Development of a method of exposed characteristic points in activity pattern for rat behaviour classification

• Authors: Kamil Stefko , Tomasz Bukowski , Michał Urbański
• Languages of publication: EN

Abstracts

EN

A fast method for visual inspection and classification of massive locomotor activity data registered from laboratory rats is presented. Positions in the home cage of one hundred rats have been constantly recorded during 90 day period using photodiodes and beam crossing method with use of custom build system. Direct inspection and comparison of classic form of actograms did not bring information for fast and easy recognition of anomalies in daily behavioural cycle. A method of obtaining fast and easy to compare locomotor activity pattern is presented. The key point of proposed method is exposition of characteristic points in the activity diagram. About 9000 actograms were inspected and classified for investigation with use of ANOVA.

Keywords

EN

Keywords preclinical test; locomotor activity; actogram; behaviour recognition; rats

• Publisher: Versita
• Journal: Polish Journal of Medical Physics And Engineering
• Year: 2012
• Volume: 18
• Issue: 1
• Pages: 23-28

Dates

published

1 - 03 - 2012

online

26 - 02 - 2013

Contributors

author

Kamil Stefko

• Institute of Metrology and Biomedical Engineering, Warsaw University of Technology, Św. A. Boboli 8, 02-525 Warsaw, Poland

author

Tomasz Bukowski

• NASK (Research and Academic Computer Network), Wąwozowa 18, 02-796 Warsaw, Poland

author

Michał Urbański

• Faculty of Physics, Warsaw University of Technology, Koszykowa 75, 00-662 Warsaw, Poland

References

• [1] Babbini M, Davis WM. Time-dose relationships for locomotor activity effects of morphine after acute or repeated treatment. Br J Pharmacol.1972;46:213-24
• [2] Dunne F, O'Halloran A, Kelly JP. Development of a home cage locomotor tracking system capable of detecting the stimulant and sedative properties of drugs in rats. Prog in Neuro-Psychopharmacol and Biol Psychiatry. 2007 October 1;31(7):1456-1463
• [3] Galani R, Duconseille E, Bildstein O, Cassel J-C. Effects of room and cage familiarity on locomotor activity measures in rats. Physiol & Behav. 2001 September;74(1-2, 1-15):1-4
• [4] Joyce EM, Iversen SD. Dissociable effects of 6-OHDA-induced lesions of neostriatum on anorexia, locomotor activity and stereotypy: the role of behavioural competition. Psychopharmacol. 1984;83:363-66[PubMed]
• [5] Komater VA, Browman KE, Curzon P, Hancock AA, Decker MW, Fox GB. H3 receptor blockade by thioperamide enhances cognition in rats without inducing locomotor sensitization. Psychopharmacol. 2003 June;167(4):363-372
• [6] Sabeti J, Gerhardt GA, Zahniser NR. Individual differences in cocaine-induced locomotor sensitization in low and high cocaine locomotor-responding rats are associated with differential inhibition of dopamine clearance in nucleus accumbens. J Pharmacol Exp Ther. 2003;305:180-90
• [7] Tang X, Sanford LD. Home cage activity and activity-based measures of anxiety in 129P3/J, 129X1/SvJ and C57BL/6J mice. Physiol & Behav. 2005 January 31;84(1)105-115
• [8] Truong L, Allbutt H, Kassiou M, Henderson JM. Developing a preclinical model of Parkinson's disease: A study of behaviour in rats with graded 6-OHDA lesions. Behav Brain Res. 2006 April 25;169(1):1-9
• [9] Whishaw IQ, Kolb B, editors. The Behavior of the Laboratory Rat. New York:Oxford University Press;c2005. Chapter 17,Circadian Rythms; p.183-94

Identifiers

DOI

10.2478/v10013-012-0004-0