Orbital Rhabdomyosarcoma with a good life prognosis after surgical treatment in a 14-year-old patient

• Authors: Cristina Nicula , Dorin Nicula , Mihai Blidaru , Adrian Ghiţuică , Stefania Neamtu , Aniela Saplonţai-Pop
• Languages of publication: EN

Abstracts

EN

The orbital rhabdomyosarcoma is one of the most frequent malignant orbital tumours in children. At this age, the common histological types are the embryonal and alveolar type. The onset is mainly under the age of 16. Without a recent and correct treatment it can give metastasis in lung and bone. The hereby paper presents one clinical case of a teenager presented at the ophthalmological consultation for a small tumor located in the superomedial part of the orbit. Computed tomography (CT) and magnetic resonance imaging (MRI) supported the diagnosis revealing the location and extension of the tumor. During the surgery, we discovered two small tumors and the histological examination revealed an embryonal type of orbital rhabdomyosarcoma. After the surgery, the patient followed an oncological treatment consisting of chemotherapy and local radiotherapy. The prognosis for life was favorable, linked with the recent diagnosis and treatment, the histological type and the good response at the oncological treatment.

Keywords

EN

Orbital rhabdomyosarcoma; Local radiotherapy; Chemotherapy

• Publisher: De Gruyter Open
• Journal: Open Medicine
• Year: 2014
• Volume: 9
• Issue: 3
• Pages: 394-399

Dates

published

1 - 6 - 2014

online

8 - 7 - 2014

Contributors

author

Cristina Nicula

• Department of Ophthalmology, “Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, RO

author

Dorin Nicula

• Optilens Clinic, Cluj-Napoca, RO

author

Mihai Blidaru

• Department of Pathophysiology, “Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, RO

author

Adrian Ghiţuică

• Department of Pathology, Military Hospital, Cluj-Napoca, RO

author

Stefania Neamtu

• Department of Pediatric Oncology, “Ion Chiricută” Oncological Institute, Cluj-Napoca, RO

author

Aniela Saplonţai-Pop

• Faculty of General Medicine, „Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, RO

