The effects of a 6-OHDA induced lesion in murine nuccleus accumbens on memory and oxidative stress status

• Authors: Radu Lefter , Alin Ciobica , Lucian Hritcu , Bogdan Stoica , Dumitru Cojocaru , Zenovia Olteanu
• Languages of publication: EN

Abstracts

EN

Nucleus accumbens (NAcc) are a collection of neurons that form the main part of the ventral striatum, which is a significant dopaminergic structure. Also, NAcc is thought to play an important role in reward, pleasure, laughter, addiction, aggression, fear, and the placebo effect. In the present work we were interested in studying the effects of a 6-OHDA induced lesion in the nucleus accumbens (NAcc), which is known as an important dopaminergic structure, on a specific behavioral task that involves both short term and long term spatial memory (the radial-8-arm-maze task), as well as on the oxidative stress markers (two antioxidant enzymes: superoxide dismutase-SOD and glutathione peroxidase-GPX and a lipid peroxidation marker: malondialdehyde-MDA, as well as the total antioxidant status-TAS) from the temporal lobe, which is considered to be the most vulnerable cortical area to oxygen levels fluctuations and hypoxia. Our results showed some significant effects of this lesion on the reference memory errors and time necessary to finish the test in the radial-8-arm-maze task. Additionally, increased oxidative stress status was demonstrated in the temporal lobe of the lesioned rats, as demonstrated by the high levels of lipid peroxidation and decreased total antioxidant status. Moreover, significant correlations are reported here between the behavioral parameters which we studied in the radial-8-arm-maze task and the aforementioned oxidative stress markers.

Keywords

EN

Nucleus accumbens; Spatial memory; adial-8-arm-maze; Oxidative stress

• Publisher: De Gruyter Open
• Journal: Open Medicine
• Year: 2013
• Volume: 8
• Issue: 4
• Pages: 443-449

Dates

published

1 - 8 - 2013

online

12 - 6 - 2013

Contributors

author

Radu Lefter

• “Alexandru Ioan Cuza” University, Bd. Carol I, nr. 11, Iasi, 700506, Romania

author

Alin Ciobica

author

Lucian Hritcu

• “Alexandru Ioan Cuza” University, Bd. Carol I, nr. 11, Iasi, 700506, Romania

author

Bogdan Stoica

• “Gr. T. Popa” University of Medicine and Pharmacy, 16 Universitatii Street, 700115, Iasi, Romania

author

Dumitru Cojocaru

• “Alexandru Ioan Cuza” University, Bd. Carol I, nr. 11, Iasi, 700506, Romania

author

Zenovia Olteanu

• “Alexandru Ioan Cuza” University, Bd. Carol I, nr. 11, Iasi, 700506, Romania

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Identifiers

DOI

10.2478/s11536-013-0165-6