Full-text resources of PSJD and other databases are now available in the new Library of Science.
Visit https://bibliotekanauki.pl


Preferences help
enabled [disable] Abstract
Number of results


2014 | 9 | 2 | 315-324

Article title

Bone mineral density, carotid artery intima-media thickness, and Klotho gene polymorphism in postmenopausal women


Title variants

Languages of publication













Physical description


1 - 4 - 2014
13 - 2 - 2014


  • Rheumatology Department, “Iuliu Hatieganu” University of Medicine and Pharmacy, 2-4 Clinicilor str, 400006, Cluj Napoca, Romania
  • Rheumatology Department, “Iuliu Hatieganu” University of Medicine and Pharmacy, 2-4 Clinicilor str, 400006, Cluj Napoca, Romania
  • Medical Genetic Department, “Iuliu Hatieganu” University of Medicine and Pharmacy, 2-4 Clinicilor str, 400006, Cluj Napoca, Romania
  • 2nd Internal Medicine Department, “Iuliu Hatieganu” University of Medicine and Pharmacy, 2-4 Clinicilor str, 400006, Cluj Napoca, Romania
  • 2nd Internal Medicine Department, “Iuliu Hatieganu” University of Medicine and Pharmacy, 2-4 Clinicilor str, 400006, Cluj Napoca, Romania


