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2014 | 9 | 6 | 860-865

Article title

The hemiface transplant in rodent model


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The composite allotransplant of tissues was recently introduced on the list of potential procedures for complex face reconstruction. To assess the technical and immunological aspects and the potential of the clinical applicability of this new approach in facial reconstruction, samples of total and hemifacial transplant with rats have been introduced. We have proposed in this study checking the versatility of the facial transplant sample in rats by performing the hemiface transplant between two neco-blood species of laboratory rats. Meanwhile, study included the verification of mono-therapy efficiency with A cyclosporine in inducing immune tolerance against the composite tissue graft, which consists of skin, subcutaneous tissue, blood vessels and ear cartilage, transferred against the hystocompatibility barriers, as well as the verification of the procedures adjacent to transplant: anesthesia and surgical technique. In this study,14 laboratory rats have been included and divided into 3 lots. Lot No. 1 was represented by 2 Brown Norway rats used for the anatomic study of the vascular formations which are going to be coopted during a facial transplant. Lot No. 2 consisted of 3 Brown Norway rats used as donors and 3 Wistar rats used as acceptors, with these transplants being associated immunosuppression protocols postop. Llot No. 3 consisted of 3 Brown Norway rats used as donors and 3 Wistar rats used as acceptors, which, after the intervention, did not receive an immunosuppression treatment. Conclusions. The experimental sample of the facial transplant is an essential and mandatory stage in preparing the clinical application of the face transplant. Our study confirms the good tolerance of the hemiface transplant against the major hystocompatibility complex granted by the immunosuppression with A Cyclosporine in rodents.










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1 - 12 - 2014
16 - 8 - 2014


  • “Carol Davila” University of Medicine and Pharmacy of Bucharest, Bucharest, Romania
  • “Gr.Alexandrescu” Children Hospital of Bucharest, Bucharest, Romania
  • “Floreasca” Emergency Clinical Hospital of Bucharest, Bucharest, Romania


  • [1] Sat Sharma, Helmut Unruh, History of Adult Transplantation. E-medicine, Jun 1, 2006
  • [2] Conolly B.W., Benanzio M. Cosmas and Damian Revisited, Lanzetta M. Dubernard J.M., Petruzzo P. Hand Transplantation, Springer-Verlag Italia 2007, 3–10 http://dx.doi.org/10.1007/978-88-470-0374-3_1[Crossref]
  • [3] M. Siemionow, Y. Kulahci, In Preparation for Facial Transplantation, Eisenmann-Klein M., Neuhann-Lorenz C.-Innovations in Plastic and Aesthetic Surgery, Springer-Verlag Berlin Heidelberg 2008, 150–159 http://dx.doi.org/10.1007/978-3-540-46326-9_19[Crossref]
  • [4] Ulusal BG, Ulusal AE, Hung LM et al (2006) The effect of A2A adenosine receptor agonist on composite tissue allotransplant survival: an in vivo preliminary study. J Surg Res (Am) 131(2):261–266 http://dx.doi.org/10.1016/j.jss.2005.12.016[Crossref]
  • [5] Gift of a Lifetime, web documentary. www.OrganTransplants.org, 2004
  • [6] Baar HS (1963) From Ehrlich-Pirquet to Medawar and Burnet; A revolution in immunology. Journal of the Main Medical Association 54:209–214
  • [7] Murray JE, Merrill JP, Dammin GJ et al (1962) Kydney transplantation in modifed recipients. Ann Surg 156:337–355 http://dx.doi.org/10.1097/00000658-196209000-00002[Crossref]
  • [8] Borel J (1976) Comparative study of in vitro and in vivo drug effects on cell-mediated cytotoxicity. Immunology 31:631–641
  • [9] Martin Molitor, Takako Kanatani, Marco Lanzetta, Hind-Limb Transplantation in the Rat: Surgical Technique, Anaesthesia and Early Postoperative Management-Hand Transplantation, Springer-Verlag Italia 2007, 3–10
  • [10] Dubernard JM, Owen ER, Herzberg G et al (1999) Human hand allograft: report on first 6 months. Lancet 353:1315–1320 http://dx.doi.org/10.1016/S0140-6736(99)02062-0[Crossref]
  • [11] Lascăr I, Zamfirescu D Microchirurgia Experimentală, Paralela 45 Romania 2000,6–10,29–43
  • [12] Demir Y1, Ozmen S, Klimczak A, Mukherjee AL, Siemionow M, Tolerance induction in composite facial allograft transplantation in the rat model..Plast Reconstr Surg. 2004 Dec;114(7):1790–801 http://dx.doi.org/10.1097/01.PRS.0000142414.92308.AB[Crossref]
  • [13] Yazici, I., Unal, S., Siemionow, M. Composite hemiface/ calvaria transplantation model in rats.Plast Reconstr Surg, 118: 1321–1327, 2006 http://dx.doi.org/10.1097/01.prs.0000239452.31605.b3[Crossref]

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