This research has presented two cases of clinically silent perforation of the large intestine. The first symptoms were the following: subcutaneous emphysema of the neck, nasal speech, and extensive phlegmon of a lower limb. In both cases diagnoses were difficult and the treatment was delayed due to intestine perforation into the retroperitoneal space and lack of acute abdominal symptoms. This article explains the anatomical base of spreading infection from the retroperitoneal space to distant areas. The possibility of such uncommon complications reminds of holistic approach to every patient and thorough physical examination.