  • [1] Farhat G.N., Cauley J.A., The link between osteoporosis and cardiovascular disease, Clin. Cases Miner. Bone. Metab., 2008, 5, 19–34
  • [2] Qu X., Huang X., Jin F., Wang H., Yongqiang H., Tanq T., et al., Bone mineral density and all-cause, cardiovascular and stroke mortality: A meta-analysis of prospective cohort studies, Int. J. Cardiol., 2013, 166, 385–393 http://dx.doi.org/10.1016/j.ijcard.2011.10.114[Crossref]
  • [3] den Uyl D., Nurmohamed M.T., van Tuyl L.H., Raterman H.G., Lems W.F., (Sub)clinical cardiovascular disease is associated with increased bone loss and fracture risk; a systematic review of the association between cardiovascular disease and osteoporosis, Arthritis Res. Ther., 2011, 13, R5 http://dx.doi.org/10.1186/ar3224[WoS][Crossref]
  • [4] Sennerby U., Melhus H., Gedeborg R., Byberg L., Garmo H., Ahlbom A., et al., Cardiovascular diseases and risk of hip fracture., JAMA., 2009, 302, 1666–1673 http://dx.doi.org/10.1001/jama.2009.1463[Crossref]
  • [5] Bucay N., Sarosi I., Dunstan C.R., Morony S., Tarpley J., Capparelli C., et al., Osteoprotegerindeficient mice develop early onset osteoporosis and arterial calcification, Genes Dev., 1998, 12, 1260–1268 http://dx.doi.org/10.1101/gad.12.9.1260[Crossref]
  • [6] Elosua R., Ordovas J.M., Cupples L.A., Fox C.S., Polak J.F., Wolf P.A., et al., Association of APOE genotype with carotid atherosclerosis in men and women: the Framingham Heart Study, J. Lipid. Res., 2004, 45, 1868–1875 http://dx.doi.org/10.1194/jlr.M400114-JLR200[Crossref]
  • [7] Cauley J.A., Zmuda J.M., Yaffe K., Kuller L.H., Ferrell R.E., Wisniewski S.R., et al., Apolipoprotein E polymorphism: A new genetic marker of hip fracture risk-The Study of Osteoporotic Fractures, J. Bone Miner. Res., 1999, 14, 1175–1181 http://dx.doi.org/10.1359/jbmr.1999.14.7.1175[Crossref]
  • [8] Luo G., Ducy P., McKee M.D., Pinero G.J., Loyer E., Behringer R.R., et al., Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein, Nature, 1997, 386, 78–81 http://dx.doi.org/10.1038/386078a0[Crossref]
  • [9] Kuro-o M., Matsumura Y., Aizawa H., Kawaguchi H., Suga T., Utsugi T., et al., Mutation of the mouse Klotho gene leads to a syndrome resembling ageing, Nature, 1997, 390, 45–51 http://dx.doi.org/10.1038/36285[Crossref]
  • [10] Arking D.E., Krebsova A., Macek M. Sr., Macek M. Jr., Arking A., Mian I.S., et al., Association of human aging with a functional variant of Klotho, Proc. Natl. Acad. Sci. USA., 2002, 99, 856–861 http://dx.doi.org/10.1073/pnas.022484299[Crossref]
  • [11] Arking D.E., Atzmon G., Arking A., Barzilai N., Dietz H.C., Association between the functional variant of Klotho allele and high-density lipoprotein cholesterol, blood pressure, stroke, and longevity, Circ. Res., 2005, 96, 412–418 http://dx.doi.org/10.1161/01.RES.0000157171.04054.30[Crossref]
  • [12] Arking D.E., Becker D.M., Yanek L.R., Fallin D., Judge D.P., Moy T.F., et al., Klotho allele status and the risk of early-onset occult coronary artery disease., Am. J. Hum. Genet., 2003, 72, 1154–1161 http://dx.doi.org/10.1086/375035[Crossref]
  • [13] Majumdar V., Dindagur Nagaraja D., Christopher R., Association of the functional KL-VS variant of Klotho gene with early-onset ischemic stroke, Biochem. Biophys. Res. Commun., 2010, 403, 412–416 http://dx.doi.org/10.1016/j.bbrc.2010.11.045[WoS][Crossref]
  • [14] Nzietchueng R., El Shamieh S., Benachour H., Labat C., Herbeth B., Ndiaye N.C., et al., Klotho KL-VS genotype is involved in blood pressure regulation, Clin. Chim. Acta., 2011, 412, 1773–1777 http://dx.doi.org/10.1016/j.cca.2011.05.032[WoS][Crossref]
  • [15] Majumdar V., Christopher R., Association of exonic variants of Klotho with metabolic syndrome in Asian Indians, Clin. Chim. Acta., 2011, 412, 1116–1121 http://dx.doi.org/10.1016/j.cca.2011.02.034[Crossref][WoS]
  • [16] Zarrabeitia M.T., Hernandez J.L., Valero C., Zarrabeitia A.L., Ortiz F., Gonzales-Marcias J., Riancho J.A., Klotho gene polymorphism and male bone mass, Calcif. Tissue Int., 2007, 80, 10–14 http://dx.doi.org/10.1007/s00223-006-0233-x[Crossref][WoS]
