Preferences help
enabled [disable] Abstract
Number of results
2013 | 8 | 2 | 141-145
Article title

Density of nerve fibres in eutopic endometrium in women with endometriosis

Title variants
Languages of publication
Endometriosis is the disease which usually takes a wide range of time to be diagnosed. Recently, the investigators found that endometriosis could be diagnosed using the density of nerve fibers in eutopic endometrium after taking endometrium bioptate. The aim of the article is to summarize the existing literature on density of nerve fibers in eutopic endometrium in women with and without endometriosis. In this review were involved only those studies which used the same exclusion criteria and the same technology to detect nerve fibers in eutopic endometrium. Our review confirmed the position of all studies’ results that detection of specific nerve fibers within eutopic endometrium using minimally invasive endometrial biopsy technique could be widely used in clinical practice to diagnose endometriosis with high specificity and sensitivity.
Physical description
1 - 4 - 2013
23 - 1 - 2013
  • Faculty of Medicine, Clinic of Obstetrics and Gynecology, Vilnius University, Antakalnio 57, Vilnius, Lithuania, LT-10207
  • Faculty of Medicine, Clinic of Obstetrics and Gynecology, Vilnius University, Antakalnio 57, Vilnius, Lithuania, LT-10207
  • Faculty of Medicine, Clinic of Obstetrics and Gynecology, Vilnius University, Antakalnio 57, Vilnius, Lithuania, LT-10207
  • [1] Chapron C., Fauconnier A., Dubuisson J.B., Barakat H., Vieira M., Bréart G., Deeply infiltrating endometriosis: relation between severity of dysmenorrhea and extent of the disease, Hum. Reprod., 2003, 18, 760–766[Crossref]
  • [2] Tokushige N., Merkham R., Russell P., Fraser I.S., High density of small nerve fibres in the functional layer of the endometrium in women with endometriosis, Hum. Reprod., 2006, 3, 782–787
  • [3] Lebovic D.I., Mueller M.D., Taylor R.N., Immunobiology of endometriosis, Fertil. Steril., 2001, 75, 1–10[Crossref]
  • [4] Kyama C.M., Overbergh L., Debrock S., Valckx D., Vander Perre S., Meuleman C. et al., Increased peritoneal endometrial gene expression of biologically relevant cytokines and growth factors during the menstrual phase in women with endometriosis, Fertil. Steril., 2006, 85, 1667–1675[Crossref]
  • [5] Tran L.V.P., Tokushige N., Berbic M., Markham R., Fraser I.S., Macrophages and nerve fibres in peritoneal endometriosis, Hum. Reprod., 2009, 4, 835–841 [WoS]
  • [6] Ballard K., Lowton K., Wright J., What’s the dalay? A qualitative study of women’s experiences of reaching a diagnosis of endomentriosis, Fertil. Steril., 2006, 86, 1296–301[Crossref]
  • [7] Brosens I., Puttemans P., Campo R., Gordts S., Brosens J., Non-invasive methods of diagnosis of endometriosis, Curr. Opin. Obstet. Gynecol., 2003, 15, 519–522[Crossref]
  • [8] Bokor A., Kyama C.M., Vercruysse L., Fassbender A., Gevaert O., Vodolazkaia A., De Moor B., Fülöp V., D’Hooghe T., Density of small diameter sensory nerve fibres in endometrium: a semi-invasive diagnostic test for minimal to mild endometriosis, Hum. Reprod., 2009,12, 3025–3032[Crossref]
  • [9] Al-Jefout M., Andreadis N., Tokushige N., Markham R., Fraser I., A pilot study to evaluate the relative efficacy of endometrial biopsy and full curettage in making a diagnosis of endometriosis by the detection of endometrial nerve fibres, Am. J. Obstet. Gynecol., 2007, 197, 578e1–578e4[Crossref][WoS]
  • [10] Al-Jefout M., Dezarnaulds G., Cooper M., Tokushige N., Luscombe G.M., Markham R., Fraser I.S., Diagnosis of endometriosis by detection of nerve fibres in an endometrial biopsy: a double blind study, Hum. Reprod., 2009, 12, 3019–3024[Crossref]
  • [11] Meibody F.A., Kashi A.M., Mirzaie A.Z., Amam M.G.B., Behbahani A.S., Zolali B., Najafi L., Diagnosis of endometrial nerve fibres in women with endometriosis, Arch. Gynecol. Obstet., 2011, 284, 1157–1162[Crossref][WoS]
  • [12] Makari S., Svedas E., Railaite R.D., Cizauskas A., Makari J., The value of nerve fibers in diagnosing endometriosis, Lithuanian Obstet and Gynecol., 2012, 2, 125–130
  • [13] Melissa G., Medina & Dan I. Lebovic., Endometriosis-associated nerve fibers and pain, Obstet. Gynecol., 2009, 88, 968–975
  • [14] Marcoux S., Maheux R., Berube S., Laparoscopic surgery in infertile women with minimal to mild endometriosis, Canadian Collaborative Group on Endometriosis. N Engl. J. Med., 1997, 337, 217–222
Document Type
Publication order reference
YADDA identifier
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.