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Journal

2013 | 8 | 4 | 383-391

Article title

Population pharmacokinetic of antiepileptic drugs in different populations

Content

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Languages of publication

EN

Abstracts

EN
This article reviews a population pharmacokinetics studies conducted during the past few years in Serbia. Studies have included three the most frequently used antiepileptic drugs (valproate, carbamazepine and lamotrigine) and different populations of epileptic patients: children, adults and heterogeneous population composed of both children and adults. The review compares obtained values of population pharmacokinetic models of clearance of these drugs, and factors that are significantly determined, making brief comments on the results of other authors on the same topic. Individualization of drug dosage is the basis of rational therapy, and factors of variability will always be subject of scientific research.

Publisher

Journal

Year

Volume

8

Issue

4

Pages

383-391

Physical description

Dates

published
1 - 8 - 2013
online
12 - 6 - 2013

Contributors

  • Pharmacology Department, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia
  • Pharmacology Department, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia

References

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Document Type

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.-psjd-doi-10_2478_s11536-013-0158-5
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