  • [17] Lorenz M.W., Markus H.S., Bots M.L., Rosvall M., Sitzer M., Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and meta-analysis, Circulation, 2007, 115, 459–467 http://dx.doi.org/10.1161/CIRCULATIONAHA.106.628875[Crossref]
  • [18] Jorgensen L., Joakimsen O., Rosvold Berntsen G.K., Heuch I., Jacobsen B.K., Low bone mineral density is related to echogenic carotid artery plaques: a population-based study, Am. J. Epidemiol., 2004, 160, 549–556 http://dx.doi.org/10.1093/aje/kwh252[Crossref]
  • [19] Kim S.H., Kim Y.M., Cho M.A., Rhee Y., Hur K.Y., Kang E.S., et al., Echogenic carotid artery plaques are associated with vertebral fractures in postmenopausal women with low bone mass, Calcif. Tissue. Int., 2008, 82, 411–417 http://dx.doi.org/10.1007/s00223-008-9141-6[Crossref][WoS]
  • [20] Montalcini T., Emanuele V., Ceravolo R., Gorgone G., Sesti G., Perticone F., et al., Relation of low bone mineral density and carotid atherosclerosis in postmenopausal women, Am. J. Cardiol., 2004, 94, 266–269 http://dx.doi.org/10.1016/j.amjcard.2004.03.083[Crossref]
  • [21] Sumino H., Ichikawa S., Kasama S., Takahashi T., Sakamoto H., Kumakura H., et al., Relationship between carotid atherosclerosis and lumbar spine bone mineral density in postmenopausal women, Hypertens. Res., 2008, 31, 1191–1197 http://dx.doi.org/10.1291/hypres.31.1191[Crossref]
  • [22] Guidelines Committee. 2003 European Society of Hypertension-European Society of Cardiology guidelines for the management of arterial hypertension. J. Hypertens. 2003, 21, 1011–1053 http://dx.doi.org/10.1097/00004872-200306000-00001[Crossref]
  • [23] The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus: Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care, 1997, 20, 1183–1197
  • [24] Reiner Z, Catapano AL, De Backer G, Graham I, Taskinen MR, Wiklund O, et al., European Association for Cardiovascular Prevention & Rehabilitation, ESC Committee for Practice Guidelines (CPG) 2008–2010 and 2010–2012 Committees. ESC/EAS Guidelines for the management of dyslipidaemias: the Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS). Eur. Heart. J., 2011, 32, 1769–1818 http://dx.doi.org/10.1093/eurheartj/ehr158[Crossref]
  • [25] Stein J.H., Korcarz C.E., Hurst R.T., Lonn E., Kendall C.B., Mohler E.R., et al., American Society of Echocardiography Carotid Intima-Media Thickness Task Force. Use of carotid ultrasound to identify subclinical vascular disease and evaluate cardiovascular disease risk: a consensus statement from the American Society of Echocardiography Carotid Intima-Media Thickness Task Force. Endorsed by the Society for Vascular Medicine, J. Am. Soc. Echocardiogr., 2008, 21, 93–111 http://dx.doi.org/10.1016/j.echo.2007.11.011[WoS][Crossref]
  • [26] Wolf I., Laitman Y., Rubinek T., Abramovitz L., Novikov I., Beeri R., et al., Functional variant of Klotho: a breast cancer risk modifier among BRCA1 mutation carriers of Ashkenazi origin, Oncogene, 2010, 29, 26–33 http://dx.doi.org/10.1038/onc.2009.301[WoS]
  • [27] World Health Organization. Assessment of fracture risk and its application to screening for postmenopausal osteoporosis, WHO Technical Report Series 843, Geneva, WHO, 1994
  • [28] Invidia L., Salvioli S., Altilia S., Pierini M., Panourgia M., Monti D., et al., The frequency of Klotho KLVS polymorphism in a large Italian population, from young subjects to centenarians, suggests the presence of specific time windows for its effect, Biogerontol., 2010, 11, 67–73 http://dx.doi.org/10.1007/s10522-009-9229-z[Crossref]
  • [29] Riancho J.A., Valero C., Hernandez J.L., Ortiz F., Zarrabeitia A., Alonso M.A., et al., Association of the F352V variant of the Klotho gene with bone mineral density, Biogerontology, 2007, 8, 121–127 http://dx.doi.org/10.1007/s10522-006-9039-5[WoS][Crossref]
  • [30] Kawano K., Ogata N., Chiano M., Molloy H., Kleyn P., Spector T.D., et al., Klotho gene polymorphisms associated with bone density of aged postmenopausal women, J. Bone Miner. Res., 2002, 17, 1744–1751 http://dx.doi.org/10.1359/jbmr.2002.17.10.1744[Crossref]
