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2008 | 80 | 11 | 604-608
Article title

Papillary Thyroid Microcarcinoma - Own Experience

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EN
Abstracts
EN
Papillary thyroid microcarcinoma is a particular form of cancer of the thyroid gland. This term, according to the WHO classification, is applied to papillary tumors no larger than 1.0 cm in diameter, which are incidentally detected during the postoperative histopathological examination. In clinical practice, the term pertains to all papillary tumors of the size smaller than or equal to 1 cm.The aim of the study was to determine the prevalence of papillary thyroid microcarcinoma and its selected histopathological characteristics among patients with malignant cancer of the thyroid gland identified in our own material in the years 2000-2007.Material and methods. The study included 523 patients treated for thyroid carcinoma: 401 (76.7%) women and 122 (23.3%) men aged 12-83 years (mean 49.8 years). Surgeries were carried out according to the Polish Group for Endocrine Carcinomas recommendations, in compliance with the European consensus.Results. Papillary thyroid carcinoma was identified in the postoperative histopathological examination in 391 (74.8%) patients; 285 (72.9%) women and 106 (27.1%) men. Their age ranged from 14 to 75 years (mean 49.3 years).Among 391 cases, tumor progression classified according to the WHO criteria (3) was as follows: T1 in 260 (66.5%), T2 in 59 (15.1%), T3 in 53 (13.5%) and T4 in 19 (4.8%) patients.In 150 cases (38.4% of papillary tumors), the tumor fulfilled the morphological criteria for microcarcinoma (4) and was detected in 118 (78.7%) women and 32 (21.3%) men. Carcinoma was identified in the neutral goiter in 138 cases, and in 12 patients in hyperactive, including 9 in nodular and 3 in Graves' goiters. The disease was suspected or diagnosed preoperatively or at surgery in 112 patients. Postoperative diagnosis was performed in 38 (25.3%) individuals with micrcarcinoma. Twenty-four (38%) of 63 patients with multifocal tumors were subjected to adjunctive surgery as their cancer diagnosis was made only postoperatively in the histopathological examination. The subcapsular location of microcarcinoma was found in 78 (49.4%) cases including capsular infiltration and extracapsular invasion in 14 patients. The exact histopathological examination showed multifocality in 63 (42%) cases and involvement of the local lymph nodes in 29 (19.3%) patients. In 21 cases, the central compartment lymph nodes were involved. The presence of metastases in the central and lateral lymph node compartment was observed in 5 cases; in 3 patients skip metastases were detected in the lateral compartment on the tumor side omitting the central compartment. No patient with microcarcinoma diagnosed between the years 2000 and 2007 revealed distant metastases.Conclusions. Due to contemporary diagnostics, papillary thyroid microcarcinomas - tumors up to 1 cm - are most commonly identified cancers of the thyroid gland. High accuracy of US-guided fine-needle aspiration biopsy of high resolution permits to diagnose the majority of these tumors prior to surgery.
Publisher

