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Journal

2014 | 9 | 5 | 619-624

Article title

A case of myositis with immunological background associated with statin use

Content

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Languages of publication

EN

Abstracts

EN
Statins might cause and/or aggravate the immune-mediated myositis in patients on long-term, stable treatment. We provide a case of polymyositis with an immunological background and gastrointestinal and urinary manifestations in patient on long-term, stable atorvastatin treatment for the past six years. The diagnose of polymyositis was established based on clinical symptoms and signs, electromyography and laboratory test results (elevated aspartate aminotransferase 279 U/L, reference range 0–40 U/L; alanine aminotransferase 198 U/L, 0–33 U/L; lactate dehydrogenase 2200 U/L, 103-227 U/L; creatine kinase 7820 U/L, 15–84 U/L; and positive antinuclear antibodies test, titer of 1:160, with suspect antisynthetase antibodies). Polymyositis was probably related to atorvastatin treatment (Naranjo score, 5). Other probable causes of the myositis were rejected. Coricosteroid therapy, methotrexate and supplementation with vitamin D did not improve the condition. The patient remained bedridden and died two months after the hospital discharge due to the acute myocardial infarction.

Keywords

Publisher

Journal

Year

Volume

9

Issue

5

Pages

619-624

Physical description

Dates

published
1 - 10 - 2014
online
31 - 7 - 2014

Contributors

  • Department of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia
  • Institute of Rheumatology, Belgrade, Serbia
author
  • Faculty of Medicine, University of Belgrade, Institute of Rheumatology, Belgrade, Serbia
  • Institute of Rheumatology, Belgrade, Serbia
  • Department of Pharmacotherapy, Faculty of Pharmacy, University of Montenegro, Podgorica, Montenegro
  • Department of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia

References

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Document Type

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.-psjd-doi-10_2478_s11536-013-0313-z
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