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2008 | 80 | 10 | 571-578
Article title

Face Transplantation: Clinical Application of the Concept

Content
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Languages of publication
EN
Abstracts
EN
The face allotransplantation is a unique procedure, requiring a lifetime immunosuppressive therapy, and as such brings an ethical debate among medical societies and general public. The indications for this procedure have to be considered when the classic reconstructive procedures failed, and the patients are left with debilitating defects precluding them from normal social life.The transplantation protocol must be approved and registered by the institutional review board and health agencies. It is crucial that a thorough assessment of the patient for each indication will be performed by a multidisciplinary team and panel of experts in the field of plastic and reconstructive surgery, maxillo facial surgery, immunology of transplantations and psychiatry. The thorough psychiatric and psychological evaluation of potential candidates is mandatory, as well as evaluation by ethic experts.Numerous experimental models and extensive anatomical studies in cadaver model lead to the clinical success of face transplantation, raising a complex ethical question despite the fact that it is an important progress in plastic and reconstructive surgery.Three face transplantations have been performed since 2005. The transplants differed and were tailored, to match the extend of each patient facial defect.In this article we present the clinical cases of face transplantation based on our experience and dissections studies and a literature review.
Publisher

Year
Volume
80
Issue
10
Pages
571-578
Physical description
Dates
published
1 - 10 - 2008
online
20 - 10 - 2008
Contributors
  • Department of Plastic Surgery, Cleveland Clinic, Cleveland, OH, USA
  • Department of Plastic Surgery, Cleveland Clinic, Cleveland, OH, USA
References
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  • Demir Y, Ozmen S, Klimczak A, et al. Tolerance induction in composite facial allograft transplantation in the rat model. Plast Reconstr Surg 2004; 114(7): 1790-1801.
  • Siemionow M, Demir Y, Mukherjee A, et al. Development and maintenance of donor-specific chimerism in semi-allogenic and fully major histocompatibility complex mismatched facial allograft transplants. Transplantation 2005; 79(5): 558-67.[Crossref]
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.-psjd-doi-10_2478_v10035-008-0079-1
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