  • [31] Ogata N., Matsumura Y., Shiraki M., Kawano K., Koshizuka Y., Hosoi T., et al., Association of Klotho gene polymorphism with bone density and spondylosis of the lumbar spine in postmenopausal women, Bone, 2002, 31, 37–42 http://dx.doi.org/10.1016/S8756-3282(02)00786-X[Crossref]
  • [32] Yamada Y., Ando F., Niino N., Shimokata H., Association of polymorphsms of the androgen receptor and Klotho genes with bone mineral density in Japanese women, J. Mol. Med. (Berl.)., 2005, 83, 50–57 http://dx.doi.org/10.1007/s00109-004-0578-4[Crossref]
  • [33] Mullin B.H., Wilson S.G., Islam F.M., Calautti M., Dick I.M., Devine A., et al., Klotho gene polymorphisms are associated with osteocalcin levels but not bone density of aged postmenopausal women. Calcif. Tissue Int., 2005, 77, 145–151 http://dx.doi.org/10.1007/s00223-004-0291-x[Crossref]
  • [34] Gueguen R., Jouanny P., Guillemin F., Kuntz C., Pourel, Siest G., Segregation analysis and variance components analysis of bonemineral density in healthy families, J. Bone Miner. Res., 1995, 10, 2017–2022 http://dx.doi.org/10.1002/jbmr.5650101223[Crossref]
  • [35] Stewart Y.L., Ralston S.H., Role of genetic factors in the pathogenesis of osteoporosis, J. Endocrinol., 2000, 166, 235–245 http://dx.doi.org/10.1677/joe.0.1660235[Crossref]
  • [36] Ralston S.H., Genetics of osteoporosis, Proc. Nutr. Soc., 2007, 66, 158–165 http://dx.doi.org/10.1017/S002966510700540X[Crossref]
  • [37] Ralston S.H., Uitterlinden A.G., Genetics of osteoporosis, Endocr. Rev., 2010, 31, 629–662 http://dx.doi.org/10.1210/er.2009-0044[WoS][Crossref]
  • [38] Voght M.T., San Valentin R., Forrest K.Y., Nevitt M.C., Cauley J.A., Bone Mineral density and aortic calcification: the Study of Osteoporotic Fractures, J. Am. Geriatr. Soc., 1997, 45, 140–145 [Crossref]
  • [39] Aoyagi K., Ross P.D., Orloff J., Davis K.W., Katagiri H., Washnich R.D., Low bone density is not associated with aortic calcification, Calcif. Tissue Int., 2001, 69, 20–24 http://dx.doi.org/10.1007/s002230020003[Crossref]
  • [40] McFarlane S.I., Muniyappa R., Shin J.J., Bahtiyar G., Sowers J.R., Osteoporosis and cardiovascular disease: brittle bones and boned arteries, is there a link?, Endocrine, 2004, 23, 1–10 http://dx.doi.org/10.1385/ENDO:23:1:01[Crossref]
  • [41] Anagnostis A., Karagiannis A., Kakafika A.I., Tziomalos K., Athyros V.G., Mikhailidis D.P., Atherosclerosis and osteoporosis: age-dependent degenerative processes or related entities?, Osteoporos. Int., 2009, 20, 197–207 http://dx.doi.org/10.1007/s00198-008-0648-5[Crossref]
  • [42] Banks L.M., Lees B., Macsweeney J.E., Stevenson J.C., Effect of degenerative spinal and aortic calcification on bone density measurements in postmenopausal women: links between osteoporosis and cardiovascular disease?, Eur. J. Clin. Invest., 1994, 24, 813–817 http://dx.doi.org/10.1111/j.1365-2362.1994.tb02024.x[Crossref]
  • [43] Uyama O., Yoshimoto Y., Yamamoto Y., Kawai A., Bone changes and carotid atherosclerosis in postmenopausal women, Stroke, 1997, 8, 1730–1732 http://dx.doi.org/10.1161/01.STR.28.9.1730[Crossref]
  • [44] Hmamouchi I., Allali F., Khazzani H., Bennani L., El Mansouri L., Ichchou L., et al., Low bone mineral density is realated to atherosclerosis in postmenopausal Marocan women, BMC Public Health, 2009, 9, 388 http://dx.doi.org/10.1186/1471-2458-9-388[WoS][Crossref]
  • [45] Shaffer J.R., Kammerer C.M., Rainwater D.L., O’Leary D.H., Bruder J.M., Bauer R.L., et al., Decreased bone mineral density is correlated with increased subclinical atherosclerosis in older, but not younger, Mexican American women and men: the San Antonio Family Osteoporosis Study, Calcif. Tissue Int., 2007, 81, 430–441 http://dx.doi.org/10.1007/s00223-007-9079-0[Crossref][WoS]
  • [46] Frye M.A., Melton L.J. 3rd, Bryant S.C., Fitzpatrick L.A., Wahner H.W., Scwartz R.S., et al., Osteoporosis and calcification of the aorta, Bone Miner., 1992, 19, 185–194 http://dx.doi.org/10.1016/0169-6009(92)90925-4[Crossref]

Document Type

Publication order reference


YADDA identifier

JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.