Antibiotics in severe acute pancreatitis

• Authors: Alejandro Serrablo , Luis Tejedor , Jessica Martínez
• Languages of publication: EN

Abstracts

EN

Acute pancreatitis (AP) is a local inflammatory response with systemic effects and an adverse evolution in 20% of cases. Its mortality rate is 5–10% in sterile and 15–40% in infected pancreatic necrosis. Infection is widely accepted as the main reason of death in AP. The evidence to enable a recommendation about antibiotic prophylaxis against infection of pancreatic necrosis is conflicting and difficult to interpret. Up to date, there is no evidence that supports the routine use of antibiotic prophylaxis in patients with severe AP. Treatment on demand seems to be the better option, avoiding excessive treatment and selection of bacterial. In infected acute pancreatitis, antibiotics of choice are imipenem, meronem or tigecycline in patients allergic to beta-lactams. Also fluconazole must be given in determinate clinical situations.

Keywords

EN

Acute pancreatitis; Antibiotic prophylaxis; Antibiotic treatment

• Publisher: De Gruyter Open
• Journal: Open Medicine
• Year: 2014
• Volume: 9
• Issue: 4
• Pages: 565-573

Dates

published

1 - 8 - 2014

online

19 - 7 - 2014

Contributors

author

Alejandro Serrablo

• HPB Surgical Unit, Miguel Servet University Hospital, Zaragoza, Spain

author

Luis Tejedor

• General Surgery Service, Punta Europa Hospital, Algeciras, Spain

author

Jessica Martínez

• HPB Surgical Unit, Miguel Servet University Hospital, Zaragoza, Spain

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Identifiers

DOI

10.2478/s11536-013-0281-3