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2013 | 8 | 2 | 141-145

Article title

Density of nerve fibres in eutopic endometrium in women with endometriosis


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Endometriosis is the disease which usually takes a wide range of time to be diagnosed. Recently, the investigators found that endometriosis could be diagnosed using the density of nerve fibers in eutopic endometrium after taking endometrium bioptate. The aim of the article is to summarize the existing literature on density of nerve fibers in eutopic endometrium in women with and without endometriosis. In this review were involved only those studies which used the same exclusion criteria and the same technology to detect nerve fibers in eutopic endometrium. Our review confirmed the position of all studies’ results that detection of specific nerve fibers within eutopic endometrium using minimally invasive endometrial biopsy technique could be widely used in clinical practice to diagnose endometriosis with high specificity and sensitivity.










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1 - 4 - 2013
23 - 1 - 2013


  • Faculty of Medicine, Clinic of Obstetrics and Gynecology, Vilnius University, Antakalnio 57, Vilnius, Lithuania, LT-10207
  • Faculty of Medicine, Clinic of Obstetrics and Gynecology, Vilnius University, Antakalnio 57, Vilnius, Lithuania, LT-10207
  • Faculty of Medicine, Clinic of Obstetrics and Gynecology, Vilnius University, Antakalnio 57, Vilnius, Lithuania, LT-10207


  • [1] Chapron C., Fauconnier A., Dubuisson J.B., Barakat H., Vieira M., Bréart G., Deeply infiltrating endometriosis: relation between severity of dysmenorrhea and extent of the disease, Hum. Reprod., 2003, 18, 760–766 http://dx.doi.org/10.1093/humrep/deg152[Crossref]
  • [2] Tokushige N., Merkham R., Russell P., Fraser I.S., High density of small nerve fibres in the functional layer of the endometrium in women with endometriosis, Hum. Reprod., 2006, 3, 782–787
  • [3] Lebovic D.I., Mueller M.D., Taylor R.N., Immunobiology of endometriosis, Fertil. Steril., 2001, 75, 1–10 http://dx.doi.org/10.1016/S0015-0282(00)01630-7[Crossref]
  • [4] Kyama C.M., Overbergh L., Debrock S., Valckx D., Vander Perre S., Meuleman C. et al., Increased peritoneal endometrial gene expression of biologically relevant cytokines and growth factors during the menstrual phase in women with endometriosis, Fertil. Steril., 2006, 85, 1667–1675 http://dx.doi.org/10.1016/j.fertnstert.2005.11.060[Crossref]
  • [5] Tran L.V.P., Tokushige N., Berbic M., Markham R., Fraser I.S., Macrophages and nerve fibres in peritoneal endometriosis, Hum. Reprod., 2009, 4, 835–841 [WoS]
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  • [7] Brosens I., Puttemans P., Campo R., Gordts S., Brosens J., Non-invasive methods of diagnosis of endometriosis, Curr. Opin. Obstet. Gynecol., 2003, 15, 519–522 http://dx.doi.org/10.1097/00001703-200312000-00011[Crossref]
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  • [9] Al-Jefout M., Andreadis N., Tokushige N., Markham R., Fraser I., A pilot study to evaluate the relative efficacy of endometrial biopsy and full curettage in making a diagnosis of endometriosis by the detection of endometrial nerve fibres, Am. J. Obstet. Gynecol., 2007, 197, 578e1–578e4 http://dx.doi.org/10.1016/j.ajog.2007.04.032[Crossref][WoS]
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  • [11] Meibody F.A., Kashi A.M., Mirzaie A.Z., Amam M.G.B., Behbahani A.S., Zolali B., Najafi L., Diagnosis of endometrial nerve fibres in women with endometriosis, Arch. Gynecol. Obstet., 2011, 284, 1157–1162 http://dx.doi.org/10.1007/s00404-010-1806-5[Crossref][WoS]
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  • [14] Marcoux S., Maheux R., Berube S., Laparoscopic surgery in infertile women with minimal to mild endometriosis, Canadian Collaborative Group on Endometriosis. N Engl. J. Med., 1997, 337, 217–222

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