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Journal

2013 | 8 | 1 | 132-139

Article title

Involvement of oxidative stress in liver injury after subchronic intoxication with low doses of chlorpyrifos - study on rats

Content

Title variants

Languages of publication

EN

Abstracts

EN
Organophosphate compounds are nowadays the most frequently used pesticides. For these insecticides, the primary target is acetylcholinesterase and for this reason the main clinical effect of acute intoxication with organophosphate insecticides involves an irreversible inhibition of the activity of this enzyme. However, in the chronic or subchronic exposition oxidative stress has been reported as the main mechanism of its toxicity. The present study investigated the effect of three low doses (0.2, 2, 5 mg/kg bw) of chlorpyrifos for 14 or 28 days on serum liver enzymes and on oxidative stress parameters in the liver of rats. Chlorpyrifos treatment resulted in aminotransferases and alkaline phosphatase increase after 14 days (higher doses) and 28 days (all doses) treatment together with changes of antioxidative enzymes activities and reduced glutathione and malonyldialdehyde level in the liver. The enhancement of lipid peroxidation is temporary, reaching a peak after 14 days and decreasing after 28 days of treatment. Based on the experimental findings of this study the temporary liver injury caused by oxidative stress has been shown. The disturbances in the liver antioxidative status and increased liver membrane permeability may appear in case of doses near to the accepted human daily intake.

Publisher

Journal

Year

Volume

8

Issue

1

Pages

132-139

Physical description

Dates

published
1 - 2 - 2013
online
8 - 12 - 2012

Contributors

  • Department of Toxicology, Medical University in Bialystok, 15-222, Bialystok, 2 c Mickiewicza st., Poland

References

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Document Type

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.-psjd-doi-10_2478_s11536-012-0100-2
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