The aim of the study was to evaluate whether serum lipid concentrations [total cholesterol (TC), HDL cholesterol (HDL), LDL cholesterol (LDL), triglycerides (TG)] vary between patients with lower extremity claudication depending on the location of pathologic arterial changes above and below the inguinal ligament.Material and methods. Our investigation included 24 patients with changes in the aorto-iliac and 15 in the femoro-popliteal segment, in whom advanced ischaemia reached IIb and III according to Fontaine's scale. The results obtained from our patients were compared to non-claudicant controls, who were matched to the claudification patients with respect to age, body mass index, smoking and concomitant illnesses.Results. Every fourth patient with claudication demonstrated correct results of the four mentioned lipidogram components. The percentage of incorrect results was higher in patients with changes in the aorto-iliac segment relative to patients with changes in the femoro-popliteal segment and amounted to 63% vs 20% for HDL, and 63% vs 13% for TG, respectively. TG concentration and TC/HDL and LDL/HDL ratios vary between the two groups of patients. TC/HDL and LDL/HDL ratios are significantly higher in patients with aorto-iliac segment changes as compared to the control group, but do not vary when compared to arteries below the inguinal ligament. The level of TC, HDL and LDL is higher in the control group as compared to the median results for all examined patients.Conclusions. Patients with lower limb claudication following pathology of the aorto-iliac and femoropopliteal segments do not constitute a homologous group; therefore, further extensive research is necessary to explain this phenomenon.