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2014 | 9 | 6 | 754-761

Article title

Spinal hyperbaric prilocaine vs. mepivacaine in perianal outpatient surgery


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1 - 12 - 2014
16 - 8 - 2014


  • Department of Anaesthesiology and Surgical Intensive Care Medicine, University Medical Centre Mannheim, 68167, Mannheim, Germany
  • Department of Anaesthesiology and Surgical Intensive Care Medicine, University Medical Centre Mannheim, 68167, Mannheim, Germany
  • Centre of Colo-proctology, 68165, Mannheim, Germany
  • Department of Medical Statistics, University Medical Centre Mannheim, 68167, Mannheim, Germany
  • Department of Anaesthesia, Intensive Care and Pain Therapy, University of Parma, 43100, Parma, Italy
  • Department of Anaesthesiology and Surgical Intensive Care Medicine, University Medical Centre Mannheim, 68167, Mannheim, Germany
  • Department of Anaesthesiology and Surgical Intensive Care Medicine, University Medical Centre Mannheim, 68167, Mannheim, Germany


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  • [2] Kopp, SL, Horlocker, TT. Regional anaesthesia in day-stay and short-stay surgery. Anaesthesia 2010;65Suppl 1:84–96 http://dx.doi.org/10.1111/j.1365-2044.2009.06204.x[Crossref]
  • [3] Zaric, D, Pace, NL. Transient neurologic symptoms (TNS) following spinal anaesthesia with lidocaine versus other local anaesthetics. Cochrane Database Syst Rev 2009;CD003006 [WoS]
  • [4] Freedman, JM, Li, DK, Drasner, K, Jaskela, MC, Larsen, B, Wi, S. Transient neurologic symptoms after spinal anesthesia: an epidemiologic study of 1,863 patients. Anesthesiology 1998;89:633–641 http://dx.doi.org/10.1097/00000542-199809000-00012[Crossref]
  • [5] Eberhart, LH, Morin, AM, Kranke, P, Geldner, G, Wulf, H. Transiente neurologische Symptome nach Spinalanästhesie. Eine quantitative systematische Übersicht (Metaanalyse) randomisierter kontrollierter Studien. Anaesthesist 2002;51:539–546 http://dx.doi.org/10.1007/s00101-002-0345-2[Crossref]
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  • [7] Pollock, JE, Liu, SS, Neal, JM, Stephenson, CA. Dilution of spinal lidocaine does not alter the incidence of transient neurologic symptoms. Anesthesiology 1999;90:445–450 http://dx.doi.org/10.1097/00000542-199902000-00019[Crossref]
  • [8] Hampl, KF, Heinzmann-Wiedmer, S, Luginbuehl, I, Harms, C, Seeberger, M, Schneider, MC, Drasner, K. Transient neurologic symptoms after spinal anesthesia: a lower incidence with prilocaine and bupivacaine than with lidocaine. Anesthesiology 1998;88:629–633 http://dx.doi.org/10.1097/00000542-199803000-00012[Crossref]
  • [9] Schmittner, MD, Schreiber, H, Janke, A, Weiss, C, Blunk, J, Bussen, DG, Luecke, T. Randomized clinical trial of perianal surgery performed under spinal saddle block versus total intravenous anaesthesia. Br J Surg 2010;97:12–20 http://dx.doi.org/10.1002/bjs.6792[Crossref]
  • [10] Li, S, Coloma, M, White, PF, Watcha, MF, Chiu, JW, Li, H, Huber, PJ, Jr. Comparison of the costs and recovery profiles of three anesthetic techniques for ambulatory anorectal surgery. Anesthesiology 2000;93:1225–1230 http://dx.doi.org/10.1097/00000542-200011000-00015[Crossref]
  • [11] Endrich B, FK, Schleppers A. Deutsche Gesellschaft fu?r Anaesthesiologie und Intensivmedizin/Berufsverband Deutscher Anaesthesisten Datenanforderungen auf dem Personalsektor zur Abbildung von Prozessen im OP und zur Kalkulation der DRGs. Anästhesiol Intensivmed 2002;457–461
  • [12] Kazak, Z, Ekmekci, P, Kazbek, K. Hyperbaric levobupivacaine in anal surgery: Spinal perianal and spinal saddle blocks. Anaesthesist 2010;59:709–713 http://dx.doi.org/10.1007/s00101-010-1755-1[Crossref]
  • [13] Wassef, MR, Michaels, EI, Rangel, JM, Tsyrlin, AT. Spinal perianal block: a prospective, randomized, double-blind comparison with spinal saddle block. Anesth Analg 2007 Jun;104:1594–1596 http://dx.doi.org/10.1213/01.ane.0000261510.37489.00[Crossref]