References

• [1] Rootman J, Neoplasia, Diseases of the orbit: a multidisciplinary approach, Lippincott Williams and Wilkins, Philadelphia, 2003, 54, 262–268
• [2] Jurdy L, Johanus HM, Pieters B, Mourits M, Kloos R, Strackee S, Saeed P. Orbital rhabdomyosarcomas: A review, Saudi J Ophthalmol. 2013, 27(3), 167–175. doi: 10.1016/j.sjopt.2013.06.004 http://dx.doi.org/10.1016/j.sjopt.2013.06.004[Crossref]
• [3] Shields JA, Shields CL, Rhabdomyosarcoma: review for the ophthalmologist, Surv Ophthalmol, 2003, 48, 39–57 http://dx.doi.org/10.1016/S0039-6257(02)00415-0[Crossref]
• [4] Turner JH, Richmon JD, Head and neck rhabdomyosarcoma: a critical analysis of populationbased incidence and survival data, Otolaryngol Head Neck Surg, 2011, 145, 967–973 http://dx.doi.org/10.1177/0194599811417063[Crossref][WoS]
• [5] Conneely MF, Mafee MF, Orbital rhabdomyosarcoma and simulating lesions, Neuroimaging Clin N Am, 2005, 15, 121–136 http://dx.doi.org/10.1016/j.nic.2005.02.006[Crossref]
• [6] Koopman JH, van der Heiden-van der Loo M, van Dijk MR, Bijlsma WR, Incidence of primary malignant orbital tumours in The Netherlands Eye (Lond), 2011, 25, 461–465 [PubMed]
• [7] Terezakis SA, Wharam MD, Radiotherapy for rhabdomyosarcoma: indications and outcome, Clin Oncol (R Coll Radiol), 2013, 25, 27–35 http://dx.doi.org/10.1016/j.clon.2012.07.009[Crossref][WoS]
• [8] Sohaib SA, Moseley I, Wright JE, Orbital rhabdomyosarcoma-the radiological characteristics, Clin Radiol, 1998, 53, 357–362 http://dx.doi.org/10.1016/S0009-9260(98)80009-3[Crossref]
• [9] Neudorfer M, Leibovitch I, Stolovitch C, Dray JP, Hermush V, Nagar H et al. Intraorbital and periorbital tumors in children-value of ultrasound and color Doppler imaging in the differential diagnosis, Am J Ophthalmol, 2004, 137, 1065–1072 http://dx.doi.org/10.1016/j.ajo.2004.01.050[Crossref]
• [10] Boparai MS, Dash RG, Clinical, ultrasonographic and CT evaluation of orbital rhabdomyosarcomas with management, Indian J Ophthalmol, 1991, 39, 129–131
• [11] Staibano S, Franco R, Tranfa F, Mezza E, Lo Muzio L, Strianese D et al. Orbital rhabdomyosarcoma: relationship between DNA ploidy, p53, bcl-2, MDR-1 and Ki67 (MIB1) expression and clinical behavior, Anticancer Res, 2004, 24, 249–257
• [12] Viswanathan S, George S, Ramadwar M, Shet T, Arora B, Laskar S et al. Extraconal orbital tumors in children - a spectrum, Virchows Arch, 2009, 454, 703–713 http://dx.doi.org/10.1007/s00428-009-0775-1[WoS][Crossref]
• [13] Kelleher FC, Viterbo A. Histologic and genetic advances in refining the diagnosis of “undifferentiated pleomorphic sarcoma, Cancers (Basel). 2013, 22,5(1):218–233. doi: 10.3390/cancers5010218 http://dx.doi.org/10.3390/cancers5010218[Crossref]
• [14] Goldblum JR. An approach to pleomorphic sarcomas: can we subclassify, and does it matter?, Mod Pathol., 2014, 27,suppl 1:S39–S46. doi: 10.1038/ modpathol.2013.174 http://dx.doi.org/10.1038/modpathol.2013.174[WoS][Crossref]
• [15] Kanski JJ, Clinical Ophtalmology, 4th ed., Butterworth Heinemann, Oxford, 1999, 581–582.
• [16] Kaliaperumal S, Tiroumal S, Rao V, Orbital rhabdomyosarcoma: a case series, Indian J Cancer., 2007, 44(3), 104–107 http://dx.doi.org/10.4103/0019-509X.38941[Crossref]
• [17] George JL, Marchal JC, Orbital tumors in children: clinical examination, imaging, specific progression, Neurochirurgie, 2010, 56(2–3), 244–248 http://dx.doi.org/10.1016/j.neuchi.2010.02.014[WoS][Crossref]
• [18] Forstner D, Borg M, Saxon B, Orbital rhabdomyosarcoma: multidisciplinary treatment experience, Australas Radiol., 2006, 50(1), 41–45 http://dx.doi.org/10.1111/j.1440-1673.2005.01526.x[Crossref]