Year
Volume
80
Issue
11
Pages
604-608
Physical description
Dates
published
1 - 10 - 2008
online
4 - 5 - 2010
Contributors
author
  • Department of General and Oncological Surgery, Medical University in Łódź
  • Department of Experimental Surgery, Medical University in Łódź
  • Department of Endocrine, General and Vascular Surgery, Medical University in Łódź
References
  • Polska Grupa do spraw Nowotworów Endokrynnych. Diagnostyka i leczenie raka tarczycy. III Konferencja Naukowa - Rak Tarczycy, Szczyrk 2006.
  • Paccini F, Schlumberger M, Dralle H et al.: European consensus for menagement of patients with differentiated thyroid carcinoma of the follicular epithelium. Eur J Endocrinol 2006; 154: 787-803.
  • WHO and TNM classifiation. W: DeLellis RA, Lloyd RV Heitz Ph i wsp (red) Pathology and Genetics of Tumours of Endocrine Organs. IARC-Press Lyon 2004.
  • LiVolsi VA, Albores-Saavedra J, Asa SL et al.: Papillary carcinoma. W: DeLellis RA, Lloyd RV Heitz Ph i wsp (red) Pathology and Genetics of Tumours of Endocrine Organs. IARCPress Lyon 2004; 57-66.
  • Ottino A, Pianzola HM, Casteletto RH: Occult papillary thyroid carcinoma at autopsy in La Plata, Argentina. Cancer 1989; 64: 547-51.
  • Fransilla KO, Harach HR: Occultpapillary carcinoma of the thyroid in children and young aduldts. A systemic autopsy study in Finland. Cancer 1986; 58: 715-19.[Crossref]
  • Yeto PPB, Wang KW, Sinniach R et al.: Thyrotoxicosis and thyroid cancer. Aust NZJ Med 1982; 12: 589-93.
  • Sacco R, Aversa S, Innaro N et al.: Thyroid microcarcinoma and multinodular struma. Personal experience and considerations regarding surgical therapy. Chir Ital 2006; 58: 69-75.
  • Martinez -Tello FJ, Martinez-Cabruja R, Fernandez-Martin J et al.: Occult carcinoma of the thyroid. A systematic autopsy study from Spain of two series performed with two different methods. Cancer 1993; 71: 4022-29.
  • Bramley MD, Harrison BJ: Papillary microcarcinoma of the thyroid gland. Br J Surg 1996; 83: 1674-83.
  • Baudin E, Travagli JP, Ropers J et al.: Microcarcinoma of the thyroid gland. The Gustave-Roussy experience. Cancer 1998; 83: 553-59.
  • Corapcioglu D, Sak SD, Delibasi T et al.: Papillary microcarcinomas of the thyroid gland and immunohistohemical analysis of expression of p53 protein in papillary microcarcinomas. J Transl Med 2006; 5: 4-28.
  • Roti E, Rossi R, Transfori G et al.: Clinical and histological characteristics of papillary thyroid microcarcinoma: results of a retrospective study in 243 patients. J Clin Endocrinol Metab 2006; 91: 2171-78.
  • Jakubiak-Wielganowicz M: Analiza złośliwych nowotworów tarczycy ze szczególnym uwzględnieniem typu histologicznego raka brodawkowatego we wczesnym okresie zaawansowania [rozprawa doktorska]. Akademia Medyczna w Łodzi 2001.
  • Fardella BC, Jimenez MM, Gonzalez DH et al.: Pathological characteristics of thyroid microcarcinoma. A review of 402 biopsies. Rev Med Chil 2005; 133: 1305-10.
  • Cheema Y, Olson S, Elson D et al.: What is the biology and optimal treatment for papillary microcarcinoma of the thyroid? J Surg Res 2006; 134: 160-62.
  • Schoenberger J, Marienhagen J, Agha A et al.: Papillary microcarcinoma and papillary cancer </ = 1 cm. Modified definition of the WHO and the therapeutic dilema. Nukearmedizin 2007; 4: 115-20.
  • Machens A, Holzhausen HJ, Dralle H: Skip metastases in thyroid cancer: Leaping the central lymph node compartment. Arch Surg 2004; 139: 43-45.
  • Patchefsky AS, Keller IB, Mansfield CM: Solitary vertebral column metastasis from occult sclerosing carcinoma of the thyroid gland. Am J Clin Pathol 1970; 53: 596-601.
  • Sugitani I, Yanasigawa A, Shimizu A et al.: Clinicopathologic and immunohistohemical studies of papillary thyroid microcarcinoma presenting with cervical lymphadenopathy World J Surg 1998; 22: 731-37.
  • Kikuchi S, Noguchi S, Yamashita H et al.: Prognosis of small hyroid cancer in patients with Graves disease. Br J Surg 2006; 93: 434-39.
  • Yamashita H, Nakayama I, Noguchi S et al.: Minute carcinoma of the thyroid and its development to advanced carcinoma. Acta Pathol Jpn 1985; 35: 377-85.
  • Hay ID, Grant CS, Bergstralh EJ et al.: Papillary thyroid microcarcinoma; a study of 533 cases observed in a 50-year period. Surgery 1992; 124: 958-66.[WoS]
  • Mazzaferi E, Young RI: Papillary thyroid carcinoma: a 10 -year follow - up report of the impact of therapy in 576 patients. Am J Med 1981; 70: 511-18.
  • Noguchi S, Yamashita H, Murakami N et al.: Small carcinomas of the thyroid. Arch Surg 1996; 131: 187-91.
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.-psjd-doi-10_2478_v10035-008-0083-5
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