometabolism genes CYP1A1, GSTM1, GSTT1 and GSTP1 in bladder cancer. Clin Exp Med 2009; 9(1): 21-28.[Crossref]
  • Shen J: Evaluation of environmental and personal susceptibility characteristics that modify genetic risks. Methods Mol Biol 2009; 471: 163-77.[Crossref][PubMed]
  • Tan DS, Marchiò C, Reis-Filho JS: Hereditary breast cancer: from molecular pathology to tailored therapies. J Clin Pathol 2008; 61(10): 1073-82.[Crossref][PubMed]
  • Easton DF, Pooley KA, Dunning AM et al.: Genome-wide association study identifies novel breast cancer susceptibility loci. Nature 2007 28; 447(7148): 1087-93.
  • Turnbull C, Rahman N: Genetic predisposition to breast cancer: past, present, and future. Annu Rev Genomics. Hum Genet 2008; 9: 321-45.[Crossref][PubMed][WoS]
  • Willems PJ: Susceptibility genes in breast cancer: more is less? Clin Genet 2007; 72: 493-96.[Crossref]
  • Venkitaraman AR: Functions of BRCA1 and BRCA2 in the biological response to DNA damage. J Cell Sci 2001; 114: 3591-58.[PubMed]
  • Yee KS, Vousden KH: Complicating the complexity of p53. Carcinogenesis 2005; 26(8): 1317-22.[Crossref]
  • Plass C: Cancer epigenomics. HumMol Genet 2002; 11: 2479-88.
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  • Laird PW: The power and the promise of DNA methylation markers. Nat Rev Cancer 2003; 3: 253-66.[Crossref][PubMed]
  • Kanai Y, Hirohashi S: Alterations of DNA methylation associated with abnormalities of DNA methyltransferases in human cancers during transition from a precancerous to a malignant state. Carcinogenesis 2007; 28: 2434-42.[Crossref][WoS][PubMed]
  • Costello JF, Plass C: Methylation matters. J Med Genet 2001; 38: 285-303.[PubMed][Crossref]
  • Herceg Z: Epigenetics and cancer: towards an evaluation of the impact of environmental and dietary factors. Mutagenesis 2007; 22: 91-103.[WoS][Crossref][PubMed]
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  • Esteller M: Aberrant DNA methylation as a cancer-inducing mechanism. Annu Rev Pharmacol Toxicol 2005; 45: 629-56.[Crossref][WoS][PubMed]
  • Issa JP: CpG island methylator phenotype in cancer. Nat Rev Cancer 2004; 4: 988-93.[Crossref][PubMed]
  • Rodriguez J, Frigola J, Vendrell E et al.: Chromosomal instability correlates with genome-wide DNA demethylation in human primary colorectal cancers. Cancer Res 2006; 66: 8462-9468.[PubMed][Crossref]
  • Clark JS: Action at a distance: epigenetic silencing of large chromosomal regions in carcinogenesis. Hum Mol Genet 2007; 16: R88-R95.[Crossref][WoS]
  • Johnson CA: Chromatin modification and disease. J Med Genet 2000; 37: 905-15.[Crossref][PubMed]
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  • Frigola J, Song J, Stirzaker C et al.: Epigenetic remodeling in colorectal cancer results in coordinate gene suppression across an entire chromosome band. Nat Genet 2006; 38: 540-49.[PubMed][Crossref]
  • Karpinski P, Ramsey D, Grzebieniak Z et al.: The CpG Island Methylator Phenotype Correlates with Long-Range Epigenetic Silencing in Colorectal Cancer. Mol Cancer Res 2008; 6: 585-91.[Crossref][PubMed]
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  • Dalmay T, Edwards DR: MicroRNAs and the hallmarks of cancer. Oncogene 2006; 25: 6170-75.[Crossref][PubMed]
  • Calin GA, Croce CM: MicroRNA signatures in human cancers. Nat Rev Cancer 2006; 6: 857-66.[Crossref][PubMed]
  • Kozaki K, Imoto I, Mogi S, Omura K, Inazawa J: Exploration of Tumor-Suppressive MicroRNAs Silenced by DNA Hypermethylation in Oral Cancer. Cancer Res 2008; 68: 2094-2105.[Crossref][WoS][PubMed]
  • Fabbri M, Garzon R, Cimmino A et al.: MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B. PNAS 2007; 104: 15805-10.[Crossref]

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