Quality of life after pancreatoduodenectomy (PD) for cancer of the head of the pancreas depends on multiple factors. Handling of the pancreatic remnant is a decisive factor for the success of the operation. The aim of the study is to assess quality of life of patients with cancer of the head of the pancreas undergoing pylorus-sparing PD and reconstruction with pancreaticojejunostomy (PJ) versus pancreaticogastrostomy (PG).Material and methods. An analysis was performed for 115 patients with malignancy of the head of the pancreas who underwent surgical treatment in the Department of Gastrointestinal Surgery Medical Academy of Silesia between 2004 and 2006. Quality of life was assessed with the EORTC QLQ-C30 and QLQ-PAN26 forms. These questionnaires were mailed to 34 patients at least 6 months after PD. The 20 patients who returned correctly completed questionnaires were divided into two groups. Group I included 14 patients after PD with (Traverso or Imanaga) PJ. Group II included six patients after PD with Flautner PG.Results. The study groups were homogeneous with respect to age, gender, preoperative and intraoperative factors, and complications. Better quality of life was observed in group I with respect to the cognitive functions, general fatigue, and insomnia scales., Group II exhibited better quality of life with respect to the physical functioning, social functioning, life activity, general health, dyspeptic symptoms, nausea and vomiting, diarrhea, respiratory disturbances, lack of satisfaction with own appearance, taste changes, liver symptoms, decreased muscle strength, indigestion, dry mouth and treatment of emergent side-effects scales.Conclusions. Patients in the study group following PD and Flautner PG exhibit markedly better quality of life.