Spin traps in the detection of free radicals in the blood of patients with ischemia

• Authors: Ryszard Krzyminiewski , Zdzislaw Kruczynski , Aleksander Stepien , Bernadeta Dobosz
• Languages of publication: EN

Abstracts

EN

Electron Paramagnetic Resonance and a nitrosobenzene spin trap were used to investigate free radicals in the human blood after angioplasty treatment. The nitrosobenzene anion radical was determined using EPR measurements and quantum-mechanical calculations. Differences were observed in the concentration of free radicals before and after angioplasty treatment. These results were compared with myocardium damage parameters (CPK, MB and TnT).

Keywords

EN

Electron Paramagnetic Resonance; nitrosobenzene spin trap; angioplasty treatment; free radicals

• Publisher: Versita
• Journal: Polish Journal of Medical Physics And Engineering
• Year: 2009
• Volume: 15
• Issue: 1
• Pages: 47-54

Dates

published

1 - 1 - 2009

online

22 - 9 - 2010

Contributors

author

Ryszard Krzyminiewski

• Faculty of Physics/Medical Physics Division, Adam Mickiewicz University, Poznan, Poland

author

Zdzislaw Kruczynski

• Faculty of Physics/Medical Physics Division, Adam Mickiewicz University, Poznan, Poland

author

Aleksander Stepien

• Regional Hospital, Kielce, Poland

author

Bernadeta Dobosz

• Faculty of Physics/Medical Physics Division, Adam Mickiewicz University, Poznan, Poland

References

• Bergendi L, Benes L, Durakova Z, Ferenik M. Chemistry, Physiology and Pathology of free radicals. Life Sci. 1999; 65(18/19): 1865-1874.
• Jacobson MD. Reactive oxygen species and programmed cell death. Trends Biochem Sci. 1996; 21(3): 83-86.[PubMed]
• Kerr MF, Bender CM, Monti EJ. An introduction to oxygen free radicals. Heart Lung. 1996; 25(3): 200-209.[PubMed][Crossref]
• Lefer DJ, Granger DN. Physiology in Medicine. Oxidative Stress and Cardiac Disease. Am J Med. 2000; 109: 315-323.
• Liuzzo G, Buffon A, Biasucci LM, Gallimore JR, Caligiuri G, Vitelli A, Altamura S, Ciliberto G, Rebuzzi AG, Crea F, Pepys MB, Maseri A. Enhanced Inflammatory Response to Coronary Angioplasty in Patients With Sever Unstable Angina. Circ J Am Heart Assoc. 1998; 98: 2370-2376.
• Mair J, Artner-Dworzak E, Leichleitner P, Smidt J, Wagner I, Dienstl F, Puschendorf B. Cardiac Troponin T in Diagnosis of Acute Myocardial Infarction. Clin Chem. 1991; 37(6): 845-852.[PubMed]
• Milam SB, Zardeneta G, Schmitz JP. Oxidative Stress and Degenerative Temporomandibular Joint Disease: A Proposed Hypothesis. J Oral Maxillofac Surg. 1998; 56: 214-223.[PubMed]
• Mimic-Oka J, Simic DV, Simic TP. Free Radicals in Cardiovascular Diseases. The scientific journal FACTA UNIVERSITATIS. Med Biol. 1999; 6(1): 11-22.
• Stepien E, Sniezek-Maciejewska M, Szajna-Zych M, Sadowski J. Biochemical markers in diagnostics of perioperative cardiac injury. Cardiol Forum. 2002; 7(4): 135-142.
• Zweier JL, Flaherty JT, Weisfeldt ML. Direct measurement of free radical generation following reperfusion of ischemic myocardium. The Proceedings of the National Academy of Sciences. 1987; 84: 1404-1407.
• Zweier JL, Kuppusamy P, Williams R, Rayburn BK, Smith D, Weisfeldt ML, Flaherty JT. Measurement and Characterization of Postischemic Free Radical Generation in the Isolated Perfused Heart. J Biol Chem. 1989; 264(32): 18890-18895.

Identifiers

DOI

10.2478/v10013-009-0005-9