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2014 | 9 | 6 | 802-806

Article title

Fetal growth promoting effect of hydroxyethylrutoside in pregnant women


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Physical description


1 - 12 - 2014
16 - 8 - 2014


  • Foundation for the Community Control of Hereditary Diseases, Budapest, Hungary
  • Foundation for the Community Control of Hereditary Diseases, Budapest, Hungary
  • Second Department of Obstetrics and Gynecology, Semmelweis University, School of Medicine, Budapest, Hungary


  • [1] Czeizel AE, Toth M: Birth weight, gestational age and medications during pregnancy. Int J Gynaecol Obstet 1998;60(3): 245–249 http://dx.doi.org/10.1016/S0020-7292(97)00273-7[Crossref]
  • [2] Galati G, Sabzevari O, Wilson JX, O’Brien PJ: Prooxidant activity and cellular effects of the phenoxyl radicals of dietary flavonoids and other polyphenolics. Toxicology 2002;177(1): 91–104 http://dx.doi.org/10.1016/S0300-483X(02)00198-1[Crossref]
  • [3] Jacobs H, van der Vijgh WJ, Koek GH, Draaisma GJ, Moalin M, van Strijdonck GP, et al.: Characterization of the glutathione conjugate of the semisynthetic flavonoid monoHER. Free Radic Biol Med 2009;46(12): 1567–1573 http://dx.doi.org/10.1016/j.freeradbiomed.2009.02.031[WoS][Crossref]
  • [4] Rusznyak S, Szent-Györgyi A: Vitamin P: Flavonals as vitamins. Nature 1936;138: 27 http://dx.doi.org/10.1038/138027a0[Crossref]
  • [5] Kienzler JL, Sallin D, Schifflers MH, Ghika A: Pharmacokinetics of mono-3′- and mono-4′- 0-(beta-hydroxyethyl)-rutoside derivatives, after single doses of Venoruton powder in healthy volunteers. Eur J Clin Pharmacol 2002;58(6): 395–402 http://dx.doi.org/10.1007/s00228-002-0472-3
  • [6] Wadworth AN, Faulds D: Hydroxyethylrutosides. A review of its pharmacology, and therapeutic efficacy in venous insufficiency and related disorders. Drugs 1992;44(6): 1013–1032 http://dx.doi.org/10.2165/00003495-199244060-00009[Crossref]
  • [7] Petruzzellis V, Troccoli T, Candiani C, Guarisco R, Lospalluti M, Belcaro G, et al.: Oxerutins (Venoruton): efficacy in chronic venous insufficiency - a double-blind, randomized, controlled study. Angiology 2002;53(3): 257–263 http://dx.doi.org/10.1177/000331970205300302[Crossref]
  • [8] Banhidy F, Acs N, Puho EH, Czeizel AE: Varicose veins of lower extremities in pregnant women and birth outcomes. Cent Eur J Public Health 2010;18(3): 161–168 [PubMed]
  • [9] Bánhidy F, Ács N, Puhó HE, AE. C,: Possible association of materanal hemorrhoid with congenital abnormalities in their children: a populationbased case-control study. Balkan J Med Genet 2010;2010; 13: 23–33
  • [10] Bergstein NA: Clinical study on the efficacy of O-(beta-hydroxyethyl)rutoside (HR) in varicosis of pregnancy. J Int Med Res 1975;3(3): 189–193
  • [11] Wijayanegara H, Mose JC, Achmad L, Sobarna R, Permadi W: A clinical trial of hydroxyethylrutosides in the treatment of haemorrhoids of pregnancy. J Int Med Res 1992;20(1): 54–60 [PubMed]
  • [12] Young GL, Jewell D: Interventions for varicosities and leg oedema in pregnancy. Cochrane Database Syst Rev 2000(2): CD001066 [WoS]
  • [13] Quijano CE, Abalos E: Conservative management of symptomatic and/or complicated haemorrhoids in pregnancy and the puerperium. Cochrane Database Syst Rev 2005(3): CD004077
  • [14] Bamigboye AA, Smyth R: Interventions for varicose veins and leg oedema in pregnancy. Cochrane Database Syst Rev 2007(1): CD001066 [WoS]
  • [15] Czeizel AE, Rockenbauer M, Siffel C, Varga E: Description and mission evaluation of the Hungarian case-control surveillance of congenital abnormalities, 1980–1996. Teratology 2001;63(5): 176–185 http://dx.doi.org/10.1002/tera.1032[Crossref]
  • [16] Czeizel AE: First 25 years of the Hungarian congenital abnormality registry. Teratology 1997;55(5): 299–305 http://dx.doi.org/10.1002/(SICI)1096-9926(199705)55:5<299::AID-TERA1>3.0.CO;2-V[Crossref]
  • [17] Czeizel AE, Petik D, Vargha P: Validation studies of drug exposures in pregnant women. Pharmacoepidemiol Drug Saf 2003;12(5): 409–416 http://dx.doi.org/10.1002/pds.766[Crossref]
  • [18] Czeizel AE, Vargha P: Periconceptional folic acid/multivitamin supplementation and twin pregnancy. Am J Obstet Gynecol 2004;191(3): 790–794 http://dx.doi.org/10.1016/j.ajog.2004.02.018[Crossref]
  • [19] Borvendég J. Gyógyszer compendium. (Hungarian),. Budapest: Havas MediMedia Információs KFT,. 2000
  • [20] Puho E, Metneki J, Czeizel AE: Maternal employment status and isolated orofacial clefts in Hungary. Cent Eur J Public Health 2005;13(3): 144–148 http://dx.doi.org/10.1007/s10389-005-0101-6[Crossref]
  • [21] Czeizel AE, Puho EH, Langmar Z, Acs N, Banhidy F: Possible association of folic acid supplementation during pregnancy with reduction of preterm birth: a population-based study. Eur J Obstet Gynecol Reprod Biol 2010;148(2): 135–140 http://dx.doi.org/10.1016/j.ejogrb.2009.10.016[Crossref]
  • [22] Vogt G, Puho E, Czeizel AE: A population-based case-control study of isolated ocular coloboma. Ophthalmic Epidemiol 2005;12(3): 191–197 http://dx.doi.org/10.1080/09286580590969699[Crossref]
  • [23] Paput L, Banhidy F, Czeizel AE: Association of drug treatments in pregnant women with the risk of external ear congenital abnormalities in their offspring: a population-based case-control study. Congenit Anom (Kyoto) 2011;51(3): 126–137 http://dx.doi.org/10.1111/j.1741-4520.2011.00319.x[Crossref]
  • [24] Rockenbauer M, Olsen J, Czeizel AE, Pedersen L, Sorensen HT: Recall bias in a case-control surveillance system on the use of medicine during pregnancy. Epidemiology 2001;12(4): 461–466 http://dx.doi.org/10.1097/00001648-200107000-00017[Crossref]
  • [25] Czeizel AE, Petik D, Puho E: Smoking and alcohol drinking during pregnancy. The reliability of retrospective maternal self-reported information. Cent Eur J Public Health 2004;12(4): 179–183

Document Type

Publication order reference


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