Liver Transplantation in Infants with Body Mass Less than 6 KG
Languages of publication
Liver transplantation (LTx) is the only treatment of fulminant liver failure and end stage liver disease (ESLD).The aim of the study was to assess indications, status at transplantation, surgical techniques, early and late complications and outcome of liver transplantation in children less than 6 kilograms of body weight.Material and methods. Between 1990 and 2008 in the Department of Pediatric Surgery and Organ Transplantation, Children's Memorial Health Institute, there were performed 350 LTx. Within them there were 13 (3.7%) newborn and infants with body weight below 6 kilogram. Retrospective analysis was carried out regarding indications for LTx, status at LTx, surgical techniques, early and late follow-up and outcome.Results. Follow-up of 11 living patients ranges from 5 to 111 months (mean 31.5 months). Patients and graft survival is 84.5%. In all patients liver function is very good or good. Advancement in liver surgery and perioperative care caused that LTx in small recipients became possible and are carried out with good outcome.Conclusion. Encouraging results of liver transplantation in newborn and infants caused that lower age and weight limits for liver recipients are no more significant.
1 - 2 - 2009
20 - 3 - 2009
- Karakayali H, Ozcay F, Sevmis S et al.: Liver transplantation for small babies. Transplant Proc 2007; 39(4): 1153-56.[WoS][Crossref]
- Lucianetti A, Guizzetti M, Bertani A et al.: Liver transplantation in children weighting less than 6kg: the Bergamo experience. Transplant Proc 2005; 37(2): 1143-45.
- Haberal M, Karakayali H, Arslan G et al.: Liver transplantation in children weighing less than 10 kilograms. Transplant Proc 2006; 38(10): 3585-87.[Crossref]
- Noujaim HM, Mayer DA, Buckles JA et al.: Techniques for and outcome of liver transplantation in neonates and infants weighing up to 5 kilograms. J Pediatr Surg 2002; 37(2): 159-64.[PubMed]
- Sundaram SS, Alonso EM, Whitington PF: Liver transplantation in neonates. Liver Transpl 2003; 9(8): 783-88.[Crossref]
- Tiao GM, Alonso M, Bezerra J et al.: Liver transplantation in children younger than 1 year-the Cincinnati experience. J Pediatr Surg 2005; 40(1): 268-73.[Crossref]
- Grabhorn E, Ganschow R, Helmke K et al.: Liver transplantation in infants younger than 6 months old. Transplant Proc 2002; 34(5): 1964-65.
- Saing H, Fan ST, Chan KL et al.: Liver transplantation in children: the experience of Queen Mary Hospital, Hong Kong. J Pediatr Surg 1997; 32(1): 80-83.[Crossref]
- Kelly DA: New approaches to paediatric liver transplantation. Transplant Proc 2001; 33(7-8): 3602-03.[Crossref]
- Saing H, Fan ST, Chan KL et al.: Liver transplantation in infants. J Pediatr Surg 1999; 34(11): 1721-24.[Crossref]
- Wagner C, Beebe DS, Carr RJ et al.: Living related liver transplantation in infants and children: report of anesthetic care and early postoperative morbidity and mortality. J Clin Anesth 2000; 12(6): 454-59.[PubMed][Crossref]
- Van der Werf WJ, D'Alessandro AM, Knechtle SJ et al.: Infant pediatric liver transplantation results equal those for older pediatric patients. J Pediatr Surg 1998; 33(1): 20-23.
- Strong R, Lynch S, Yamanaka J et al.: Monosegmental liver transplantation. Surgery 1995; 118(5): 904-06.[Crossref]
- Kasahara M, Uryuhara K, Kaihara S et al.: Monosegmental living donor liver transplantation. Transplant Proc 2003; 35(4): 1425-26.[Crossref]
- Ogawa K, Kasahara M, Sakamoto S et al.: Living donor liver transplantation with reduced monosegments for neonates and small infants. Transplantation 2007 27; 83(10): 1337-40.[WoS]
- Raia S, Nery JR, Mies S: Liver transplantation from live donors. Lancet 1989; 26; 2(8661): 497.
- Strong RW, Lynch SV, Ong TH et al.: Successful liver transplantation from a living donor to her son. N Engl J Med 1990 24; 322(21): 1505-07.
Publication order reference