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2007 | 79 | 9 | 594-599

Article title

Intraoperative Macroscopic Lung Appearance in Premature Infants with Body Weights Less than 1000 G Undergoing Surgical Treatment for PDA


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The aim of the study was to assess the relationship between intraoperatively observed macroscopic pathologic findings in the left lung and the chosen clinical factors. The factors analyzed in the study were the following: neonatal gestational age and body weight, the age of the neonate at the time of surgery, the history of intrauterine infection and/or presence of active infection in the neonate, the history of ibuprofen treatment, and intraoperative diameter of the arterial duct.Material and methods. The authors included a group of 126 preterm infants with body weight less than 1000 g undergoing surgical treatment for PDA in the 2nd Department of Cardiac and General Pediatric Surgery between January 2000 and May 2006 and analyzed the macroscopic intraoperative left lung appearance.The average body weight of the neonates who participated in the study was 765.2 g, with the average gestational age 25.68 Hbd. According to the results of intraoperative macroscopic lung assessment, the neonates were classified into one of the following three groups:0 - normal lungs or partially stiff lungs with emphysema focuses,1 - limited macroscopic findings, focuses of limited atelectasis, lung congestion,2 - severe pathologic findings in the pulmonary tissue, pulmonary hematomas, bleeding pulmonary surface, disseminated atelectasis, liver-like pulmonary tissue.In the study, the statistical analysis of the relationship between pathological pulmonary findings (groups 0, 1, 2) and investigated factors was performed by the comparison of mean values (or median) of the investigated factor in the analyzed groups. The Kruskal-Wallis and the Mann-Whitney tests were used dependent of the analyzed factor. Additionally, for chosen factors (the infection presence and PDA diameter), their relationship with the lung macroscopic appearance was assessed with the use of the Spearman test.Results. The pathological findings in the lungs were observed in the majority of the neonates (54%). The statistical analysis did not show any relationship between the pulmonary disorders and the majority of investigated factors.Conclusions. 1. The authors found that a duct diameter of ≥ 4 mm correlates with the development of more severe disorders in the pulmonary tissue. 2. The authors emphasized the good results of surgical treatment of PDA and the lack of death in the perioperative period in that group of patients.


PDA   ELBW   thoracotomy   lungs  








Physical description


1 - 9 - 2007
11 - 2 - 2008


  • 2nd Department of Cardiac and General Pediatric Surgery, Medical University, Warsaw
  • 2nd Department of Cardiac and General Pediatric Surgery, Medical University, Warsaw


  • Van Overmeire B, Smets K, Lecoutere D et al.: A comparison of ibuprofen and indomethacin for closure of patent ductus arteriosus. N Engl J Med 2000; 343: 674-81.
  • Pokharel R, Hisano K Yasofuku et al.: Ligation of medically refracted patent ductus arteriosus in an extremely low body weight premature infant; Surgery Today 1998; 1291-93.
  • Knight DB: Patent ductus arteriosus: how important to which babies. Early Develop 1992; 29: 287-92.
  • Evans N, Lyer P: Longitudinal changes in the diameter of the ductus arteriosus in the ventilated preterm infants: correlation with respiratory outcomes. Arc Dis Child 1995; 72: F156-F161.
  • Wyllie J: Treatment of patent ductus arteriosus. Seminars in Neonatology 2003; 8: 425-32.
  • Evans N: Patent ductus arteriosus in the neonate. Current paediatrics 2005; 15: 381-89.
  • Knight DB: The treatment of patent ducutus arteriosus in preterm. A review and overview of randomised trials. Semin Neonatol 2001; 6: 63-73.
  • Stefano JL et al.: Closure of the ductus arteriosus with indomethacin in ventilated neonates with respiratory distress syndrom. Effects of pulmonary compliance and ventilation. An Rev Resp Dis 1991; 143: 236-39.
  • Brown ER: Increased risk of bronchopulmonary dysplasia in infants with patent ductus arteriosus. J Pediatr 1979; 95: 865-66.[PubMed]
  • Kluckov M, Evans N: Early echokardiographic prediction of symptomatic patent ductus arteriosus in preterm infanst undergoing mechanical ventilation. J Pediatr 1995; 127(5): 774-79.
  • Pezzati M, Vangi V, Biagiotti R et al.: Effects of indomethacin and ibuproffen on mesenteric and renal blood flow in preterm infansts with patent ductus arteriosus. J Pediatr 1999; 135: 733-38.
  • Van Overmeire B, Vanhaesebrouck P, Langhendries JP: Early versus late selective treatment of patent ductus arteriosus in preterm infants with respiratory distress syndrome Ped Res 1998; 43(suppl 2): 200.
  • Gersony WM, Peckham GJ, Ellison RC et al.: Effects of indomethacin in premature infants with patent ductus arteriosus: results of national collaborative study. J Pediatr 1983; 102: 895-906.[PubMed]
  • Jaillard S, Larrue B, Rakza T et al.: Consequences of delayed surgical closure of patent ductus arteriosus in very premature infants. Ann Thorac Surg 2006; 81: 231-35.[PubMed]
  • Trus T, Winthrop AL, Pipe S et al.: Optimal management of patent ductus arteriosus in the neonate weighing less than 800 g. J Pediatr Surg 1993; 28: 1137-39.
  • Cassady G, Crouse DT, Kirklin JW et al. A randomized controlled trial of very early prophylactic ligation of the ductus arteriosus in babies who weighed 1000 g or less at birth. N Engl J Med 1989; 320: 1511-16.
  • Karolczak MA, Bęc L: Wyniki chirurgicznego zamknięcia przetrwałego przewodu tętniczego u noworodków z masą ciała poniżej 1000 g. Pediatria Pol 2001; 11: 483-86.
  • Coster DD, Gorton ME, Grooters RK et al. Surgical closure of the patent ductus arteriosus in the neonatal intensive care unit. Ann Thorac Surg 1989; 48: 386-89.[PubMed]
  • Little DC, Pratt TC, Blalock SE et al.: Patent ductus arteriosus in micropreemies and full term infanst: The relative merits of surgical ligation versus indomethacin treatment. J Pediatr Surg 2003; 38(3): 492-96.[PubMed][Crossref]
  • Krauss An, Fatica N, Lewis BS et al.: Pulmonary function in preterm infants following treatment with intravenous indomethacin. Am J Dis Child 1989; 143: 78-81.
  • Yeh TF, Thalji A, Luken L et al.: Improved lung compliance following indomethacin therapy in premature infants with persistent ductus arteriosus. Chest 1981; 80: 698-700.[PubMed]
  • Gerhardt T, Bancalari E: Lung compliance in newborns with patent ductus arteriosus before and after surgical ligation. Biol Neonate 1980; 96: 96-105.[PubMed]
  • Naulty CM, Horn S, Conry J et al.: Improved lung compliance after ligation of patent ductus arteriosus in hyaline membrane disease. J Pediatr 1978; 93: 683-84.

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