  • [14] Chernik, DA, Gillings, D, Laine, H, Hendler, J, Silver, JM, Davidson, AB, Schwam, EM, Siegel, JL. Validity and reliability of the Observer’s Assessment of Alertness/Sedation Scale: study with intravenous midazolam. J Clin Psychopharmacol 1990;10:244–251 http://dx.doi.org/10.1097/00004714-199008000-00003[Crossref]
  • [15] Aldrete, JA. Modifications to the postanesthesia score for use in ambulatory surgery. J Perianesth Nurs 1998;13:148–155 http://dx.doi.org/10.1016/S1089-9472(98)80044-0[Crossref]
  • [16] Schneider, M, Ettlin, T, Kaufmann, M, Schumacher, P, Urwyler, A, Hampl, K, von Hochstetter, A. Transient neurologic toxicity after hyperbaric subarachnoid anesthesia with 5% lidocaine. Anesth Analg 1993;76:1154–1157 http://dx.doi.org/10.1213/00000539-199305000-00044[Crossref]
  • [17] Gebhardt, V, Herold, A, Weiss, C, Samakas, A, Schmittner, MD. Dosage finding for low-dose spinal anaesthesia using hyperbaric prilocaine in patients undergoing perianal outpatient surgery. Acta Anaesthesiol Scand 2013;57:249–256 http://dx.doi.org/10.1111/aas.12031[WoS][Crossref]
  • [18] Schmittner, MD, Janke, A, Weiss, C, Beck, GC, Bussen, DG. Practicability and patients’ subjective experiences of low-dose spinal anaesthesia using hyperbaric bupivacaine for transanal surgery. Int J Colorectal Dis 2009;24:827–836 http://dx.doi.org/10.1007/s00384-009-0681-7[WoS][Crossref]
  • [19] Carron, M, Freo, U, Veronese, S, Innocente, F, Ori, C. Spinal block with 1.5 mg hyperbaric bupivacaine: not successful for everyone. Anesth Analg 2007;105:1515–1516; author reply 6 http://dx.doi.org/10.1213/01.ane.0000286079.45616.8c[WoS][Crossref]
  • [20] Fuzier, R, Bataille, B, Fuzier, V, Richez, A, Maguès, J, Choquet, O, Montastruc, J, Lapeyre-Mestre, M. Spinal anesthesia failure after local anesthetic injection into cerebrospinal fluid: a multicenter prospective analysis of its incidence and related risk factors in 1214 patients. Reg Anesth Pain Med 2011;36:322–326 http://dx.doi.org/10.1097/AAP.0b013e318217a68e[WoS]
  • [21] Camponovo, C, Fanelli, A, Ghisi, D, Cristina, D, Fanelli, G. A prospective, double-blinded, randomized, clinical trial comparing the efficacy of 40 mg and 60 mg hyperbaric 2% prilocaine versus 60 mg plain 2% prilocaine for intrathecal anesthesia in ambulatory surgery. Anesth Analg 2010;111:568–572 http://dx.doi.org/10.1213/ANE.0b013e3181e30bb8[WoS][Crossref]
  • [22] Pavlin, DJ, Pavlin, EG, Gunn, HC, Taraday, JK, Koerschgen, ME. Voiding in patients managed with or without ultrasound monitoring of bladder volume after outpatient surgery. Anesth Analg 1999;89:90–97
  • [23] O’Donnell, D, Manickam, B, Perlas, A, Karkhanis, R, Chan, VW, Syed, K, Brull, R. Spinal mepivacaine with fentanyl for outpatient knee arthroscopy surgery: a randomized controlled trial. Can J Anaesth 2010;57:32–38 http://dx.doi.org/10.1007/s12630-009-9207-6[WoS][Crossref]
  • [24] Kreutziger, J, Frankenberger, B, Luger, TJ, Richard, S, Zbinden, S. Urinary retention after spinal anaesthesia with hyperbaric prilocaine 2% in an ambulatory setting. Br J Anaesth 2010;104:582–586 http://dx.doi.org/10.1093/bja/aeq054[Crossref][WoS]
  • [25] Hendriks, MP, de Weert, CJ, Snoeck, MM, Hu, HP, Pluim, MA, Gielen, MJ. Plain articaine or prilocaine for spinal anaesthesia in day-case knee arthroscopy: a double-blind randomized trial. Br J Anaesth 2009;102:259–263 http://dx.doi.org/10.1093/bja/aen357[Crossref][WoS]
  • [26] Greene, NM. Distribution of local anesthetic solutions within the subarachnoid space. Anesth Analg 1985;64:715–730 http://dx.doi.org/10.1213/00000539-198507000-00012[Crossref]
  • [27] Imbelloni, LE, Gouveia, MA, Cordeiro, JA. Low dose of lidocaine: comparison of 15 with 20 mg/ml with dextrose for spinal anesthesia in lithotomy position and ambulatory surgery. Acta Anaesthesiol Scand 2008;52:856–861 http://dx.doi.org/10.1111/j.1399-6576.2007.01511.x[WoS][Crossref]
  • [28] Dullenkopf, A, Borgeat, A. [Local anesthetics. Differences and similarities in the “-cains”]. Anaesthesist 2003;52:329–340 http://dx.doi.org/10.1007/s00101-003-0463-5[Crossref]

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