Marjolin's Ulcers as a Consequence of Chronic Venous Ulcers and Chronic Skin Injury - Case Reports
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In the literature, Marjolin's ulcers are defined as skin cancers that develop secondarily in areas susceptible to an injury, seized by a chronic inflammation or covered by scar tissue.This paper presents three clinical cases of spinocellular carcinoma, which occurred around long-standing venous ulcers or chronic traumatic skin injury within the lower limbs. All the patients had their limbs amputated. No clinical or radiological qualities of lymphadenopathy were diagnosed. The latest checkups indicated the patients' good condition without traits of the neoplastic disease.Managing patients with chronic ulcers, regardless of their aetiology, requires that the doctor should have increased oncological alertness. In this case, one of the most important elements of diagnostics is a regular histopathological assessment of the lesion. Only this procedure enables the early and efficacious surgical treatment of potential secondary neoplastic lesions and possible saving of the limb.
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- Jabłońska S, Majewski S: Nowotwory złośliwe skóry. W: Jabłońska S, Majewski S: Choroby skóry i choroby przenoszone drogą płciową. Wyd. 1. PZWL, Warszawa 2005, s. 399-417.
- Baldursson B, Sigurgeirsson B, Lindelöf B: Venous leg ulcers and squamous cell carcinoma: a large-scale epidemiological study. Br J Dermatol 1995; 133: 571-74.
- Blank AA, Schnyder UW: Squamous cell carcinoma and basal cell carcinoma within the clinical picture of a chronic venous insufficiency in the third stage. Dermatologica 1990; 181: 248-50.
- Eastman AL, Erdman WA, Lindberg GM, et al.: Sentinel Lymph Node Biopsy Identifies Occult Nodal Metastases in Patients with Marjolin's Ulcer. J Burn Care Rehabil 2004; 25: 241-45.[Crossref]
- Sabin SR, Goldstein G, Rosenthal HG, et al.: Aggressive Squamous Cell Carcinoma Originating as a Marjolin's Ulcer. Dermatol Surg 2004; 30: 229-30.[Crossref]
- Baldursson BT, Beitner H, Syrjänen S: Human papillomavirus in venous ulcers with and without squamous cell carcinoma. Arch Dermatol Res 2000; 292: 275-78.
- Baldursson B, Syrjänen S, Beitner H: Expression of p21WAF1/Cip1, p53, bcl-2 and Ki-67 in Venous Leg Ulcers with and without Squamous Cell Carcinoma. Acta Derm Venereol 2000; 80: 251-55.
- Impola U, Leskanen L, Ravanti L, et al.: Expression of matrix metalloproteinase (MMP)-7 and MMP-13 and loss of MMP-19 and p16 are associated with malignant progression in chronic wounds. Br J Dermatol 2005; 152: 720-26.
- Baldursson BT, Hedblad MA, Beitner H, et al.: Squamous cell carcinoma complicating chronic venous leg ulceration: a study of the histopathology, course and survival in 25 patients. Br J Dermatol 1999; 140: 1148-52.
- Baldursson B, Sigurgeirsson B, Lindelöf B: Leg Ulcers and Squamous Cell Carcinoma, An Epidemiological Study and a Review of the Literature. Acta Derm Venereol 1993; 73: 171-74.
- Uysal A, Kocer U, Sungur N, et al.: Marjolin's ulcer on frostbite - case report. Burns 2005; 31: 792-94.[Crossref]
- Lifeso RM, Bull CA: Squamous Cell Carcinoma of the Extremities. Cancer 1985; 55: 2862-67.
- Esther R, Lamps L, Schwartz H: Marjolin Ulcers: Secondary Carcinomas In Chronic Wounds. J South Orthop Assoc 1999; 8: 181-87.
- Tan O, Atik B, Bekerecioglu, et al.: Squamous carcinoma in a pressure sore with a very short latency period. Eur J Plast Surg 2003; 26: 360-62.[Crossref]
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