The study presented a thirty-three year old female patient following subtotal esophageal resection in 1989 due to caustic burn of the esophagus. The patient complained of hoarseness and dysphagia, which developed in February 2005. Following testing, the patient was diagnosed with esophageal squamous cell carcinoma with infiltration of the larynx and trachea. After oncological consultation, the patient was qualified for radiotherapy. Six months after treatment, the patient complained of dysphagia, hoarseness and shortness of breath. Endoscopy showed neoplastic infiltration of the esophagus with the presence of an esophago-tracheal fistula. The patient was qualified for surgery with esophageal and bronchial prosthesis implantation. Three months after the surgical procedure the patient died. Survival since the time of carcinoma diagnosis was nine months. The neoplastic disease developed 16 years after esophageal resection, and 25 years after its caustic burn.