Letter to the editor - inconsistency on frequencies of the human apolipoprotein E Gene expression

• Authors: Ivan Sosa , Ines Strenja-Linic
• Languages of publication: EN

Abstracts

EN

In this letter, we share our concerns regarding fluctuations of homozygosity for ApoE/ɛ4 allele. It appeared that over time, expression of this gene raised the felled as reported by various researchers. Considering the diversity of phenotypic characteristics assigned to expression of ApoE/ɛ4, seems to be a potentially useful to direct practitioner on concrete figures related to the genetic propensity of many conditions, from circulatory to mental disorders.

Keywords

EN

Alzheimer’s disease; ApoE/ɛ4; Chronic traumatic encephalopathy

• Publisher: De Gruyter Open
• Journal: Open Medicine
• Year: 2014
• Volume: 9
• Issue: 2
• Pages: 313-314

Dates

published

1 - 4 - 2014

online

13 - 2 - 2014

Contributors

author

Ivan Sosa

• Department of Forensic Medicine and Criminalistics, Rijeka University School of Medicine, Rijeka, Croatia

author

Ines Strenja-Linic

• Neurosonoology Laboratory, Rijeka University Hospital, Rijeka, Croatia

References

• [1] D.T. Eisenberg, C.W. Kuzaw, M.G. Hayes. Worldwide allele frequencies of the human apolipoprotein E gene: climate, local adaptations, and evolutionary history. Am J Phys Anthropol. 143(2010) 100–111 http://dx.doi.org/10.1002/ajpa.21298[WoS][Crossref]
• [2] P. Hollingworth, D. Harold, L. Jones, M.J. Owen, J. Williams. Alzheimer’s disease genetics: current knowledge and future challenges. Int J Geriatr Psychiatry. 26 (2011):793–802 http://dx.doi.org/10.1002/gps.2628[WoS][Crossref]
• [3] A.C. McKee, R.C. Cantu, C.J. Nowinski, E.T. Hedley-Whyte, B.E. Gavett, A.E. Budson, V.E. Santini, H.S. Lee, C.A. Kubilus, R.A. Stern. Chronic traumatic encephalopathy in athletes: progressive tauopathy after repetitive head injury. J Neuropathol Exp Neurol. 68 (2009) 709–735 http://dx.doi.org/10.1097/NEN.0b013e3181a9d503[WoS][Crossref]
• [4] S. Yoshida, Y. Iwabuchi, Y Numachi, H. Saito, H. Yamazaki, H. Sakai, M. Kimura, H. Matsuoka, M Sato. Clinical features and alterations in the inferior horn sizes in lateral ventricle in Alzheimer’s patients with different ApoE genotype in Japanese population. Prog Neuropsychopharmacol Biol Psychiatry. 25 (2001) 1377–1384 http://dx.doi.org/10.1016/S0278-5846(01)00199-3[Crossref]

Identifiers

DOI

10.2478/s11536-013-0263-5