Full-text resources of PSJD and other databases are now available in the new Library of Science.
Visit https://bibliotekanauki.pl


Preferences help
enabled [disable] Abstract
Number of results
2007 | 79 | 3 | 196-208

Article title

The Efficacy of Various Management Options for Malignant Pleural Effusions


Title variants

Languages of publication



Malignant pleural effusion (MPE) may be the first manifestation of the neoplastic disease or its complication.The aim of the study was determining the most effective management, comparison of the efficacy of various therapeutic options, evaluation of treatment results.Material and methods. Between 1996 and 2003, 150 patients were treated in the Wrocław Thoracic Surgery Centre. Lung cancer was diagnosed in 61 (40.7%), other malignancy in 82 (54.7%), primary focus was not established in 7 (4.7%) patients. There were following groups. Group I (n=39): patients who underwent pleurodesis with Bleomycin (60 mg), group II (n=36) - Doxycylin (1 g or 0,5 g), group III (n=52) - Talc (4 g), group IV (n=12) - politherapy, group V (n=11) - other patients.Results. Patients from group I - IV were undergone statistical analysis. This group was divided into subgroup A (n=24, patients who died within first month) and subgroup B (n=115, who lived longer). In subgroup A total remission was achieved in I - 100%, in II - 70%, in III - 100%. The worst results were obtained in group II, but there weren't SSD between groups (p>0,05). In subgroup B total remission was analyzed after 1, 3, 6, 9 months. Total remission after 9 months was achieved in I - 85,2%, in II - 69,2%, in III - 98%, in IV - 91,7%. SSD occurred between groups I and III (p=0,0327), II and III (p<0.001). Median mean rate survival was in I - 239, in II - 232, in III - 267, in IV - 207 days (p>0,05). Drainage complications and signs effect were analyzed.Conclusions. The best results were achieved after using Talc. In instance of difficulties of inhibition MPE we should apply politherapy. There weren't SSD in survival length between groups. The most common signs effect was pain, which occurred more frequent after instillation of Doxycyline and Talc than Bleomycin and fever which occurred the most frequent after instillation Talc and after politherapy








Physical description


1 - 3 - 2007
24 - 9 - 2007


  • Department of Thoracic Surgery, Medical University, Wrocław
  • Department of Thoracic Surgery, Medical University, Wrocław


  • Kacprzak G, Kołodziej J, Rzechonek A et al.: Management of malignant pleural effusion. W: Second International Congress of Thorax Surgery. June 24-26, 1998; Bologna, Italy. Editrice Compositori 1998; 325-30.
  • Taubert J: Management of malignant pleural effusion. Nurs Clin North Am 2001; 36(4): 665-83.[PubMed]
  • Lynch TJ: Management of Malignant Pleural Effusions. Chest 1993; 103(4): 385-89.
  • Ruckdeschel J. Management of malignant pleural effusion: an overview. Semin Oncol 1988; 15: 24-28.
  • American Thoracic Society. Management of Malignant Pleural Effusions. Am J Respir Crit Care Med 2000; 162: 1987-2001.
  • Antony VB, Loddenkemper R, Astoul P et al.: Management of malignant pleural effusions. Eur Respir J 2001; 18: 402-19.[Crossref]
  • Ruckdeschel JC, Moores D, Lee JY et al.: Intrapleural therapy for malignant pleural effusion. A randomized comparison of Bleomycin and Tetracycline. Chest 1991; 100(6): 1528-35.[Crossref][PubMed]
  • Schulze M, Boehle AS, Kurdow R et al.: D. Effective Treatment of Malignant Pleural Effusion by Minimal Invasive Thoracic Surgery: Thoracoscopic Talc Pleurodesis and Pleuroperitoneal Shunts in 101 Patients. Ann Thorac Surg 2001; 71: 1809-12.
  • Anderson CB, Philpott GW, Ferguson TB: The treatment of malignant pleural effusions. Cancer 1974; 33: 916-22.
  • Putnam JB, Light RW, Rodriguez RM et al.: A randomized comparison of indwelling pleural catheter and doxycycline pleurodesis in the management of malignant pleural effusions. Cancer 1999; 86: 1992-99.
  • Zaloznik AJ, Oswald SG, Langin M: Intrapleural Tetracycline in Malignant Pleural Effusions. A randomized study. Cancer 1983; 51: 752-55.
  • Morrison MC, Mueller PR, Lee MJ et al.: Sclerotherapy of malignant pleural effusion through sonographically placed small-bore catheters. A J R 1992; 158(1): 41-43.
  • Gust R, Kleine P, Fabel H: Fibrin glue and tetracycline pleurodesis in reccuring malignant pleural effusion - A randomized comparative study. Medizinische Klinik 1990; 85(1): 18-23.
  • Landvater L, Hix WR, Mills M et al.: Malignant Pleural Effusion Treated by Tetracycline Sclerotherapy. A Comparison of Single vs Repated Instillation. Chest 1988; 93(6): 1196-98.
  • Sugita T, Matsunaga K, Kobayashi H et al.: Intrapleural bleomycin for management of malignant pleural effusions. Gan To Kagaku Ryoho. 1995; 22(9): 1203-07.
  • Ong KC, Indumathi V, Raghuram J et al.: A comparative study of pleurodesis using talc and bleomycin in the management of malignant pleural effusions. Respirology 2000; 5: 99-103.[Crossref]
  • Martinez-Moragon E, Aparicio J, Rogado MC et al.: Pleurodesis in malignant pleural effusions: a randomized study of tetracycline versus bleomycin. Eur Respir J 1997; 10(10): 2380-83.[Crossref]
  • Patz EF, McAdams HP, Erasmus JJ et al.: Sclerotherapy for malignant pleural effusions. A prospective randomized trial of Bleomycin vs Doxycycline with small-bore catheter drainage. Chest 1998; 113(5): 1305-11.
  • Cardillo G, Facciolo F, Carbone L et al.: Long-term follow-up of video-assisted talc pleurodesis in malignant recurrrent pleural effusions. Eur J Cardiothorac Surg 2002; 21: 302-06.
  • Milanez JRC, Vargas FS, Werebe EC et al.: Thoracoscopy Talc Poudrage. A 15-Year Experience. Chest 2001; 119: 801-06.
  • Emad A, Rezaian GR: Treatment of Malignant Pleural Effusions with a Combination of Bleomycin and Tetracycline. A comparison of Bleomycin or Tetracycline Alone versus a Combination of Bleomycin and Tetracycline. Cancer 1996; 78(12): 2498-2501.
  • Vidyasagar MS, Ramanujam AS, Fernandes DJ et al.: Vincristine (Vinca-Alkaloid) as a Sclerosing Agent for Malignant Pleural Effusions. Acta Oncologica 1999; 38(8): 1017-20.
  • Gilkeson RC, Silverman P, Haaga JR: Using Urokinase to Treatment Malignant Pleural Effusions. A J R 1999; 173: 781-83.
  • Tohda Y, Iwanaga T, Takada M et al.: Intrapleural Administration of Cisplatin and Etoposide to Treat Malignant Pleural Effusions in Patients with Non-Small Cell Lung Cancer. Chemotherapy 1999; 45: 197-204.
  • Pien GW, Gant MJ, Washam CL et al.: DH. Use of an Implantable Pleural Catheter for Trapped Lung Syndrome in Patients with Malignant Pleural Effusion. Chest 2001; 119(6): 1641-46.

Document Type

Publication order reference


YADDA identifier

JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.