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Number of results
2010 | 16 | 2 | 85-95

Article title

Study of dosimetric variation due to interfraction organ movement in High Dose Rate Interstital (MUPIT) brachytherapy for gynecologic malignancies

Content

Title variants

Languages of publication

EN

Abstracts

EN
Ten patients with cancer of uterine cervix who underwent interstitial brachytherapy using MUPIT templates were CT scanned (CT1) using which bladder, rectum and CTV were delineated. The treatment plan PCT1 was generated and optimized geometrically on the volume. CT scan (CT2) was repeated before the second fraction of the treatment CTV and critical organs were delineated. The plan (PCT2) was created by reproducing the Plan PCT1 in the CT2 images and compared with PCT1. Bladder, Rectum and CTV percentage volume variation ranges from +28.6% to -34.3%, 38.4% to -14.9% and 8.5% to -15.2% respectively. Maximum dose variation in bladder was +17.1%, in rectum was up to +410% and in CTV was -13.0%. The dose to these structures varies independently with no strong correlation with the volume variation. Hence it is suggested that repeat CT and re-planning is mandatory before second fraction execution.

Publisher

Year

Volume

16

Issue

2

Pages

85-95

Physical description

Dates

published
1 - 1 - 2010
online
5 - 5 - 2011

Contributors

  • Medical Physics Department, Cancer Institute, Adyar, Chennai 600 036, Tamil Nadu, India
  • Medical Physics Department, Comprehensive Blood & Cancer Centres Apollo Hospitals
  • Medical Physics Department, Cancer Institute, Adyar, Chennai 600 036, Tamil Nadu, India

References

  • Gaddis O, Morrow CP, Klement V et al. Treatment of cervical carcinoma employing a template for transperineal interstitial Ir192 brachytherapy. Int J Radiat Oncol Biol Phys. 1983;9:819-827.[Crossref]
  • Ampuero F, Doss LL, Khan M et al. The Syed-Neblett interstitial template in locally advanced gynecological malignancies. Int J Radiat Oncol Biol Phys. 1983;9:1897-1903.[PubMed][Crossref]
  • Aristizabal SA, Surwit EA, Hevezi JM et al. Treatment of advanced cancer of the cervix with transperineal interstitial irradiation. Int J Radiat Oncol Biol Phys. 1983;9:1013-1017.[Crossref][PubMed]
  • Martinez A, Cox RS, Edmunson GK. A multiple-site perineal applicator (MUPIT) for treatment of prostatic, anorectal, and gynecological malignancies. Int J Radiat Oncol Biol Phys. 1984;10:297-305.[Crossref]
  • Martinez A, Edmunson GK, Cox RS et al. Combination of external beam irradiation and multiplesite perineal applicator (MUPIT) for treatment of locally advanced or recurrent prostatic, anorectal, and gynecologic malignancies. Int J Radiat Oncol Biol Phys. 1985;11:391-398.[Crossref]
  • Syed AMN, Puthawala AA, Neblett D. Transperineal interstitial-intracavitary Syed-Neblett applicator in the treatment of carcinoma of the uterine cervix. Endocurie Hypertherm Oncol. 1986;2:1-13.
  • Monk BJ, Tewari K, Burger RA, et al. A comparison of intracavitary versus interstitial irradiation in the treatment of cervical cancer. Gynecol Oncol 1997; 67: 241-247.[Crossref][PubMed]
  • Nag S, Martinez-Monge R, Ellis R. The use of fluoroscopy to guide needle placement in interstitial gynecological brachytherapy. Int J Radiat Oncol Biol Phys. 1998;40:415-420.[PubMed][Crossref]
  • Gupta AK, Vicini FA, Frazier AJ. Iridium-192 transperineal interstitial brachytherapy for locally advanced or recurrent gynecological malignancies. Int J Radiat Oncol Biol Phys. 1999;43:1055-1060.[PubMed][Crossref][WoS]
  • Demanes DJ, Rodriguez RR, Bendre DD, Ewing TL. High dose rate transperineal interstitial brachytherapy for cervical cancer: High pelvic control and low complication rates. Int J Radiat Oncol Biol Phys. 1999;45:105-112.[PubMed][Crossref]
  • Nag S, Erickson B, Thomadsen B. The American Brachytherapy Society recommendations for high-dose-rate brachytherapy for carcinoma of the cervix. Int J Radiat Oncol Biol Phys. 2000;48:201-211.[Crossref]
  • Sitathanee C, Pairatchvet V, Narkwong L et al. High-dose-rate interstitial brachytherapy in the management of carcinoma of the uterine cervix and other gynecologic malignancies. J Med Assoc Thai. 2005;88:1045-1050.[PubMed]
  • Jamema SV, Saju S, Shetty UM et al. Dosimetric comparison of inverse optimization with geometric optimization in combination with graphical optimization for HDR prostate implants. J Med Phys. 2006;31:89-94.[PubMed][Crossref]

Document Type

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.-psjd-doi-10_2478_v10013-010-0008-6
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