Hereditary Nonpolyposis Colorectal Cancer in Lower Silesia
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The aim of the study was to assess the frequency of hereditary nonpolyposus colorectal cancer in the Lower Silesia area.Material and methods. The study population consists of 318 patients hospitalized between 2001-2002 on 14 surgical wards in the Lower Silesia area. Patients formed four groups: hereditary nonpolyposis colorectal cancer (HNPCC), suspected HNPCC (S-HNPCC), familial colorectal cancer (FCC) and cancer familial aggregation (CFA). The epidemiological data were analyzed (age on onset, gender, localization, extracolonic tumors in family).Results. 3.77% of all patients with colorectal cancer (CRC) were diagnosed with HNPCC and 6.92% with S-HNPCC. The mean age of CRC onset in HNPCC group was 53.07; in the S-HNPCC group, 62.2. Seven male and 5 female patients were diagnosed with HNPCC; for S-HNPCC, 14 males and 8 females were diagnosed. In the HNPCC group, 55.55% of CRC were situated in the right colon and in 44.55%, the left colon. In the S-HNPCC group, 28.57% CRC was in the right colon and in 71.43%, the left colon. In the HNPCC and S-HNPCC groups, there were 4 patients diagnosed with synchronous sigmoid and rectal adenomas. Two of them were diagnosed during intraoperative colonoscopy. One patient was diagnosed with 3 metachronous lesions. In the families of 6 patients with HNPCC extracolonic tumors were identified.Conclusions. 1. Knowledge of HNPCC criteria ensures proper treatment of the patient and their family. 2. During colonoscopy, the whole colon should be inspected. 3. Patients suspected of HNPCC should undergo intraoperative colonoscopy.
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24 - 9 - 2007
- Lovett E: Family studies in cancer of the colon and rectum. Br Surg 1976; 63: 13-18.[Crossref]
- Ponz de Leon M, Sassatelli R, Sacchetti C et al.: Familial aggregation of tumors in the three-year experience of a population-based colorectal cancer registry. Cancer Res 1989; 49(15): 4344-48.
- Lynch HT, Watson P, Shaw TG et al.: Clinical impact of molecular genetic diagnosis, genetic counseling, and management of hereditary cancer. Part II: Hereditary nonpolyposis colorectal carcinoma as a model. Cancer 1999; 86(11 Suppl): 2457-63.[WoS]
- Aaltonen LA, Salovaara R, Kristo P et al.: Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease. N Engl J Med 1998; 338(21): 1481-87.
- Pawlak A, Drews M: Genetycznie uwarunkowana podatność na raka jelita grubego. I. Silne dziedziczne predyspozycje do rozwoju raka jelita grubego. Pol Przegl Chir 1997; 69: 1228-34.
- Knudson AG: Hereditary cancer: two hits revisited. J Cancer Res Clin Oncol 1996; 122(3): 135-40.
- Fishel R, Lescoe MK, Rao MR et al.: The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer. Cell 1994; 77(1): 167.
- Vasen HFA, Watson P, Mecklin JP et al.: New Clinical Criteria for Hereditary Nonpolyposis Colorectal Cancer (HNPCC, Lynch syndrome) Proposed by the International Collaborative Group on HNPCC. Gastroenterology 1999; 116: 1453-56.
- Rodriques-Bigas MA, Boland CR, Hamilton SR et al.: A National Cancer Institute Workshop on Hereditary Nonpolyposis Colorectal Cancer Syndrome: meeting highlights and Bethesda Guidelines. J Nat Cancer 1997; 89: 1758-62.
- Park JG, Vasen FA, Park KJ et al.: Suspected Hereditary Nonpolyposis Colorectal Cancer. Dis Colon Rectum 1999; 42: 710-16.
- Park JG, Vasen FA, Park KJ et al.: Suspected HNPCC and Amsterdam criteria II: evaluation of mutation detection rate, an international collaborative study. Int J Colorectal Dis 2002; 17: 109-14.[PubMed][Crossref]
- Kladny J, Möslein G, Myrhøj T et al.: Nuclear pedigree criteria of suspected HNPCC. Hereditary Cancer in Clinical Practice 2003; 1: 34-38.
- Błaszczyk J, Pudełko M, Cisarż K: Nowotwory złośliwe w woj. dolnośląskim w roku 2002. Dolnośląski Rejestr Nowotworów. Dolnośląskie Centrum Onkologii 2002.
- Kunitomo K, Terashima Y, Sasaki K et al.: HNPCC In Japan. Anticancer Res 1992; 12: 1856.
- Mecklin JP: Frequency of hereditary colorectal carcinoma. Gastroenterology 1987; 93: 1021-25.
- Jass JR, Steward SM: Evolution of hereditary non-polyposis colorectal cancer. Gut 1992; 33: 783-86.[PubMed][Crossref]
- Vasen HF, Taal BG, Griffioen G et al.: Clinical heterogeneity of familial colorectal cancer and its influence on screening protocols. Gut 1994; 35(9): 1262-66.
- Vasen HF, Nagengast FM, Khan PM: Interval cancers in hereditary non-polyposis colorectal cancer (Lynch syndrome) Lancet 1995; 345(8958): 1183-84.
- Jarvinen HJ, Aarnio M, Mustonen H et al.: Controlled 15-year trial on screening for colorectal cancer in families with hereditary nonpolyposis colorectal cancer. Gastroenterology 2000; 118(5): 829-34.
- Fitzgibbons RF, Lynch HT, Stanislav GV et al.: Recognition and Treatment of Patients with Heridetery Non Polyposis Colon Cancer (Lynch Syndromes I and II): Ann Surg 1987; 206(3): 289-95.
- Percesepe A, Anti M, Marra G et al.: Role of clinical criteria in the diagnosis of hereditary non-polyposis colorectal cancer (HNPCC): results of a multivariate analysis. Int J Cancer 1994; 58(6): 799-802.
- De Jong AE i wsp: Decrease in mortality in Lynch syndrome families because of surveillance. Gastroenterology 2006; 130(3): 665-71.
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