• [19] Silvana G, Roberto De B, Domenico P, Giuseppina S, Ciracì L, Antonio C, Orbital cavitary rhabdomyosarcoma: a diagnostic dilemma, Orbit., 2010, 29(1), 45–47 http://dx.doi.org/10.3109/01676830903207802[Crossref]
• [20] Hosoi H, Et Al, A review of 331 rhabdomyosarcoma cases in patients treated between 1991 and 2002 in Japan, Int J Clin Oncol., 2007, 12(2), 137–145 http://dx.doi.org/10.1007/s10147-006-0638-6
• [21] Hayes-Jordan A, Andrassy R, Rhabdomyosarcoma in children, Curr Opin Pediatr., 2009, 21(3), 373–378 http://dx.doi.org/10.1097/MOP.0b013e32832b4171[Crossref][WoS]
• [22] Shome D, Honavar SG, Reddy VA, Vemuganti GK, Orbital embryonal rhabdomyosarcoma in association with neurofibromatosis type 1, Ophthal Plast Reconstr Surg., 2007, 23(2), 147–148 http://dx.doi.org/10.1097/IOP.0b013e318032af94
• [23] Sanz-Marco E, España E, Alamar A, Pérez-Rojas J, López-Prats MJ, Díaz-Llopis M. Orbital alveolar rhabdomyosarcoma masked by ethmoid sinusitis in a 25-year-old, Arch Soc Esp Oftalmol., 2012, S0365-6691(12)00538-2. doi: 10.1016/j. oftal.2012.10.012 [Crossref]
• [24] Colović N, Jurišić V, Terzić T, Jevtovic D, Colović M. Alveolar granulocytic sarcoma of the mandible in a patient with HIV, M. Onkologie, 2011, 34, 55–58. doi:10.1159/000317351 http://dx.doi.org/10.1159/000317351[WoS][Crossref]
• [25] Breneman JC, Lyden E, Pappo AS, Link MP, Anderson JR, Parham DM et al. Prognostic factors and clinical outcomes in children and adolescents with metastatic rhabdomyosarcoma - a report from the intergroup rhabdomyosarcoma study IV, J Clin. Oncol., 2003, 21, 78–84 http://dx.doi.org/10.1200/JCO.2003.06.129[Crossref]
• [26] Olivier Pascual N, Calvo JM, Abelairas Gómez JM, Orbital rhabdomyosarcoma: difficulties with European treatment protocol, Arch Soc Esp Oftalmol, 2005, 80, 331–338 http://dx.doi.org/10.4321/S0365-66912005000600006[Crossref]
• [27] Raney RB, Maurer HM, Anderson JR, Andrassy RJ, Donaldson SS, Qualman SJ et al., The Intergroup Rhabdomyosarcoma Study Group (IRSG): major lessons from the IRS-I through IRS-IV studies as background for the current IRS-V treatment protocols, Sarcoma, 2001, 5, 9–15 http://dx.doi.org/10.1080/13577140120048890[Crossref]
• [28] Wharam MD, Hanfelt JJ, Tefft MC, Johnston J, Ensign LG, Breneman J et al., Radiation therapy for rhabdomyosarcoma: local failure risk for clinical group III patients on intergroup rhabdomyosarcoma study II, Int J Radiat Oncol Biol Phys, 1997, 38, 797–804 http://dx.doi.org/10.1016/S0360-3016(97)00120-X[Crossref]
• [29] Shields CL, Shields JA, Honavar SG, Demirci H, Primary ophthalmic rhabdomyosarcoma in 33 patients, Trans Am Ophthalmol Soc, 2001, 99, 133–143
• [30] Rosenberg AR, Anderson JR, Lyden E, Rodeberg DA, Wolden SL, Kao SC, Parham DM, Arndt C, Hawkins DS. Early response as assessed by anatomic imaging does not predict failure-free survival among patients with Group III rhabdomyosarcoma: A report from the Children’s Oncology Group, Eur J Cancer, 2013, S0959-8049(13)01027-7. doi: 10.1016/j.ejca.2013.11.031 [WoS][Crossref]
• [31] Breneman J, Meza J, Donaldson SS, Raney RB, Wolden S, Michalski J et al., Local control with reduced-dose radiotherapy for low-risk rhabdomyosarcoma: a report from the children’s oncology group D9602 study, Int J Radiat Oncol Biol Phys, 2012, 83, 720–726
• [32] Tyl JW, Blank LE, Koornneef L, Brachytherapy in orbital tumors, Ophthalmology, 1997, 104, 1475–1479 http://dx.doi.org/10.1016/S0161-6420(97)30113-4[Crossref]

Identifiers

DOI

10.2478/s11536-013-0289-8