Effect of ginkgo extract on eye microcirculation in patients with diabetes

• Authors: Asta Spadiene , Nijole Savickiene , Nijole Jurgeviciene , Rimantas Zalinkevicius , Antanas Norkus , Rytas Ostrauskas , Andrejs Skesters , Alisa Silova , Hiliaras Rodovicius , Miglė Francaite-Daugeliene
• Languages of publication: EN

Abstracts

EN

The prevalence of Diabetes mellitus has increased around the world in the last decade. Anyone with diabetes is at risk of diabetic eye complications. The aim of the study was to compare effects of standardized Ginkgo biloba (Ginkgo biloba L.) dry extract (Ex.Gb) with the placebo on the microcirculation lesions of the eye in randomized double-blind placebo-controlled trial. 44 patients with type 2 diabetes mellitus were randomized to Ex.Gb 160 mg per day or placebo, and were followed up for nine months. Dose of Ex.Gb was increased to 240 mg in next nine months. Total Antioxidant Status (TAS) of plasma was measured using the Trolox equivalent antioxidant capacity assay. Ophthalmologic examination was performed by the biomicroscopic method. Vascular, intravascular and perivascular alterations were evaluated, and total conjunctival index was calculated. Though the values of the total conjunctival index and its constituent decreased (P<0.05) during the study in Ex.Gb group, there were no significant differences between these parameters as compared with placebo group. Evaluation of plasma TAS showed gradually increment, although insignificant and very small, in Ex.Gb group. The significance of Ex.Gb on development of the alterations of eye microcirculation, especially in elder patients needs to be explored further.

Keywords

EN

Gingko Biloba extract; Antioxidant; Diabetic retinopathy; Total conjunctival index

• Publisher: De Gruyter Open
• Journal: Open Medicine
• Year: 2013
• Volume: 8
• Issue: 6
• Pages: 736-741

Dates

published

1 - 12 - 2013

online

6 - 12 - 2013

Contributors

author

Asta Spadiene

• Department of Drug Chemistry, Faculty of Pharmacy, Lithuanian university of health sciences, A. Mickevičiaus 9, LT 44307, Kaunas, Lithuania

author

Nijole Savickiene

• Department of Pharmacognosy, Faculty of Pharmacy, Lithuanian university of health sciences, A. Mickevičiaus 9, LT 44307, Kaunas, Lithuania

author

Nijole Jurgeviciene

• Endocrinology Institute, Lithuanian university of health sciences, Eiveniu str. 2, LT-50009, Kaunas, Lithuania

author

Rimantas Zalinkevicius

• Endocrinology Institute, Lithuanian university of health sciences, Eiveniu str. 2, LT-50009, Kaunas, Lithuania

author

Antanas Norkus

• Endocrinology Institute, Lithuanian university of health sciences, Eiveniu str. 2, LT-50009, Kaunas, Lithuania

author

Rytas Ostrauskas

• Endocrinology Institute, Lithuanian university of health sciences, Eiveniu str. 2, LT-50009, Kaunas, Lithuania

author

Andrejs Skesters

• Laboratory of Biochemistry, Riga Stradins University, Dzirciema 16, LV-1007, Riga, Latvia

author

Alisa Silova

• Laboratory of Biochemistry, Riga Stradins University, Dzirciema 16, LV-1007, Riga, Latvia

author

Hiliaras Rodovicius

• Department of Drug Chemistry, Faculty of Pharmacy, Lithuanian university of health sciences, A. Mickevičiaus 9, LT 44307, Kaunas, Lithuania

author

Miglė Francaite-Daugeliene

• Endocrinological Clinic, Hospital of Lithuanian University of Health Sciences Kaunas Clinics, Eiveniu str. 2, LT-50009, Kaunas, Lithuania

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Identifiers

DOI

10.2478/s11536-012-0146-1